N-methyl-exo-THPO [Ligand Id: 5419] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL149914
  • BGT1/GABA transporter 2 in Mouse [ChEMBL: CHEMBL4228] [GtoPdb: 932] [UniProtKB: P31651]
  • This target only has 0 pki data point
1 CHEMBL149914_lig_chart_1 GABA transporter 2 Mouse
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
BGT1/GABA transporter 2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4228] [GtoPdb: 932] [UniProtKB: P31651]
ChEMBL Inhibition of [3H]GABA uptake at GAT2 in mouse astrocytes after 3 mins by scintillation counting analysis B 4.32 pIC50 48000 nM IC50 J. Med. Chem. (2013) 56: 2160-2164 [PMID:23398473]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]