TAK-220 [Ligand Id: 800] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL207004 (TAK-220) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| CCR5/C-C chemokine receptor type 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL274] [GtoPdb: 62] [UniProtKB: P51681] | ||||||||
| ChEMBL | Inhibition of [125I]RANTES binding to human CCR5 expressed in CHO cells | B | 8.46 | pIC50 | 3.5 | nM | IC50 | J Med Chem (2006) 49: 2784-2793 [PMID:16640339] |
| GtoPdb | - | - | 8.5 | pIC50 | - | - | - | J Med Chem (2006) 49: 2784-93 [PMID:16640339] |
| ChEMBL | Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5 | F | 9.38 | pIC50 | 0.42 | nM | IC50 | J Med Chem (2006) 49: 2784-2793 [PMID:16640339] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
