danicopan [Ligand Id: 11988] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4250860 (Ach-0144471, ACH-0144471, ACH-4471, Danicopan) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| complement factor D/Complement factor D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2176771] [GtoPdb: 2842] [UniProtKB: P00746] | ||||||||
| GtoPdb | Binding affinity to human factor D as determined in a SPR assay | - | 9 | pKd | 1 | nM | Kd | J Med Chem (2018) 61: 3253-3276 [PMID:28977749] |
| ChEMBL | Binding affinity to human factor D by SPR analysis | B | 9 | pKd | <1 | nM | Kd | J Med Chem (2018) 61: 3253-3276 [PMID:28977749] |
| ChEMBL | Inhibition of human factor D using C3b as substrate assessed as decrease in formation of factor B cleavage product Ba | B | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (2018) 61: 3253-3276 [PMID:28977749] |
| ChEMBL | Inhibition of factor D in human serum assessed as decrease in alternative pathway of complement-mediated hemolysis of PNH erythrocytes | B | 8.4 | pIC50 | 4 | nM | IC50 | J Med Chem (2018) 61: 3253-3276 [PMID:28977749] |
| ChEMBL | Inhibition of factor D in human serum assessed as decrease in C3 deposition on PNH erythrocytes | B | 8.4 | pIC50 | 4 | nM | IC50 | J Med Chem (2018) 61: 3253-3276 [PMID:28977749] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
