ChEMBL ligand: CHEMBL441687 (18.beta.-glycyrrhizic acid, .beta.-glycyrrhizin, E958, Glycyron, Glycyrrhetinic acid, Glycyrrhizate, Glycyrrhizic acid, Glycyrrhizic Acid, Glycyrrhizin, Glycyrrhizinate, Glycyrrhizinic acid, NSC-167409, NSC-234419, Potenlini)
hydroxysteroid 11-beta dehydrogenase 1/11-beta-hydroxysteroid dehydrogenase 1 in Human [ChEMBL: CHEMBL4235] [GtoPdb: 2763] [UniProtKB: P28845] hydroxysteroid 11-beta dehydrogenase 1/11-beta-hydroxysteroid dehydrogenase 1 in Mouse [ChEMBL: CHEMBL3910] [GtoPdb: 2763] [UniProtKB: P50172] There should be some charts here, you may need to enable JavaScript!
hydroxysteroid 11-beta dehydrogenase 2/11-beta-hydroxysteroid dehydrogenase 2 in Human [ChEMBL: CHEMBL3746] [GtoPdb: 3143] [UniProtKB: P80365] There should be some charts here, you may need to enable JavaScript!
Beta-glucuronidase in Rat [ChEMBL: CHEMBL4814] [UniProtKB: P06760] Beta-glucuronidase in Escherichia coli [ChEMBL: CHEMBL3217380] [UniProtKB: P05804] There should be some charts here, you may need to enable JavaScript!
ABCC2/Canalicular multispecific organic anion transporter 1 in Rat [ChEMBL: CHEMBL2073676] [GtoPdb: 780] [UniProtKB: Q63120] There should be some charts here, you may need to enable JavaScript!
high mobility group box 1/High mobility group protein B1 in Human [ChEMBL: CHEMBL2311236] [GtoPdb: 3279] [UniProtKB: P09429] There should be some charts here, you may need to enable JavaScript!
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] There should be some charts here, you may need to enable JavaScript!
OATP1B1/Solute carrier organic anion transporter family member 1B1 in Human [ChEMBL: CHEMBL1697668] [GtoPdb: 1220] [UniProtKB: Q9Y6L6] There should be some charts here, you may need to enable JavaScript!
Solute carrier organic anion transporter family member 1B2 in Rat [ChEMBL: CHEMBL1781861] [UniProtKB: Q9QZX8] There should be some charts here, you may need to enable JavaScript!
OATP1B3/Solute carrier organic anion transporter family member 1B3 in Human [ChEMBL: CHEMBL1743121] [GtoPdb: 1221] [UniProtKB: Q9NPD5] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
hydroxysteroid 11-beta dehydrogenase 1/11-beta-hydroxysteroid dehydrogenase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4235] [GtoPdb: 2763] [UniProtKB: P28845]
ChEMBL	Inhibition of human 11beta-HSD1 expressed in human HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay	B	7.73	pIC50	18.6	nM	IC50	J Nat Prod (2011) 74: 2571-2575 [PMID:22148241]
ChEMBL	Inhibition of human microsomal 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay	B	8	pIC50	10	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4455-4458 [PMID:19564108]
ChEMBL	Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay	B	8.22	pIC50	6	nM	IC50	J Nat Prod (2012) 75: 599-604 [PMID:22360639]
ChEMBL	Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA	B	8	pEC50	10	nM	EC50	Bioorg Med Chem Lett (2012) 22: 2748-2752 [PMID:22440625]
hydroxysteroid 11-beta dehydrogenase 1/11-beta-hydroxysteroid dehydrogenase 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3910] [GtoPdb: 2763] [UniProtKB: P50172]
ChEMBL	Inhibition of mouse 11beta-HSD1 expressed in human HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay	B	7.53	pIC50	29.5	nM	IC50	J Nat Prod (2011) 74: 2571-2575 [PMID:22148241]
ChEMBL	Inhibition of mouse liver microsome 11betaHSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay	B	7.82	pIC50	15	nM	IC50	Bioorg Med Chem (2009) 17: 5722-5732 [PMID:19574056]
ChEMBL	Inhibition of mouse microsomal 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay	B	8.1	pIC50	8	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4455-4458 [PMID:19564108]
ChEMBL	Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay	B	8.52	pIC50	3	nM	IC50	J Nat Prod (2012) 75: 599-604 [PMID:22360639]
ChEMBL	Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA	B	8.1	pEC50	8	nM	EC50	Bioorg Med Chem Lett (2012) 22: 2748-2752 [PMID:22440625]
hydroxysteroid 11-beta dehydrogenase 2/11-beta-hydroxysteroid dehydrogenase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3746] [GtoPdb: 3143] [UniProtKB: P80365]
ChEMBL	Inhibition of human microsomal 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay	B	9	pIC50	1	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4455-4458 [PMID:19564108]
ChEMBL	Inhibition of human 11beta-HSD2 expressed in human HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay	B	9.15	pIC50	0.7	nM	IC50	J Nat Prod (2011) 74: 2571-2575 [PMID:22148241]
ChEMBL	Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay	B	9.4	pIC50	0.4	nM	IC50	J Nat Prod (2012) 75: 599-604 [PMID:22360639]
ChEMBL	Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA	B	9	pEC50	1	nM	EC50	Bioorg Med Chem Lett (2012) 22: 2748-2752 [PMID:22440625]
Beta-glucuronidase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4814] [UniProtKB: P06760]
ChEMBL	Inhibition of rat liver beta-glucuronidase	B	4.01	pIC50	97210	nM	IC50	Eur J Med Chem (2020) 187: 111921-111921 [PMID:31835168]
Beta-glucuronidase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3217380] [UniProtKB: P05804]
ChEMBL	Inhibition of Escherichia coli beta-glucuronidase	B	4.92	pIC50	12150	nM	IC50	Eur J Med Chem (2020) 187: 111921-111921 [PMID:31835168]
ABCC2/Canalicular multispecific organic anion transporter 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073676] [GtoPdb: 780] [UniProtKB: Q63120]
ChEMBL	TP_TRANSPORTER: inhibition of SN-38 uptake in bile canalicular membrane vesicles from SD rat	F	5.72	pKi	1910	nM	Ki	Drug Metabol Pharmacokin (2002) 17: 23-33 [PMID:15618649]
ChEMBL	TP_TRANSPORTER: inhibition of DNP-SG uptake in bile canalicular membrane vesicles from SD rat	F	6.08	pKi	840	nM	Ki	Drug Metabol Pharmacokin (2002) 17: 23-33 [PMID:15618649]
high mobility group box 1/High mobility group protein B1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2311236] [GtoPdb: 3279] [UniProtKB: P09429]
ChEMBL	Binding affinity to recombinant HMGB1 B box region (90 to 175 residues) (unknown origin) expressed Escherichia coli after 5 mins by fluorescence-based assay	B	4.06	pKd	87000	nM	Kd	J Med Chem (2018) 61: 5093-5107 [PMID:29268019]
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031]
ChEMBL	Inhibition of human recombinant PTP1B	B	4	pIC50	>100000	nM	IC50	Bioorg Med Chem Lett (2006) 16: 3273-3276 [PMID:16580200]
OATP1B1/Solute carrier organic anion transporter family member 1B1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1697668] [GtoPdb: 1220] [UniProtKB: Q9Y6L6]
ChEMBL	TP_TRANSPORTER: inhibition of E1S uptake in Xenopus laevis oocytes	F	4.8	pKi	15900	nM	Ki	Hepatol Res (2003) 26: 343-347 [PMID:12963436]
Solute carrier organic anion transporter family member 1B2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781861] [UniProtKB: Q9QZX8]
ChEMBL	TP_TRANSPORTER: inhibition of E1S uptake in Xenopus laevis oocytes	F	5.21	pKi	6100	nM	Ki	Hepatol Res (2003) 26: 343-347 [PMID:12963436]
OATP1B3/Solute carrier organic anion transporter family member 1B3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743121] [GtoPdb: 1221] [UniProtKB: Q9NPD5]
ChEMBL	TP_TRANSPORTER: inhibition of BSP uptake in Xenopus laevis oocytes	F	4.9	pKi	12500	nM	Ki	Hepatol Res (2003) 26: 343-347 [PMID:12963436]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]