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ChEMBL ligand: CHEMBL226403 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137] | ||||||||
GtoPdb | - | - | 8.07 | pIC50 | 8.5 | nM | IC50 | J. Med. Chem. (2007) 50: 2647-54 [PMID:17480064] |
ChEMBL | Inhibition of MK2 | B | 8.07 | pIC50 | 8.5 | nM | IC50 | J. Med. Chem. (2007) 50: 2647-2654 [PMID:17480064] |
ChEMBL | Inhibition of human recombinant MK2 expressed in Escherichia coli BL21(DE3) after 60 mins | B | 8.07 | pIC50 | 8.5 | nM | IC50 | J. Med. Chem. (2008) 51: 6225-6229 [PMID:18771253] |
ChEMBL | Inhibition of MK2 pretreated for 30 mins before substrate addition measured after 2 hrs by IMAP assay | B | 7.31 | pEC50 | 49 | nM | EC50 | Bioorg. Med. Chem. Lett. (2011) 21: 3818-3822 [PMID:21565500] |
MAPK activated protein kinase 3/MAP kinase-activated protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4670] [GtoPdb: 2095] [UniProtKB: Q16644] | ||||||||
ChEMBL | Inhibition of MK3 | B | 6.68 | pIC50 | 210 | nM | IC50 | J. Med. Chem. (2007) 50: 2647-2654 [PMID:17480064] |
GtoPdb | - | - | 6.68 | pIC50 | 210 | nM | IC50 | J. Med. Chem. (2007) 50: 2647-54 [PMID:17480064] |
MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41] | ||||||||
GtoPdb | - | - | 6.09 | pIC50 | 810 | nM | IC50 | J. Med. Chem. (2007) 50: 2647-54 [PMID:17480064] |
ChEMBL | Inhibition of MAPKAPK5 (unknown origin) | B | 7 | pIC50 | 100 | nM | IC50 | J. Med. Chem. (2013) 56: 6991-7002 [PMID:23937569] |
ChEMBL | Inhibition of MK5 | B | 7.09 | pIC50 | 81 | nM | IC50 | J. Med. Chem. (2007) 50: 2647-2654 [PMID:17480064] |
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] | ||||||||
ChEMBL | Inhibition of ERK2 | B | 5.46 | pIC50 | 3440 | nM | IC50 | J. Med. Chem. (2007) 50: 2647-2654 [PMID:17480064] |
MAPK interacting serine/threonine kinase 1/MAP kinase-interacting serine/threonine-protein kinase MNK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4718] [GtoPdb: 2104] [UniProtKB: Q9BUB5] | ||||||||
ChEMBL | Inhibition of MNK1 | B | 5.24 | pIC50 | 5700 | nM | IC50 | J. Med. Chem. (2007) 50: 2647-2654 [PMID:17480064] |
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
ChEMBL | Inhibition of p38alpha | B | 4 | pIC50 | >100000 | nM | IC50 | J. Med. Chem. (2007) 50: 2647-2654 [PMID:17480064] |
ChEMBL data shown on this page come from version 27:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]