SAFit1 [Ligand Id: 11481] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3623612 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| FKBP prolyl isomerase 1A/FK506-binding protein 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1902] [GtoPdb: 2609] [UniProtKB: P62942] | ||||||||
| ChEMBL | Binding affinity to FKBP12 (unknown origin) by competitive fluorescence polarization assay | B | 7.05 | pKi | 90 | nM | Ki | J Med Chem (2015) 58: 7796-7806 [PMID:26419422] |
| FKBP prolyl isomerase 4/FK506 binding protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4050] [GtoPdb: 3176] [UniProtKB: Q02790] | ||||||||
| ChEMBL | Binding affinity to FKBP52 (unknown origin) by competitive fluorescence polarization assay | B | 4.3 | pKi | >50000 | nM | Ki | J Med Chem (2015) 58: 7796-7806 [PMID:26419422] |
| FKBP prolyl isomerase 5/Peptidyl-prolyl cis-trans isomerase FKBP5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2052031] [GtoPdb: 3175] [UniProtKB: Q13451] | ||||||||
| ChEMBL | Binding affinity to FKBP51 FK1 domain (unknown origin) assessed as dissociation constant at 25 degreeC by isothermal titration calorimetric analysis | B | 8.01 | pKd | 9.8 | nM | Kd | J Med Chem (2021) 64: 3320-3349 [PMID:33666419] |
| ChEMBL | Displacement of iFit-FL from FKBP51 (unknown origin) by fluorescence polarization assay | B | 8.4 | pKi | 4 | nM | Ki | J Med Chem (2015) 58: 7796-7806 [PMID:26419422] |
| ChEMBL | Binding affinity to FKBP51 (unknown origin) by competitive fluorescence polarization assay | B | 8.4 | pKi | 4 | nM | Ki | J Med Chem (2016) 59: 2410-2422 [PMID:26954324] |
| GtoPdb | - | - | 8.4 | pKi | 4 | nM | Ki | Nat Chem Biol (2015) 11: 33-7 [PMID:25436518] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
