TAK-220 [Ligand Id: 800] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL207004 (TAK-220) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| CCR5/C-C chemokine receptor type 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL274] [GtoPdb: 62] [UniProtKB: P51681] | ||||||||
| ChEMBL | Inhibition of [125I]RANTES binding to human CCR5 expressed in CHO cells | B | 8.46 | pIC50 | 3.5 | nM | IC50 | J Med Chem (2006) 49: 2784-2793 [PMID:16640339] |
| GtoPdb | - | - | 8.5 | pIC50 | - | - | - | J Med Chem (2006) 49: 2784-93 [PMID:16640339] |
| ChEMBL | Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5 | F | 9.38 | pIC50 | 0.42 | nM | IC50 | J Med Chem (2006) 49: 2784-2793 [PMID:16640339] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
