ChEMBL ligand: CHEMBL441687 (18.beta.-glycyrrhizic acid, .beta.-glycyrrhizin, E958, Glycyron, Glycyrrhetinic acid, Glycyrrhizate, Glycyrrhizic acid, Glycyrrhizic Acid, Glycyrrhizin, Glycyrrhizinate, Glycyrrhizinic acid, NSC-167409, NSC-234419, Potenlini)
hydroxysteroid 11-beta dehydrogenase 1/11-beta-hydroxysteroid dehydrogenase 1 in Human [ChEMBL: CHEMBL4235] [GtoPdb: 2763] [UniProtKB: P28845] hydroxysteroid 11-beta dehydrogenase 1/11-beta-hydroxysteroid dehydrogenase 1 in Mouse [ChEMBL: CHEMBL3910] [GtoPdb: 2763] [UniProtKB: P50172] There should be some charts here, you may need to enable JavaScript!
hydroxysteroid 11-beta dehydrogenase 2/11-beta-hydroxysteroid dehydrogenase 2 in Human [ChEMBL: CHEMBL3746] [GtoPdb: 3143] [UniProtKB: P80365] There should be some charts here, you may need to enable JavaScript!
Beta-glucuronidase in Rat [ChEMBL: CHEMBL4814] [UniProtKB: P06760] Beta-glucuronidase in Escherichia coli [ChEMBL: CHEMBL3217380] [UniProtKB: P05804] There should be some charts here, you may need to enable JavaScript!
ABCC2/Canalicular multispecific organic anion transporter 1 in Rat [ChEMBL: CHEMBL2073676] [GtoPdb: 780] [UniProtKB: Q63120] There should be some charts here, you may need to enable JavaScript!
High mobility group protein B1 in Human [ChEMBL: CHEMBL2311236] [UniProtKB: P09429] There should be some charts here, you may need to enable JavaScript!
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] There should be some charts here, you may need to enable JavaScript!
OATP1B1/Solute carrier organic anion transporter family member 1B1 in Human [ChEMBL: CHEMBL1697668] [GtoPdb: 1220] [UniProtKB: Q9Y6L6] There should be some charts here, you may need to enable JavaScript!
Solute carrier organic anion transporter family member 1B2 in Rat [ChEMBL: CHEMBL1781861] [UniProtKB: Q9QZX8] There should be some charts here, you may need to enable JavaScript!
OATP1B3/Solute carrier organic anion transporter family member 1B3 in Human [ChEMBL: CHEMBL1743121] [GtoPdb: 1221] [UniProtKB: Q9NPD5] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
hydroxysteroid 11-beta dehydrogenase 1/11-beta-hydroxysteroid dehydrogenase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4235] [GtoPdb: 2763] [UniProtKB: P28845]
ChEMBL	Inhibition of human 11beta-HSD1 expressed in human HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay	B	7.73	pIC50	18.6	nM	IC50	J Nat Prod (2011) 74: 2571-2575 [PMID:22148241]
ChEMBL	Inhibition of human microsomal 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay	B	8	pIC50	10	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4455-4458 [PMID:19564108]
ChEMBL	Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay	B	8.22	pIC50	6	nM	IC50	J Nat Prod (2012) 75: 599-604 [PMID:22360639]
ChEMBL	Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA	B	8	pEC50	10	nM	EC50	Bioorg Med Chem Lett (2012) 22: 2748-2752 [PMID:22440625]
hydroxysteroid 11-beta dehydrogenase 1/11-beta-hydroxysteroid dehydrogenase 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3910] [GtoPdb: 2763] [UniProtKB: P50172]
ChEMBL	Inhibition of mouse 11beta-HSD1 expressed in human HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay	B	7.53	pIC50	29.5	nM	IC50	J Nat Prod (2011) 74: 2571-2575 [PMID:22148241]
ChEMBL	Inhibition of mouse liver microsome 11betaHSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay	B	7.82	pIC50	15	nM	IC50	Bioorg Med Chem (2009) 17: 5722-5732 [PMID:19574056]
ChEMBL	Inhibition of mouse microsomal 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay	B	8.1	pIC50	8	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4455-4458 [PMID:19564108]
ChEMBL	Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay	B	8.52	pIC50	3	nM	IC50	J Nat Prod (2012) 75: 599-604 [PMID:22360639]
ChEMBL	Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA	B	8.1	pEC50	8	nM	EC50	Bioorg Med Chem Lett (2012) 22: 2748-2752 [PMID:22440625]
hydroxysteroid 11-beta dehydrogenase 2/11-beta-hydroxysteroid dehydrogenase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3746] [GtoPdb: 3143] [UniProtKB: P80365]
ChEMBL	Inhibition of human microsomal 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay	B	9	pIC50	1	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4455-4458 [PMID:19564108]
ChEMBL	Inhibition of human 11beta-HSD2 expressed in human HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay	B	9.15	pIC50	0.7	nM	IC50	J Nat Prod (2011) 74: 2571-2575 [PMID:22148241]
ChEMBL	Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay	B	9.4	pIC50	0.4	nM	IC50	J Nat Prod (2012) 75: 599-604 [PMID:22360639]
ChEMBL	Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA	B	9	pEC50	1	nM	EC50	Bioorg Med Chem Lett (2012) 22: 2748-2752 [PMID:22440625]
Beta-glucuronidase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4814] [UniProtKB: P06760]
ChEMBL	Inhibition of rat liver beta-glucuronidase	B	4.01	pIC50	97210	nM	IC50	Eur J Med Chem (2020) 187: 111921-111921 [PMID:31835168]
Beta-glucuronidase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3217380] [UniProtKB: P05804]
ChEMBL	Inhibition of Escherichia coli beta-glucuronidase	B	4.92	pIC50	12150	nM	IC50	Eur J Med Chem (2020) 187: 111921-111921 [PMID:31835168]
ABCC2/Canalicular multispecific organic anion transporter 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073676] [GtoPdb: 780] [UniProtKB: Q63120]
ChEMBL	TP_TRANSPORTER: inhibition of SN-38 uptake in bile canalicular membrane vesicles from SD rat	F	5.72	pKi	1910	nM	Ki	Drug Metabol Pharmacokin (2002) 17: 23-33 [PMID:15618649]
ChEMBL	TP_TRANSPORTER: inhibition of DNP-SG uptake in bile canalicular membrane vesicles from SD rat	F	6.08	pKi	840	nM	Ki	Drug Metabol Pharmacokin (2002) 17: 23-33 [PMID:15618649]
High mobility group protein B1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2311236] [UniProtKB: P09429]
ChEMBL	Binding affinity to recombinant HMGB1 B box region (90 to 175 residues) (unknown origin) expressed Escherichia coli after 5 mins by fluorescence-based assay	B	4.06	pKd	87000	nM	Kd	J Med Chem (2018) 61: 5093-5107 [PMID:29268019]
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031]
ChEMBL	Inhibition of human recombinant PTP1B	B	4	pIC50	>100000	nM	IC50	Bioorg Med Chem Lett (2006) 16: 3273-3276 [PMID:16580200]
OATP1B1/Solute carrier organic anion transporter family member 1B1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1697668] [GtoPdb: 1220] [UniProtKB: Q9Y6L6]
ChEMBL	TP_TRANSPORTER: inhibition of E1S uptake in Xenopus laevis oocytes	F	4.8	pKi	15900	nM	Ki	Hepatol Res (2003) 26: 343-347 [PMID:12963436]
Solute carrier organic anion transporter family member 1B2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781861] [UniProtKB: Q9QZX8]
ChEMBL	TP_TRANSPORTER: inhibition of E1S uptake in Xenopus laevis oocytes	F	5.21	pKi	6100	nM	Ki	Hepatol Res (2003) 26: 343-347 [PMID:12963436]
OATP1B3/Solute carrier organic anion transporter family member 1B3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743121] [GtoPdb: 1221] [UniProtKB: Q9NPD5]
ChEMBL	TP_TRANSPORTER: inhibition of BSP uptake in Xenopus laevis oocytes	F	4.9	pKi	12500	nM	Ki	Hepatol Res (2003) 26: 343-347 [PMID:12963436]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]