alpha-ketothiazole analogue 36 [Ligand Id: 6549] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL273653
  • coagulation factor X/Coagulation factor X in Human [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742]
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  • coagulation factor XI/Coagulation factor XI in Human [ChEMBL: CHEMBL2820] [GtoPdb: 2360] [UniProtKB: P03951]
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  • coagulation factor II, thrombin/Thrombin in Human [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
coagulation factor X/Coagulation factor X in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742]
ChEMBL Inhibition of factor 10a B 5.72 pIC50 1900 nM IC50 J Med Chem (2006) 49: 7781-7791 [PMID:17181160]
ChEMBL Inhibition of human factor 10a B 5.72 pIC50 1900 nM IC50 Bioorg Med Chem (2008) 16: 1562-1595 [PMID:18053726]
coagulation factor XI/Coagulation factor XI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2820] [GtoPdb: 2360] [UniProtKB: P03951]
GtoPdb - - 7.5 pIC50 30 nM IC50 Bioorg Med Chem (2008) 16: 1562-95 [PMID:18053726]
ChEMBL Inhibition of factor 11a B 7.52 pIC50 30 nM IC50 J Med Chem (2006) 49: 7781-7791 [PMID:17181160]
ChEMBL Inhibition of human factor 11a B 7.52 pIC50 30 nM IC50 Bioorg Med Chem (2008) 16: 1562-1595 [PMID:18053726]
coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734]
ChEMBL Inhibition of thrombin B 5.96 pIC50 1100 nM IC50 J Med Chem (2006) 49: 7781-7791 [PMID:17181160]
ChEMBL Inhibition of human alpha-thrombin B 5.96 pIC50 1100 nM IC50 Bioorg Med Chem (2008) 16: 1562-1595 [PMID:18053726]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]