ChEMBL ligand: CHEMBL226403
MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137] There should be some charts here, you may need to enable JavaScript!
MAPK activated protein kinase 3/MAP kinase-activated protein kinase 3 in Human [ChEMBL: CHEMBL4670] [GtoPdb: 2095] [UniProtKB: Q16644] There should be some charts here, you may need to enable JavaScript!
MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] There should be some charts here, you may need to enable JavaScript!
MAPK interacting serine/threonine kinase 1/MAP kinase-interacting serine/threonine-protein kinase MNK1 in Human [ChEMBL: CHEMBL4718] [GtoPdb: 2104] [UniProtKB: Q9BUB5] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137]
GtoPdb	-	-	8.07	pIC50	8.5	nM	IC50	J Med Chem (2007) 50: 2647-54 [PMID:17480064]
ChEMBL	Inhibition of MK2	B	8.07	pIC50	8.5	nM	IC50	J Med Chem (2007) 50: 2647-2654 [PMID:17480064]
ChEMBL	Inhibition of human recombinant MK2 expressed in Escherichia coli BL21(DE3) after 60 mins	B	8.07	pIC50	8.5	nM	IC50	J Med Chem (2008) 51: 6225-6229 [PMID:18771253]
ChEMBL	Inhibition of MK2 pretreated for 30 mins before substrate addition measured after 2 hrs by IMAP assay	B	7.31	pEC50	49	nM	EC50	Bioorg Med Chem Lett (2011) 21: 3818-3822 [PMID:21565500]
MAPK activated protein kinase 3/MAP kinase-activated protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4670] [GtoPdb: 2095] [UniProtKB: Q16644]
ChEMBL	Inhibition of MK3	B	6.68	pIC50	210	nM	IC50	J Med Chem (2007) 50: 2647-2654 [PMID:17480064]
GtoPdb	-	-	6.68	pIC50	210	nM	IC50	J Med Chem (2007) 50: 2647-54 [PMID:17480064]
MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41]
GtoPdb	-	-	6.09	pIC50	810	nM	IC50	J Med Chem (2007) 50: 2647-54 [PMID:17480064]
ChEMBL	Inhibition of MAPKAPK5 (unknown origin)	B	7	pIC50	100	nM	IC50	J Med Chem (2013) 56: 6991-7002 [PMID:23937569]
ChEMBL	Inhibition of MK5	B	7.09	pIC50	81	nM	IC50	J Med Chem (2007) 50: 2647-2654 [PMID:17480064]
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
ChEMBL	Inhibition of ERK2	B	5.46	pIC50	3440	nM	IC50	J Med Chem (2007) 50: 2647-2654 [PMID:17480064]
MAPK interacting serine/threonine kinase 1/MAP kinase-interacting serine/threonine-protein kinase MNK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4718] [GtoPdb: 2104] [UniProtKB: Q9BUB5]
ChEMBL	Inhibition of MNK1	B	5.24	pIC50	5700	nM	IC50	J Med Chem (2007) 50: 2647-2654 [PMID:17480064]
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
ChEMBL	Inhibition of p38alpha	B	4	pIC50	>100000	nM	IC50	J Med Chem (2007) 50: 2647-2654 [PMID:17480064]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]