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ChEMBL ligand: CHEMBL436 (Alderase, Alredase, AY-27,773, AY-27773, Tolrestat) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Aldehyde reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2246] [UniProtKB: P14550] | ||||||||
ChEMBL | In vitro inhibition of recombinant human aldehyde reductase | B | 5.71 | pIC50 | 1940 | nM | IC50 | J Med Chem (2005) 48: 3141-3152 [PMID:15857120] |
ChEMBL | Inhibition of N-terminal 6His-tagged human aldehyde reductase expressed in Escherichia coli BL21(DE3) mediated D-glucuronate reduction | B | 6.14 | pIC50 | 720 | nM | IC50 | Bioorg Med Chem (2010) 18: 2485-2490 [PMID:20304656] |
Aldehyde reductase in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4049] [UniProtKB: P50578] | ||||||||
ChEMBL | Inhibition of pig ALR1 | B | 5.66 | pIC50 | 2190 | nM | IC50 | Bioorg Med Chem (2009) 17: 1244-1250 [PMID:19121944] |
ChEMBL | Selectivity ratio measured as the IC50 ratio of aldehyde/aldose reductase values | B | 6.27 | pIC50 | 540 | nM | IC50 | J Med Chem (1991) 34: 1011-1018 [PMID:1900532] |
Aldehyde reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3871] [UniProtKB: P51635] | ||||||||
ChEMBL | Evaluated for inhibition of Aldehyde reductase 1 | B | 5.92 | pIC50 | 1210 | nM | IC50 | J Med Chem (1996) 39: 4396-4405 [PMID:8893834] |
Aldo-keto reductase family 1 member B10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5983] [UniProtKB: O60218] | ||||||||
ChEMBL | Inhibition of reductase activity of N-terminal 6His-tagged human AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as pyridine-3-aldehyde reduction | B | 7.3 | pKi | 50 | nM | Ki | J Nat Prod (2011) 74: 1201-1206 [PMID:21561086] |
ChEMBL | Inhibition of reductase activity of N-terminal 6His-tagged AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as inhibition of NADPH linked pyridine-3-aldehyde reduction | B | 7.27 | pIC50 | 54 | nM | IC50 | Bioorg Med Chem (2010) 18: 2485-2490 [PMID:20304656] |
ChEMBL | Inhibition of human N-terminal His-tagged AKR1B10 expressed in Escherichia coli BL21 using retinaldehyde as substrate | B | 7.27 | pIC50 | 54 | nM | IC50 | J Med Chem (2017) 60: 8441-8455 [PMID:28976752] |
ChEMBL | Inhibition of retinaldehyde reductase activity of human AKR1B10 | B | 7.94 | pIC50 | 11.6 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20764-20769 [PMID:18087047] |
Aldo-keto reductase family 1 member C21 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075270] [UniProtKB: Q91WR5] | ||||||||
ChEMBL | Inhibition of mouse recombinant AKR1C21 | B | 4.66 | pKi | 22000 | nM | Ki | Bioorg Med Chem (2008) 16: 3245-3254 [PMID:18165015] |
ChEMBL | Inhibition of mouse recombinant AKR1C21 | B | 4.32 | pIC50 | 48000 | nM | IC50 | Bioorg Med Chem (2008) 16: 3245-3254 [PMID:18165015] |
aldo-keto reductase family 1 member B/Aldose reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121] | ||||||||
ChEMBL | In vitro inhibitory activity against recombinant human aldose reductase (ALR2) was determined | B | 6.4 | pIC50 | 400 | nM | IC50 | J Med Chem (2003) 46: 5208-5221 [PMID:14613323] |
ChEMBL | Inhibitory Activity against Human recombinant Aldose Reductase (wild type) | B | 7.33 | pIC50 | 47 | nM | IC50 | J Med Chem (2000) 43: 1062-1070 [PMID:10737739] |
GtoPdb | - | - | 7.33 | pIC50 | 47 | nM | IC50 | J Med Chem (2000) 43: 1062-70 [PMID:10737739] |
ChEMBL | Inhibition of human recombinant aldose reductase | B | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg Med Chem (2008) 16: 3245-3254 [PMID:18165015] |
ChEMBL | Inhibitory activity against aldose reductase enzyme | B | 7.46 | pIC50 | 35 | nM | IC50 | J Med Chem (2003) 46: 417-426 [PMID:12540241] |
ChEMBL | Compound was evaluated In vitro for inhibition of aldose reductase activity by 50% in dog RBC | B | 7.62 | pIC50 | 23.9 | nM | IC50 | J Med Chem (1994) 37: 2043-2058 [PMID:8027986] |
ChEMBL | In vitro inhibition of recombinant human aldose reductase expressed in Escherichia coli | B | 7.89 | pIC50 | 13 | nM | IC50 | J Med Chem (2005) 48: 3141-3152 [PMID:15857120] |
ChEMBL | Inhibition of N-terminal 6His-tagged human aldose reductase expressed in Escherichia coli BL21(DE3) mediated NADPH linked pyridine-3-aldehyde reduction | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem (2010) 18: 2485-2490 [PMID:20304656] |
ChEMBL | Inhibition of human AKR1B1 assessed as decrease in glyceraldehyde reduction | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2017) 60: 8441-8455 [PMID:28976752] |
Aldose reductase in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4559] [UniProtKB: P80276] | ||||||||
ChEMBL | Inhibition of pig kidney aldose reductase (ALR2) | B | 4.8 | pIC50 | 16000 | nM | IC50 | J Med Chem (2003) 46: 5619-5627 [PMID:14667216] |
ChEMBL | Inhibition of aldose reductase from pig lenses | B | 7.52 | pIC50 | 30 | nM | IC50 | J Med Chem (2004) 47: 5076-5084 [PMID:15456251] |
ChEMBL | Inhibitory concentration against porcine lens aldose reductase (AR) with DL-glyceraldehyde as the substrate | B | 7.8 | pIC50 | 16 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 1677-1682 |
ChEMBL | In vitro inhibitory activity against aldose reductase in porcine lens. | B | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (1998) 41: 4118-4129 [PMID:9767647] |
Aldose reductase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3081] [UniProtKB: P16116] | ||||||||
ChEMBL | Evaluated for inhibition of Aldose reductase 2 | B | 7.02 | pIC50 | 96 | nM | IC50 | J Med Chem (1996) 39: 4396-4405 [PMID:8893834] |
ChEMBL | In vitro inhibition of aldose reductase from the partially purified bovine lens | B | 7.46 | pIC50 | 35 | nM | IC50 | J Med Chem (1990) 33: 2892-2899 [PMID:2120443] |
ChEMBL | Inhibition of bovine lens aldose reductase with DL-glyceraldehyde as substrate | B | 7.46 | pIC50 | 35 | nM | IC50 | J Med Chem (1984) 27: 255-256 [PMID:6422042] |
ChEMBL | In vitro inhibition of bovine lens aldose reductase | B | 7.46 | pIC50 | 35 | nM | IC50 | J Med Chem (1989) 32: 757-765 [PMID:2539477] |
ChEMBL | inhibition of aldose reductase activity was measured on partially purified bovine lens preparations incubated in presence of 50 mM glucose. | B | 7.47 | pIC50 | 34 | nM | IC50 | J Med Chem (1991) 34: 2504-2520 [PMID:1908522] |
ChEMBL | In vitro inhibition of aldose reductase in partially purified bovine lens preparation at a concentration of 10e -8M. | B | 7.48 | pIC50 | 33 | nM | IC50 | J Med Chem (1991) 34: 1492-1503 [PMID:1901912] |
ChEMBL | In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparation | B | 7.48 | pIC50 | 33 | nM | IC50 | J Med Chem (1994) 37: 2043-2058 [PMID:8027986] |
aldo-keto reductase family 1 member B/Aldose reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943] | ||||||||
ChEMBL | Inhibition of rat AKR1B4 | B | 6 | pIC50 | 1000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20764-20769 [PMID:18087047] |
ChEMBL | In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK) | B | 6.02 | pIC50 | 950 | nM | IC50 | J Med Chem (1991) 34: 3229-3234 [PMID:1956041] |
ChEMBL | Inhibition of aldose reductase (or polyol accumulation) in isolated rat sciatic nerve by compound at 10e-5 M concentration | B | 6.27 | pIC50 | 540 | nM | IC50 | J Med Chem (1989) 32: 757-765 [PMID:2539477] |
ChEMBL | Inhibition of Albino rat eye lens ALR2 assessed as NADPH oxidation by spectrophotometry | B | 7.3 | pIC50 | 50 | nM | IC50 | Eur J Med Chem (2010) 45: 909-914 [PMID:19962793] |
ChEMBL | Inhibition of Sprague-Dawley rat lens ALR2 using D,L-glyceraldehyde as substrate preincubated for 10 mins followed by substrate addition measured for 5 mins by spectrophotometric method | B | 7.3 | pIC50 | 50 | nM | IC50 | Bioorg Med Chem (2017) 25: 3068-3076 [PMID:28392277] |
ChEMBL | In vitro inhibitory activity against aldose reductase (ALR2) from rat lens extraction. | B | 7.3 | pIC50 | 50 | nM | IC50 | J Med Chem (2003) 46: 1419-1428 [PMID:12672241] |
ChEMBL | Inhibitory concentration to aldose reductase (ALR-2) obtained from rat lens | B | 7.3 | pIC50 | 50 | nM | IC50 | J Med Chem (2001) 44: 4359-4369 [PMID:11728182] |
ChEMBL | In vitro inhibitory activity against aldose reductase (ALR2) from rat lens extraction. | B | 7.34 | pIC50 | 46 | nM | IC50 | J Med Chem (2003) 46: 1419-1428 [PMID:12672241] |
ChEMBL | Inhibitory activity measured against rat lens aldose reductase using 3-pyridinecarboxaldehyde as substrate | B | 8.54 | pIC50 | 2.9 | nM | IC50 | J Med Chem (1991) 34: 1011-1018 [PMID:1900532] |
ChEMBL | In vitro inhibition of Aldose reductase (AR) from rat lens (RL) | B | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (1991) 34: 3229-3234 [PMID:1956041] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]