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nevirapine   Click here for help

GtoPdb Ligand ID: 12676

Synonyms: BI-RG-587 | BIRG-587 | BIRG587 | NVP | Viramune®
Approved drug PDB Ligand
nevirapine is an approved drug (FDA (1996), EMA (1998))
Compound class: Synthetic organic
Comment: Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) class antiretriviral drug.

nevirapine is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 57.06
Molecular weight 266.3
XLogP 0.51
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CC1=CC=NC2=C1NC(=O)C3=CC=CN=C3N2C4CC4
Isomeric SMILES CC1=C2C(=NC=C1)N(C3=C(C=CC=N3)C(=O)N2)C4CC4
InChI InChI=1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)
InChI Key NQDJXKOVJZTUJA-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. EU EMA (1998)  |  US FDA (1996)
WHO Essential Medicine WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
IUPAC Name Click here for help
4-amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]pyrimidin-2-one
International Nonproprietary Names Click here for help
INN number INN
6815 nevirapine
Synonyms Click here for help
BI-RG-587 | BIRG-587 | BIRG587 | NVP | Viramune®
Database Links Click here for help
BindingDB Ligand 1434
ChEBI CHEBI:63613
ChEMBL Ligand CHEMBL57
DrugBank Ligand DB00238
GtoPdb PubChem SID 483123224
PubChem CID 4463
RCSB PDB Ligand NVP
Search Google for chemical match using the InChIKey NQDJXKOVJZTUJA-UHFFFAOYSA-N
Search Google for chemicals with the same backbone NQDJXKOVJZTUJA
Search PubMed clinical trials nevirapine
Search PubMed titles nevirapine
Search PubMed titles/abstracts nevirapine
UniChem Compound Search for chemical match using the InChIKey NQDJXKOVJZTUJA-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey NQDJXKOVJZTUJA-UHFFFAOYSA-N

Product suppliers

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Product supplier links are provided as a service to assist in identifying commercial suppliers of reagents that are mentioned on the IUPHAR/BPS Guide to PHARMACOLOGY database website, and do not imply their endorsement by NC-IUPHAR.

Links are provided in return for sponsorship, used to fund improvements to this database. The sponsorship account is managed and audited by the University of Edinburgh, a charitable body registered in Scotland, SC005336. If you are interested in sponsoring the database, please contact us.

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MedChemExpress
Nevirapine (links to external site)
Cat. No. HY-10570