compound 16 [PMID: 17480064] [Ligand Id: 8177] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL226403
  • MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137]
  • This target only has 0 pki data point
  • 0
1 CHEMBL226403_lig_chart_1 MAP kinase-activated protein kinase 2 Human
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  • MAPK activated protein kinase 3/MAP kinase-activated protein kinase 3 in Human [ChEMBL: CHEMBL4670] [GtoPdb: 2095] [UniProtKB: Q16644]
  • This target only has 0 pki data point
  • 0
2 CHEMBL226403_lig_chart_2 MAP kinase-activated protein kinase 3 Human
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  • MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41]
  • This target only has 0 pki data point
  • 0
3 CHEMBL226403_lig_chart_3 MAP kinase-activated protein kinase 5 Human
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  • mitogen-activated protein kinase 1/MAP kinase ERK2 in Human [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
  • This target only has 0 pki data point
  • 0
4 CHEMBL226403_lig_chart_4 MAP kinase ERK2 Human
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  • MAPK interacting serine/threonine kinase 1/MAP kinase-interacting serine/threonine-protein kinase MNK1 in Human [ChEMBL: CHEMBL4718] [GtoPdb: 2104] [UniProtKB: Q9BUB5]
  • This target only has 0 pki data point
  • 0
5 CHEMBL226403_lig_chart_5 MAP kinase-interacting serine/threonine-protein kinase MNK1 Human
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  • mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
  • This target only has 0 pki data point
  • 0
6 CHEMBL226403_lig_chart_6 MAP kinase p38 alpha Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137]
GtoPdb - - 8.07 pIC50 8.5 nM IC50 J Med Chem (2007) 50: 2647-54 [PMID:17480064]
ChEMBL Inhibition of MK2 B 8.07 pIC50 8.5 nM IC50 J. Med. Chem. (2007) 50: 2647-2654 [PMID:17480064]
ChEMBL Inhibition of human recombinant MK2 expressed in Escherichia coli BL21(DE3) after 60 mins B 8.07 pIC50 8.5 nM IC50 J. Med. Chem. (2008) 51: 6225-6229 [PMID:18771253]
ChEMBL Inhibition of MK2 pretreated for 30 mins before substrate addition measured after 2 hrs by IMAP assay B 7.31 pEC50 49 nM EC50 Bioorg. Med. Chem. Lett. (2011) 21: 3818-3822 [PMID:21565500]
MAPK activated protein kinase 3/MAP kinase-activated protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4670] [GtoPdb: 2095] [UniProtKB: Q16644]
ChEMBL Inhibition of MK3 B 6.68 pIC50 210 nM IC50 J. Med. Chem. (2007) 50: 2647-2654 [PMID:17480064]
GtoPdb - - 6.68 pIC50 210 nM IC50 J Med Chem (2007) 50: 2647-54 [PMID:17480064]
MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41]
GtoPdb - - 6.09 pIC50 810 nM IC50 J Med Chem (2007) 50: 2647-54 [PMID:17480064]
ChEMBL Inhibition of MAPKAPK5 (unknown origin) B 7 pIC50 100 nM IC50 J. Med. Chem. (2013) 56: 6991-7002 [PMID:23937569]
ChEMBL Inhibition of MK5 B 7.09 pIC50 81 nM IC50 J. Med. Chem. (2007) 50: 2647-2654 [PMID:17480064]
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
ChEMBL Inhibition of ERK2 B 5.46 pIC50 3440 nM IC50 J. Med. Chem. (2007) 50: 2647-2654 [PMID:17480064]
MAPK interacting serine/threonine kinase 1/MAP kinase-interacting serine/threonine-protein kinase MNK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4718] [GtoPdb: 2104] [UniProtKB: Q9BUB5]
ChEMBL Inhibition of MNK1 B 5.24 pIC50 5700 nM IC50 J. Med. Chem. (2007) 50: 2647-2654 [PMID:17480064]
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
ChEMBL Inhibition of p38alpha B 4 pIC50 >100000 nM IC50 J. Med. Chem. (2007) 50: 2647-2654 [PMID:17480064]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]