natalizumab   Click here for help

GtoPdb Ligand ID: 6591

Synonyms: AN100226 | anti-alpha4 integrin | anti-VLA4 | Tysabri®
Approved drug Immunopharmacology Ligand
natalizumab is an approved drug (FDA (2004), EMA (2006))
Compound class: Antibody
Comment: Natalizumab was the first migration-inhibitory biological drug to be approved for inflammatory diseases.
Targeting cell migration-related molecules in immune conditions (and cancer) is regarded as a significant new focus for the development of novel anti-inflammatory therapeutics [3].
The design and synthesis of this antibody is described in [2], but the article is not open access.
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Immunopharmacology Comments
Natalizumab targets α4-containing intergrins, including the α4β1 lymphocyte homing receptor.
Immunopharmacology Disease
Disease X-Refs Comment References
Crohn's disease Disease Ontology: DOID:8778
OMIM: 266600
Orphanet: ORPHA206
Approved drug for CD.
Multiple sclerosis Disease Ontology: DOID:2377
OMIM: 126200
Orphanet: ORPHA802
Approved for the treatment of relapsing forms of multiple sclerosis.