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denileukin diftitox   Click here for help

GtoPdb Ligand ID: 7044

Synonyms: DAB389 IL2 | denileukin diftitox-cxdl | LY 335348 | Lymphir® | Ontak®
Approved drug Immunopharmacology Ligand
denileukin diftitox is an approved drug (FDA (1999))
Compound class: Peptide
Comment: Denileukin diftitox is an anti-cancer immunotherapy drug that was designed to target and eradicate malignant (IL-2 receptor-expressing) T cells. It is a recombinant protein containing peptide sequences of both interleukin-2 and diphtheria toxin [1,5]. It simultaneously directly kills IL-2R expressing tumour cells and promotes depletion of host Treg cells which enhances the immune response
Classification Click here for help
Compound class Peptide
Approved drug? Yes. US FDA (1999)
International Nonproprietary Names Click here for help
INN number INN
7680 denileukin diftitox
Synonyms Click here for help
DAB389 IL2 | denileukin diftitox-cxdl | LY 335348 | Lymphir® | Ontak®
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 704
Other databases
CAS Registry No. 173146-27-5 (source: SciFinder)
ChEMBL Ligand CHEMBL1201550
DrugBank Ligand DB00004
GtoPdb PubChem SID 178103623
Search PubMed clinical trials denileukin diftitox
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Wikipedia Denileukin_diftitox