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Synonyms: AN100226 | anti-alpha4 integrin | anti-VLA4 | Tysabri®
natalizumab is an approved drug (FDA (2004), EMA (2006))
Compound class:
Antibody
Comment: Natalizumab was the first migration-inhibitory biological drug to be approved for inflammatory diseases. It targets α4β1 integrin (VLA-4) on leukocytes to block interaction with vascular cell adhesion molecule 1 (VCAM-1) on inflamed endothelium, thus inhibiting leukocyte extravasation into sites of inflammation. It is active in peripheral tissues and the central vervous system.
Targeting cell migration-related molecules in immune conditions (and cancer) is regarded as a valid approach for the development of novel anti-inflammatory therapeutics [3]. The design and synthesis of this antibody was originally described in a 1997 publication [2]. Biosimilars: The first natalizumab biosimilar was approved by the FDA in August 2023 and by the EMA a month later. Like the originator/reference agent, Tyruko® (natalizumab-sztn; Sandoz Inc.) is indicated for relapsing forms of multiple sclerosis and moderate-severe active Crohn's disease (when conventional therapies, including TNF-α inhibitors, are inadequate or not tolerated). 
View more information in the IUPHAR Pharmacology Education Project: natalizumab |
Classification  |
|
| Compound class | Antibody |
| Approved drug? | Yes (FDA (2004), EMA (2006)) |
| Approved drug? | Yes. FDA (2004) | EMA (2006) |
| International Nonproprietary Names |
|
| INN number | INN |
| 7716 | natalizumab |
| Synonyms |
| AN100226 | anti-alpha4 integrin | anti-VLA4 | Tysabri® |
| Database Links |
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| Specialist databases | |
| IMGT/mAb-DB | 75 |
Reactome Drug
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R-ALL-9679737 |
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Reactome Reaction
|
R-HSA-9679740 |
| Other databases | |
| GtoPdb PubChem SID | 178103204 |
| PubChem SID | 178103204 |
| Search PubMed clinical trials | natalizumab |
| Search PubMed titles | natalizumab |
| Search PubMed titles/abstracts | natalizumab |
| Wikipedia | Natalizumab |
