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Target not currently curated in GtoImmuPdb
Target id: 3143
Nomenclature: hydroxysteroid 11-beta dehydrogenase 2
Abbreviated Name: 11-βHSD2
Family: 1.-.-.- Oxidoreductases
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 405 | 16q22.1 | HSD11B2 | hydroxysteroid 11-beta dehydrogenase 2 | |
Mouse | - | 386 | 8 53.04 cM | Hsd11b2 | hydroxysteroid 11-beta dehydrogenase 2 |
Database Links | |
Alphafold | P80365 (Hs), P51661 (Mm) |
ChEMBL Target | CHEMBL3746 (Hs), CHEMBL3490 (Mm) |
Ensembl Gene | ENSG00000176387 (Hs), ENSMUSG00000031891 (Mm) |
Entrez Gene | 3291 (Hs), 15484 (Mm) |
Human Protein Atlas | ENSG00000176387 (Hs) |
KEGG Gene | hsa:3291 (Hs), mmu:15484 (Mm) |
OMIM | 614232 (Hs) |
Pharos | P80365 (Hs) |
UniProtKB | P80365 (Hs), P51661 (Mm) |
Wikipedia | HSD11B2 (Hs) |
Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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View species-specific inhibitor tables |
1. Beseda I, Czollner L, Shah PS, Khunt R, Gaware R, Kosma P, Stanetty C, Del Ruiz-Ruiz MC, Amer H, Mereiter K et al.. (2010) Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases. Bioorg Med Chem, 18 (1): 433-54. [PMID:19914836]
2. Chen XQ, Shao LD, Pal M, Shen Y, Cheng X, Xu G, Peng LY, Wang K, Pan ZH, Li MM et al.. (2015) Hupehenols A-E, selective 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors from Viburnum hupehense. J Nat Prod, 78 (2): 330-4. [PMID:25590374]
1.-.-.- Oxidoreductases: hydroxysteroid 11-beta dehydrogenase 2. Last modified on 01/10/2020. Accessed on 08/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3143.