reactive blue-2 [Ligand Id: 1739] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1160031 (Reactive Blue 2)
  • choline O-acetyltransferase/Choline acetylase in Human [ChEMBL: CHEMBL4039] [GtoPdb: 2480] [UniProtKB: P28329]
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  • Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 in Human [ChEMBL: CHEMBL5925] [UniProtKB: P22413]
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  • P2Y2 receptor in Human [GtoPdb: 324] [UniProtKB: P41231]
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  • P2Y4 receptor in Rat [GtoPdb: 325] [UniProtKB: O35811]
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  • P2Y6 receptor in Human [GtoPdb: 326] [UniProtKB: Q15077]
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  • P2Y11 receptor in Human [GtoPdb: 327] [UniProtKB: Q96G91]
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  • P2Y13 receptor in Human [GtoPdb: 329] [UniProtKB: Q9BPV8]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
choline O-acetyltransferase/Choline acetylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4039] [GtoPdb: 2480] [UniProtKB: P28329]
ChEMBL Inhibition of choline acetyltransferase isolated from squid head ganglia B 6.1 pKi 800 nM Ki J. Med. Chem. (1981) 24: 1534-1537 [PMID:7310833]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5925] [UniProtKB: P22413]
ChEMBL Competitive inhibition of human NPP1 expressed in African green monkey COS7 cells using ATP as substrate after 20 mins by Michaelis-Menten plot analysis B 6.28 pKi 520 nM Ki Bioorg. Med. Chem. (2016) 24: 3157-3165 [PMID:27265686]
P2Y2 receptor in Human [GtoPdb: 324] [UniProtKB: P41231]
GtoPdb - - 6 pIC50 - - - Br J Pharmacol (1999) 127: 709-16 [PMID:10401562]
P2Y4 receptor in Rat [GtoPdb: 325] [UniProtKB: O35811]
GtoPdb - - 4.7 pIC50 - - - Br J Pharmacol (1998) 124: 428-30 [PMID:9647463]
P2Y6 receptor in Human [GtoPdb: 326] [UniProtKB: Q15077]
GtoPdb - - 4.5 pIC50 31000 nM IC50 Curr Med Chem (2006) 13: 289-312 [PMID:16475938]
P2Y11 receptor in Human [GtoPdb: 327] [UniProtKB: Q96G91]
GtoPdb - - 5 pIC50 - - - Br J Pharmacol (1999) 128: 1199-206 [PMID:10578132]
P2Y13 receptor in Human [GtoPdb: 329] [UniProtKB: Q9BPV8]
GtoPdb - - 5.7 pIC50 - - - Mol Pharmacol (2003) 64: 104-12 [PMID:12815166]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]