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ChEMBL ligand: CHEMBL273653 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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coagulation factor X/Coagulation factor X in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742] | ||||||||
ChEMBL | Inhibition of factor 10a | B | 5.72 | pIC50 | 1900 | nM | IC50 | J Med Chem (2006) 49: 7781-7791 [PMID:17181160] |
ChEMBL | Inhibition of human factor 10a | B | 5.72 | pIC50 | 1900 | nM | IC50 | Bioorg Med Chem (2008) 16: 1562-1595 [PMID:18053726] |
coagulation factor XI/Coagulation factor XI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2820] [GtoPdb: 2360] [UniProtKB: P03951] | ||||||||
GtoPdb | - | - | 7.5 | pIC50 | 30 | nM | IC50 | Bioorg Med Chem (2008) 16: 1562-95 [PMID:18053726] |
ChEMBL | Inhibition of factor 11a | B | 7.52 | pIC50 | 30 | nM | IC50 | J Med Chem (2006) 49: 7781-7791 [PMID:17181160] |
ChEMBL | Inhibition of human factor 11a | B | 7.52 | pIC50 | 30 | nM | IC50 | Bioorg Med Chem (2008) 16: 1562-1595 [PMID:18053726] |
coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734] | ||||||||
ChEMBL | Inhibition of thrombin | B | 5.96 | pIC50 | 1100 | nM | IC50 | J Med Chem (2006) 49: 7781-7791 [PMID:17181160] |
ChEMBL | Inhibition of human alpha-thrombin | B | 5.96 | pIC50 | 1100 | nM | IC50 | Bioorg Med Chem (2008) 16: 1562-1595 [PMID:18053726] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]