danicopan [Ligand Id: 11988] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL4250860 (Ach-0144471, ACH-0144471, ACH-4471, Danicopan)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
complement factor D/Complement factor D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2176771] [GtoPdb: 2842] [UniProtKB: P00746]
GtoPdb Binding affinity to human factor D as determined in a SPR assay - 9 pKd 1 nM Kd J Med Chem (2018) 61: 3253-3276 [PMID:28977749]
ChEMBL Binding affinity to human factor D by SPR analysis B 9 pKd <1 nM Kd J Med Chem (2018) 61: 3253-3276 [PMID:28977749]
ChEMBL Inhibition of human factor D using C3b as substrate assessed as decrease in formation of factor B cleavage product Ba B 7.82 pIC50 15 nM IC50 J Med Chem (2018) 61: 3253-3276 [PMID:28977749]
ChEMBL Inhibition of factor D in human serum assessed as decrease in alternative pathway of complement-mediated hemolysis of PNH erythrocytes B 8.4 pIC50 4 nM IC50 J Med Chem (2018) 61: 3253-3276 [PMID:28977749]
ChEMBL Inhibition of factor D in human serum assessed as decrease in C3 deposition on PNH erythrocytes B 8.4 pIC50 4 nM IC50 J Med Chem (2018) 61: 3253-3276 [PMID:28977749]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]