ABCC2 | ABCC subfamily | IUPHAR/BPS Guide to PHARMACOLOGY

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ABCC2

Target not currently curated in GtoImmuPdb

Target id: 780

Nomenclature: ABCC2

Abbreviated Name: MRP2, cMOAT

Systematic Nomenclature: ABCC2

Family: ABCC subfamily

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - ABCC2 ATP binding cassette subfamily C member 2
Mouse - - Abcc2 ATP-binding cassette
Rat - - Abcc2 ATP binding cassette subfamily C member 2
Previous and Unofficial Names
Canalicular multidrug resistance protein | CMOAT | cMRP | DJS | MRP2 | ATP-binding cassette, sub-family C (CFTR/MRP) member 2 | canalicular multispecific organic anion transporter | multidrug resistance associated protein 2 | multidrug resistance protein 2 | ATP-binding cassette, subfamily C (CFTR/MRP), member 2 | ATP-binding cassette
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Substrates and Reaction Kinetics
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
tenofovir Hs - - 2

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
PAK-104P Hs Inhibition 5.4 pKi 1
pKi 5.4 (Ki 3.7x10-6 M) [1]
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 3 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0071347 cellular response to interleukin-1 IEA
GO:0071354 cellular response to interleukin-6 IEA
GO:0071356 cellular response to tumor necrosis factor IEA

References

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1. Chen ZS, Kawabe T, Ono M, Aoki S, Sumizawa T, Furukawa T, Uchiumi T, Wada M, Kuwano M, Akiyama SI. (1999) Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter. Mol. Pharmacol., 56 (6): 1219-28. [PMID:10570049]

2. Kalyesubula R, Perazella MA. (2011) Nephrotoxicity of HAART. AIDS Res Treat, 2011: 562790. [PMID:21860787]

Contributors

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