apilimod   

GtoPdb Ligand ID: 9859

Synonyms: STA 5326 | STA-5326 | STA5326
Compound class: Synthetic organic
Comment: Apilimod was originally identified as an inhibitor of IL-12/IL-23 production [7], but the molecular mechanism behind this biological effect was undetermined. Inhibition of IL-12/IL-23 production has application for the treatment Th1-and Th17-mediated immunologic pathologies (which are driven by IL-12 and IL-23 respectively) [6-7]. Apilimod has subsequently been identified as a selective inhibitor of the type III phosphoinostol kinase, PIKfyve [1-2].
We provide structural details for the parent molecule, but some bioactivity data may relate to use of the mesylate salt form as stipulated by the compound's USAN (see PubChem CID 115273300).

PIKfyve has been reported as being required for Ebola virus (EBOV) infection of host cells [4], and indeed apilimod has anti-EBOV activity in vitro. A more broad-spectrum antiviral activity agiants Lassa virus (LASV), Marburg virus (MARV) [3]and SARS-CoV-2 [5] is supported in the literature.
2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 84.76
Molecular weight 418.21
XLogP 5.22
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
Canonical SMILES Cc1cccc(c1)C=NNc1nc(OCCc2ccccn2)nc(c1)N1CCOCC1
Isomeric SMILES Cc1cccc(c1)/C=N/Nc1nc(OCCc2ccccn2)nc(c1)N1CCOCC1
InChI InChI=1S/C23H26N6O2/c1-18-5-4-6-19(15-18)17-25-28-21-16-22(29-10-13-30-14-11-29)27-23(26-21)31-12-8-20-7-2-3-9-24-20/h2-7,9,15-17H,8,10-14H2,1H3,(H,26,27,28)/b25-17+
InChI Key HSKAZIJJKRAJAV-KOEQRZSOSA-N
Classification
Compound class Synthetic organic
IUPAC Name
N-[(3-methylphenyl)methylideneamino]-6-morpholin-4-yl-2-(2-pyridin-2-ylethoxy)pyrimidin-4-amine
International Nonproprietary Names
INN number INN
8763 apilimod
Synonyms
STA 5326 | STA-5326 | STA5326
Database Links
CAS Registry No. 541550-19-0 (source: WHO INN record)
GtoPdb PubChem SID 363894153
PubChem CID 10173277
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