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ChEMBL ligand: CHEMBL441687 (18.beta.-glycyrrhizic acid, .beta.-glycyrrhizin, E958, Glycyron, Glycyrrhetinic acid, Glycyrrhizate, Glycyrrhizic acid, Glycyrrhizic Acid, Glycyrrhizin, Glycyrrhizinate, Glycyrrhizinic acid, NSC-167409, NSC-234419, Potenlini) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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hydroxysteroid 11-beta dehydrogenase 1/11-beta-hydroxysteroid dehydrogenase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4235] [GtoPdb: 2763] [UniProtKB: P28845] | ||||||||
ChEMBL | Inhibition of human 11beta-HSD1 expressed in human HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay | B | 7.73 | pIC50 | 18.6 | nM | IC50 | J Nat Prod (2011) 74: 2571-2575 [PMID:22148241] |
ChEMBL | Inhibition of human microsomal 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 4455-4458 [PMID:19564108] |
ChEMBL | Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay | B | 8.22 | pIC50 | 6 | nM | IC50 | J Nat Prod (2012) 75: 599-604 [PMID:22360639] |
ChEMBL | Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA | B | 8 | pEC50 | 10 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 2748-2752 [PMID:22440625] |
hydroxysteroid 11-beta dehydrogenase 1/11-beta-hydroxysteroid dehydrogenase 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3910] [GtoPdb: 2763] [UniProtKB: P50172] | ||||||||
ChEMBL | Inhibition of mouse 11beta-HSD1 expressed in human HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay | B | 7.53 | pIC50 | 29.5 | nM | IC50 | J Nat Prod (2011) 74: 2571-2575 [PMID:22148241] |
ChEMBL | Inhibition of mouse liver microsome 11betaHSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay | B | 7.82 | pIC50 | 15 | nM | IC50 | Bioorg Med Chem (2009) 17: 5722-5732 [PMID:19574056] |
ChEMBL | Inhibition of mouse microsomal 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay | B | 8.1 | pIC50 | 8 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 4455-4458 [PMID:19564108] |
ChEMBL | Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay | B | 8.52 | pIC50 | 3 | nM | IC50 | J Nat Prod (2012) 75: 599-604 [PMID:22360639] |
ChEMBL | Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA | B | 8.1 | pEC50 | 8 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 2748-2752 [PMID:22440625] |
hydroxysteroid 11-beta dehydrogenase 2/11-beta-hydroxysteroid dehydrogenase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3746] [GtoPdb: 3143] [UniProtKB: P80365] | ||||||||
ChEMBL | Inhibition of human microsomal 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 4455-4458 [PMID:19564108] |
ChEMBL | Inhibition of human 11beta-HSD2 expressed in human HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay | B | 9.15 | pIC50 | 0.7 | nM | IC50 | J Nat Prod (2011) 74: 2571-2575 [PMID:22148241] |
ChEMBL | Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay | B | 9.4 | pIC50 | 0.4 | nM | IC50 | J Nat Prod (2012) 75: 599-604 [PMID:22360639] |
ChEMBL | Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA | B | 9 | pEC50 | 1 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 2748-2752 [PMID:22440625] |
Beta-glucuronidase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4814] [UniProtKB: P06760] | ||||||||
ChEMBL | Inhibition of rat liver beta-glucuronidase | B | 4.01 | pIC50 | 97210 | nM | IC50 | Eur J Med Chem (2020) 187: 111921-111921 [PMID:31835168] |
Beta-glucuronidase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3217380] [UniProtKB: P05804] | ||||||||
ChEMBL | Inhibition of Escherichia coli beta-glucuronidase | B | 4.92 | pIC50 | 12150 | nM | IC50 | Eur J Med Chem (2020) 187: 111921-111921 [PMID:31835168] |
ABCC2/Canalicular multispecific organic anion transporter 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073676] [GtoPdb: 780] [UniProtKB: Q63120] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of SN-38 uptake in bile canalicular membrane vesicles from SD rat | F | 5.72 | pKi | 1910 | nM | Ki | Drug Metabol Pharmacokin (2002) 17: 23-33 [PMID:15618649] |
ChEMBL | TP_TRANSPORTER: inhibition of DNP-SG uptake in bile canalicular membrane vesicles from SD rat | F | 6.08 | pKi | 840 | nM | Ki | Drug Metabol Pharmacokin (2002) 17: 23-33 [PMID:15618649] |
High mobility group protein B1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2311236] [UniProtKB: P09429] | ||||||||
ChEMBL | Binding affinity to recombinant HMGB1 B box region (90 to 175 residues) (unknown origin) expressed Escherichia coli after 5 mins by fluorescence-based assay | B | 4.06 | pKd | 87000 | nM | Kd | J Med Chem (2018) 61: 5093-5107 [PMID:29268019] |
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] | ||||||||
ChEMBL | Inhibition of human recombinant PTP1B | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3273-3276 [PMID:16580200] |
OATP1B1/Solute carrier organic anion transporter family member 1B1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1697668] [GtoPdb: 1220] [UniProtKB: Q9Y6L6] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of E1S uptake in Xenopus laevis oocytes | F | 4.8 | pKi | 15900 | nM | Ki | Hepatol Res (2003) 26: 343-347 [PMID:12963436] |
Solute carrier organic anion transporter family member 1B2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781861] [UniProtKB: Q9QZX8] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of E1S uptake in Xenopus laevis oocytes | F | 5.21 | pKi | 6100 | nM | Ki | Hepatol Res (2003) 26: 343-347 [PMID:12963436] |
OATP1B3/Solute carrier organic anion transporter family member 1B3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743121] [GtoPdb: 1221] [UniProtKB: Q9NPD5] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of BSP uptake in Xenopus laevis oocytes | F | 4.9 | pKi | 12500 | nM | Ki | Hepatol Res (2003) 26: 343-347 [PMID:12963436] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]