sulfaguanidine [Ligand Id: 12639] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL338802 (Gppe susp fte, Guanimycin, NSC-14041, Sulfaguanidina, Sulfaguanidine, Sulphaguanidine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] | ||||||||
| ChEMBL | Inhibitory concentration against human cystolic isozyme II of Carbonic anhydrase | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5703-5707 [PMID:15482952] |
| carbonic anhydrase 5A/Carbonic anhydrase VA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218] | ||||||||
| ChEMBL | Inhibitory concentration against human cystolic isozyme V of Carbonic anhydrase | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5703-5707 [PMID:15482952] |
| Protein argonaute-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4680043] [UniProtKB: Q9UKV8] | ||||||||
| ChEMBL | Binding affinity to human Argonaut protein 2 PAZ domain assessed as dissociation constant by using isothermal titration microcalorimetry | B | 4.31 | pKd | 49000 | nM | Kd | Bioorg Med Chem Lett (2020) 30: 127637-127637 [PMID:33132114] |
| coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734] | ||||||||
| ChEMBL | Inhibitory activity against human thrombin (using Chromozym TH as the substrate) | B | 7.02 | pKi | 95 | nM | Ki | J Med Chem (2000) 43: 1793-1806 [PMID:10794696] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
