compound 16 [PMID: 17480064] [Ligand Id: 8177] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL226403
  • MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137]
There should be some charts here, you may need to enable JavaScript!
  • MAPK activated protein kinase 3/MAP kinase-activated protein kinase 3 in Human [ChEMBL: CHEMBL4670] [GtoPdb: 2095] [UniProtKB: Q16644]
There should be some charts here, you may need to enable JavaScript!
  • MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41]
There should be some charts here, you may need to enable JavaScript!
  • mitogen-activated protein kinase 1/MAP kinase ERK2 in Human [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
There should be some charts here, you may need to enable JavaScript!
  • MAPK interacting serine/threonine kinase 1/MAP kinase-interacting serine/threonine-protein kinase MNK1 in Human [ChEMBL: CHEMBL4718] [GtoPdb: 2104] [UniProtKB: Q9BUB5]
There should be some charts here, you may need to enable JavaScript!
  • mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137]
GtoPdb - - 8.07 pIC50 8.5 nM IC50 J Med Chem (2007) 50: 2647-54 [PMID:17480064]
ChEMBL Inhibition of MK2 B 8.07 pIC50 8.5 nM IC50 J Med Chem (2007) 50: 2647-2654 [PMID:17480064]
ChEMBL Inhibition of human recombinant MK2 expressed in Escherichia coli BL21(DE3) after 60 mins B 8.07 pIC50 8.5 nM IC50 J Med Chem (2008) 51: 6225-6229 [PMID:18771253]
ChEMBL Inhibition of MK2 pretreated for 30 mins before substrate addition measured after 2 hrs by IMAP assay B 7.31 pEC50 49 nM EC50 Bioorg Med Chem Lett (2011) 21: 3818-3822 [PMID:21565500]
MAPK activated protein kinase 3/MAP kinase-activated protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4670] [GtoPdb: 2095] [UniProtKB: Q16644]
ChEMBL Inhibition of MK3 B 6.68 pIC50 210 nM IC50 J Med Chem (2007) 50: 2647-2654 [PMID:17480064]
GtoPdb - - 6.68 pIC50 210 nM IC50 J Med Chem (2007) 50: 2647-54 [PMID:17480064]
MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41]
GtoPdb - - 6.09 pIC50 810 nM IC50 J Med Chem (2007) 50: 2647-54 [PMID:17480064]
ChEMBL Inhibition of MAPKAPK5 (unknown origin) B 7 pIC50 100 nM IC50 J Med Chem (2013) 56: 6991-7002 [PMID:23937569]
ChEMBL Inhibition of MK5 B 7.09 pIC50 81 nM IC50 J Med Chem (2007) 50: 2647-2654 [PMID:17480064]
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
ChEMBL Inhibition of ERK2 B 5.46 pIC50 3440 nM IC50 J Med Chem (2007) 50: 2647-2654 [PMID:17480064]
MAPK interacting serine/threonine kinase 1/MAP kinase-interacting serine/threonine-protein kinase MNK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4718] [GtoPdb: 2104] [UniProtKB: Q9BUB5]
ChEMBL Inhibition of MNK1 B 5.24 pIC50 5700 nM IC50 J Med Chem (2007) 50: 2647-2654 [PMID:17480064]
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
ChEMBL Inhibition of p38alpha B 4 pIC50 >100000 nM IC50 J Med Chem (2007) 50: 2647-2654 [PMID:17480064]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]