umifenovir [Ligand Id: 11089] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1214598 (Arbidol, Umifenovir)
  • Hemagglutinin in Influenza A virus (A/Puerto Rico/8/1934(H1N1)) [ChEMBL: CHEMBL1075313] [UniProtKB: P03452]
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  • CoV Spike glycoprotein/Spike glycoprotein in Severe acute respiratory syndrome coronavirus 2 [ChEMBL: CHEMBL4662936] [GtoPdb: 3114] [UniProtKB: P0DTC2]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Hemagglutinin in Influenza A virus (A/Puerto Rico/8/1934(H1N1)) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075313] [UniProtKB: P03452]
ChEMBL Binding affinity to Influenza A virus (A/Puerto Rico/8/1934(H1N1)) Hemagglutinin at 1.5625 to 50 uM by SPR assay B 4.95 pKd 11100 nM Kd J Med Chem (2020) 63: 6924-6940 [PMID:32520560]
CoV Spike glycoprotein/Spike glycoprotein in Severe acute respiratory syndrome coronavirus 2 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4662936] [GtoPdb: 3114] [UniProtKB: P0DTC2]
ChEMBL Inhibition of SARS-COV2 spike protein mediated infection of human ACE2 expressing cells at 50 uM by SPR analysis B 5.39 pIC50 4110 nM IC50 J Med Chem (2020) 63: 12256-12274 [PMID:32539378]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]