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ChEMBL ligand: CHEMBL59 (A-dopamine, Dobutamine a, Dopamine, Intropin, Medopa, NSC-173182, Oxytyramine) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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A2B receptor/Adenosine A2b receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2592] [GtoPdb: 20] [UniProtKB: P29276] | ||||||||
ChEMBL | Compound was tested for its binding affinity against Alpha-2 adrenergic receptor | B | 6.01 | pKi | 977.24 | nM | Ki | Bioorg Med Chem Lett (1995) 5: 2371-2376 |
synuclein alpha/Alpha-synuclein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6152] [GtoPdb: 3285] [UniProtKB: P37840] | ||||||||
ChEMBL | Inhibition of human alpha-synuclein filament formation expressed in Escherichia coli BL21(DE3) cells incubated for 72 hrs by thioflavin S based fluorescence assay | B | 5.15 | pIC50 | 7100 | nM | IC50 | Eur J Med Chem (2019) 167: 10-36 [PMID:30743095] |
ChEMBL | Inhibition of alpha-synuclein fibril formation (unknown origin) incubated for 6 days by thioflavin S based fluorescence assay | B | 6.28 | pIC50 | 530 | nM | IC50 | Eur J Med Chem (2019) 167: 10-36 [PMID:30743095] |
β1-adrenoceptor/Beta-1 adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3252] [GtoPdb: 28] [UniProtKB: P18090] | ||||||||
ChEMBL | Binding of [3H]dihydroalprenolol to beta-1 adrenergic receptor of rat cerebral cortical membranes | B | 5 | pKi | 10000 | nM | Ki | J Med Chem (2000) 43: 1611-1619 [PMID:10780918] |
β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550] | ||||||||
ChEMBL | Binding affinity to human adrenergic beta2 receptor | B | 4.19 | pKd | 64560 | nM | Kd | Eur J Med Chem (2009) 44: 2840-2846 [PMID:19168263] |
ChEMBL | Displacement of [3H]CGP12177 from human beta2 receptor expressed in CHO cells | B | 4.21 | pKi | 61000 | nM | Ki | Bioorg Med Chem (2016) 24: 2641-2653 [PMID:27132867] |
Beta-2 adrenergic receptor in Dog (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2289] [UniProtKB: P54833] | ||||||||
ChEMBL | Binding of [3H]dihydroalprenolol to beta-2 adrenergic receptor of rat cerebral cortical membranes | B | 4.3 | pKi | 50000 | nM | Ki | J Med Chem (2000) 43: 1611-1619 [PMID:10780918] |
cyclic AMP phosphoprotein in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2170] [UniProtKB: Q712U5] | ||||||||
ChEMBL | Effective concentration that gives maximal stimulation of cyclic AMP production over the concentration range tested. | F | 5.46 | pEC50 | 3500 | nM | EC50 | J Med Chem (1984) 27: 28-35 [PMID:6317860] |
D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728] | ||||||||
ChEMBL | Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells | B | 5.6 | pKd | 2500 | nM | Kd | J Med Chem (1996) 39: 850-859 [PMID:8632409] |
ChEMBL | Affinity towards Dopamine receptor D1 | B | 4.74 | pKi | 18200 | nM | Ki | J Med Chem (1998) 41: 4385-4399 [PMID:9784114] |
ChEMBL | Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells | B | 4.92 | pKi | 12000 | nM | Ki | Eur J Med Chem (2012) 55: 255-261 [PMID:22846798] |
ChEMBL | Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis | B | 4.92 | pKi | 12000 | nM | Ki | Bioorg Med Chem (2013) 21: 4143-4150 [PMID:23727194] |
ChEMBL | Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cells | B | 5.35 | pKi | 4470 | nM | Ki | J Med Chem (2012) 55: 10302-10306 [PMID:23134120] |
GtoPdb | - | - | 5.6 | pKi | - | - | - |
Nature (1991) 350: 614-9 [PMID:1826762]; J Biol Chem (1994) 269: 27925-31 [PMID:7525564] |
ChEMBL | Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting | B | 6.61 | pKi | 243 | nM | Ki | J Med Chem (2018) 61: 11384-11397 [PMID:30431269] |
ChEMBL | Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1 | B | 6.72 | pKi | 192 | nM | Ki | J Med Chem (1990) 33: 2197-2204 [PMID:1973733] |
ChEMBL | Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells | B | 6.89 | pKi | 130 | nM | Ki | J Med Chem (1995) 38: 3445-3447 [PMID:7658429] |
ChEMBL | Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting | B | 6.91 | pKi | 124 | nM | Ki | Bioorg Med Chem (2009) 17: 4756-4762 [PMID:19454369] |
ChEMBL | Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay | B | 5.85 | pEC50 | 1400 | nM | EC50 | ACS Med Chem Lett (2019) 10: 792-799 [PMID:31098001] |
ChEMBL | Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay | F | 6.63 | pEC50 | 232 | nM | EC50 | J Med Chem (2018) 61: 11384-11397 [PMID:30431269] |
ChEMBL | Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production | F | 6.92 | pEC50 | 120 | nM | EC50 | J Med Chem (2006) 49: 6848-6857 [PMID:17154515] |
ChEMBL | Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1 | B | 7 | pEC50 | 100 | nM | EC50 | J Med Chem (1995) 38: 3445-3447 [PMID:7658429] |
ChEMBL | Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay | F | 7.36 | pEC50 | 44 | nM | EC50 | ACS Med Chem Lett (2019) 10: 792-799 [PMID:31098001] |
ChEMBL | Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins | F | 7.41 | pEC50 | 39 | nM | EC50 | Bioorg Med Chem (2014) 22: 381-392 [PMID:24296012] |
ChEMBL | Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production | F | 7.46 | pEC50 | 35 | nM | EC50 | Bioorg Med Chem (2008) 16: 3438-3444 [PMID:18313303] |
ChEMBL | Agonist activity at human D1 receptor assessed as cAMP accumulation | F | 7.7 | pEC50 | 20 | nM | EC50 | Bioorg Med Chem (2010) 18: 6763-6770 [PMID:20709559] |
Dopamine D1 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2967] [UniProtKB: Q95136] | ||||||||
ChEMBL | Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand | B | 5.37 | pKi | 4300 | nM | Ki | J Med Chem (1998) 41: 4933-4938 [PMID:9836610] |
ChEMBL | Binding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retina | B | 5.37 | pKi | 4300 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 223-226 [PMID:11206464] |
ChEMBL | Binding Affinity was determined for its ability to displace the radioligand [3H]-SCH- 23390 from Bovine dopamine receptor D1 | B | 5.8 | pKi | 1600 | nM | Ki | J Med Chem (2000) 43: 756-762 [PMID:10691700] |
ChEMBL | Binding Affinity was tested on low Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site. | B | 6.19 | pKi | 650 | nM | Ki | J Med Chem (2000) 43: 756-762 [PMID:10691700] |
ChEMBL | Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum | B | 6.36 | pKi | 440 | nM | Ki | Bioorg Med Chem (2013) 21: 1680-1684 [PMID:23428965] |
ChEMBL | Binding Affinity was tested on relative proportion of High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site. | B | 7.44 | pKi | 36 | nM | Ki | J Med Chem (2000) 43: 756-762 [PMID:10691700] |
ChEMBL | Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 | B | 8.15 | pKi | 7 | nM | Ki | J Med Chem (2000) 43: 756-762 [PMID:10691700] |
ChEMBL | In vitro binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligand | B | 6.7 | pIC50 | 200 | nM | IC50 | Bioorg Med Chem Lett (1991) 1: 403-406 |
D1 receptor/Dopamine D1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901] | ||||||||
ChEMBL | Affinity for Dopamine receptor D1 binding sites was evaluated in a test involving displacement of [3H]- fenoldopam in rat striatum | B | 6.82 | pKd | 0.15 | uM | K Bind | J Med Chem (1986) 29: 1615-1627 [PMID:2875183] |
ChEMBL | In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate. | B | 5.36 | pKi | 4400 | nM | Ki | J Med Chem (1986) 29: 1889-1895 [PMID:3761308] |
ChEMBL | Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement. | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (1996) 39: 4238-4246 [PMID:8863801] |
ChEMBL | Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand. | B | 6.38 | pKi | 416.87 | nM | Ki | J Med Chem (2000) 43: 599-608 [PMID:10691686] |
ChEMBL | Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390 | B | 6.51 | pKi | 309.03 | nM | Ki | Bioorg Med Chem Lett (1995) 5: 2371-2376 |
ChEMBL | Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes | B | 6.82 | pKi | 150 | nM | Ki | J Med Chem (1986) 29: 1904-1912 [PMID:3761310] |
ChEMBL | Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane | B | 5.43 | pIC50 | 3700 | nM | IC50 | J Med Chem (1992) 35: 4408-4414 [PMID:1360027] |
ChEMBL | Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes | B | 5.52 | pIC50 | 3000 | nM | IC50 | J Med Chem (1990) 33: 2408-2412 [PMID:1975274] |
ChEMBL | Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum | B | 6.1 | pIC50 | 800 | nM | IC50 | J Med Chem (1990) 33: 1756-1764 [PMID:1971308] |
ChEMBL | Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity | F | 5.3 | pEC50 | 5000 | nM | EC50 | J Med Chem (1996) 39: 285-296 [PMID:8568818] |
ChEMBL | Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes | F | 5.46 | pEC50 | 3500 | nM | EC50 | J Med Chem (1987) 30: 1166-1176 [PMID:2955118] |
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
ChEMBL | Binding Affinity was determined in the presence of 100 micro M Gpp(NH)p for decoupling of the ternary complex of Compound to Dopamine receptor D2S | B | 4.82 | pKi | 15000 | nM | Ki | J Med Chem (2000) 43: 756-762 [PMID:10691700] |
ChEMBL | Binding Affinity was determined in the presence of 100 micro M Gpp(NH)p for decoupling of the ternary complex of Compound to Dopamine receptor D2L | B | 4.82 | pKi | 15000 | nM | Ki | J Med Chem (2000) 43: 756-762 [PMID:10691700] |
ChEMBL | Affinity towards Dopamine receptor D2 | B | 5.1 | pKi | 7940 | nM | Ki | J Med Chem (1998) 41: 4385-4399 [PMID:9784114] |
ChEMBL | Displacement of [3H]N-methylspiperone from human D2 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counter | B | 5.43 | pKi | 3690 | nM | Ki | J Med Chem (2016) 59: 2973-2988 [PMID:27035329] |
ChEMBL | Displacement of [3H]-NPA from dopamine D2L receptor (unknown origin) expressed in CHO cell membranes | B | 5.47 | pKi | 3420 | nM | KiL | J Med Chem (2013) 56: 9199-9221 [PMID:24138311] |
ChEMBL | Displacement of [3H]spiperone from human dopamine D2 receptor at low affinity state expressed in HEK293 cells | B | 5.68 | pKi | 2100 | nM | Ki | J Med Chem (2010) 53: 2510-2520 [PMID:20155917] |
ChEMBL | Displacement of [3H]raclopride from human dopamine D2L receptor expressed in HEK293 cells by scintillation counting analysis | B | 5.68 | pKi | 2100 | nM | Ki | Bioorg Med Chem (2013) 21: 4143-4150 [PMID:23727194] |
ChEMBL | Displacement of [3H]raclopride from human D2L receptor expressed in HEK293 cells | B | 5.68 | pKi | 2100 | nM | Ki | Eur J Med Chem (2012) 55: 255-261 [PMID:22846798] |
ChEMBL | Binding Affinity was tested on low Affinity Site of Dopamine receptor D2L | B | 5.72 | pKi | 1900 | nM | Ki | J Med Chem (2000) 43: 756-762 [PMID:10691700] |
ChEMBL | Binding Affinity of Compound of Dopamine receptor D2S | B | 5.96 | pKi | 1100 | nM | Ki | J Med Chem (2000) 43: 756-762 [PMID:10691700] |
ChEMBL | Displacement of [3H]raclopride from human dopamine D2A receptors expressed in LtK cells | B | 6.12 | pKi | 759 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 2167-2172 [PMID:10465538] |
ChEMBL | Inhibition of [3H]raclopride binding to Dopamine receptor D2 | B | 6.24 | pKi | 572 | nM | Ki | J Med Chem (1996) 39: 4421-4429 [PMID:8893836] |
ChEMBL | Displacement of [3H]spiperone from human D2long receptor expressed in CHO cells | B | 6.35 | pKi | 450 | nM | Ki | J Med Chem (2008) 51: 6829-6838 [PMID:18834111] |
ChEMBL | Displacement of [3H]YM-09151-2 from human dopamine D2 receptor expressed in CHOp cells | B | 6.37 | pKi | 422 | nM | Ki | J Med Chem (2012) 55: 10302-10306 [PMID:23134120] |
ChEMBL | Displacement of [3H]spiperone from human D2short receptor expressed in CHO cells | B | 6.44 | pKi | 360 | nM | Ki | J Med Chem (2008) 51: 6829-6838 [PMID:18834111] |
ChEMBL | Binding affinity against cloned human Dopamine receptor D2 using [3H]spiperone as radioligand transfected in HEK cells | B | 6.59 | pKi | 260 | nM | Ki | J Med Chem (1995) 38: 3445-3447 [PMID:7658429] |
ChEMBL | Displacement of [3H]spiperone from human dopamine D2long receptor expressed in CHO cells | B | 6.72 | pKi | 190 | nM | Ki | Bioorg Med Chem (2013) 21: 1680-1684 [PMID:23428965] |
ChEMBL | Displacement of [3H]spiperone from human dopamine D2short receptor expressed in CHO cells | B | 6.96 | pKi | 110 | nM | Ki | Bioorg Med Chem (2013) 21: 1680-1684 [PMID:23428965] |
GtoPdb | - | - | 7.2 | pKi | - | - | - |
J Pharmacol Exp Ther (1994) 268: 417-26 [PMID:8301582]; Neuroreport (1995) 6: 329-332 [PMID:7756621]; Neuropsychopharmacology (1995) 12: 335-45 [PMID:7576010] |
ChEMBL | Displacement of [3H]-NPA from dopamine D2L receptor (unknown origin) expressed in CHO cell membranes | B | 7.24 | pKi | 58 | nM | KiH | J Med Chem (2013) 56: 9199-9221 [PMID:24138311] |
ChEMBL | Displacement of [3H]spiperone from human D2S receptor expressed in CHO cells | B | 7.32 | pKi | 48 | nM | Ki | Bioorg Med Chem (2016) 24: 2641-2653 [PMID:27132867] |
ChEMBL | Binding Affinity was tested on relative proportion of High Affinity Site of Dopamine receptor D2L | B | 7.38 | pKi | 42 | nM | Ki | J Med Chem (2000) 43: 756-762 [PMID:10691700] |
ChEMBL | Binding Affinity was tested on relative proportion of High Affinity Site of Dopamine receptor D2S | B | 7.47 | pKi | 34 | nM | Ki | J Med Chem (2000) 43: 756-762 [PMID:10691700] |
ChEMBL | Binding affinity on High Affinity Site of Dopamine receptor D2L | B | 7.7 | pKi | 20 | nM | Ki | J Med Chem (2000) 43: 756-762 [PMID:10691700] |
ChEMBL | Binding Affinity on High Affinity Site of Dopamine receptor D2S | B | 7.77 | pKi | 17 | nM | Ki | J Med Chem (2000) 43: 756-762 [PMID:10691700] |
ChEMBL | Displacement of [3H]-(R)-(+)-7-OH-DPAT from human dopamine D2 receptor expressed in HEK293 cell membranes after 90 mins by micro beta scintillation counting analysis | B | 7.8 | pKi | 16 | nM | Ki | J Med Chem (2017) 60: 2890-2907 [PMID:28300398] |
ChEMBL | Displacement of [3H]7-OH-DPAT from human D2 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counter | B | 8.06 | pKi | 8.73 | nM | Ki | J Med Chem (2016) 59: 2973-2988 [PMID:27035329] |
ChEMBL | Displacement of [3H]-NPA from dopamine D2L receptor (unknown origin) expressed in CHO cell membranes | B | 8.1 | pKi | 8 | nM | Ki | J Med Chem (2013) 56: 9199-9221 [PMID:24138311] |
ChEMBL | Displacement of [3H]spiperone from human dopamine D2 receptor at high affinity state expressed in HEK293 cells | B | 8.54 | pKi | 2.9 | nM | Ki | J Med Chem (2010) 53: 2510-2520 [PMID:20155917] |
ChEMBL | Displacement of [3H]quinpirole from Dopamine receptor D2 | B | 8.72 | pKi | 1.89 | nM | Ki | J Med Chem (1996) 39: 4421-4429 [PMID:8893836] |
ChEMBL | Displacement of [3H]quinpirole from human dopamine D2A receptors expressed in LtK cells | B | 8.72 | pKi | 1.89 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 2167-2172 [PMID:10465538] |
ChEMBL | Agonist activity at human dopamine D2 short receptor transiently expressed in HEK293 cells co-expressing Galphai2 after 30 mins by [35S]GTPgammaS binding assay | F | 6.33 | pEC50 | 470 | nM | EC50 | J Med Chem (2014) 57: 4861-4875 [PMID:24831693] |
ChEMBL | Agonist activity at human dopamine D2 short receptor transiently expressed in HEK293 cells co-expressing Galphai2 after 30 mins by [35S]GTPgammaS binding assay | F | 6.33 | pEC50 | 467.74 | nM | EC50 | J Med Chem (2014) 57: 4861-4875 [PMID:24831693] |
ChEMBL | Partial agonist activity at human D2SR expressed in HEK293T cells co-expressing (EA)beta-arrestin2 assessed as induction of beta-arrestin2 recruitment after 5 hrs by chemiluminescence assay | B | 6.41 | pEC50 | 390 | nM | EC50 | J Med Chem (2017) 60: 4693-4713 [PMID:28489379] |
ChEMBL | Agonist activity at human D2 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assay | F | 6.42 | pEC50 | 376 | nM | EC50 | Bioorg Med Chem (2016) 24: 5088-5102 [PMID:27591013] |
ChEMBL | Agonist activity at human cloned dopamine D2 receptor expressed in CHO cells by [35S]GTP gammaS binding assay | F | 6.62 | pEC50 | 240 | nM | EC50 | ACS Med Chem Lett (2012) 3: 991-996 [PMID:23275802] |
ChEMBL | Agonist activity at human dopamine D2L receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysis | F | 6.64 | pEC50 | 227 | nM | EC50 | Bioorg Med Chem (2013) 21: 3164-3174 [PMID:23623679] |
ChEMBL | Agonist activity at human cloned dopamine D2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay | F | 6.64 | pEC50 | 227 | nM | EC50 | J Med Chem (2012) 55: 5826-5840 [PMID:22642365] |
ChEMBL | Agonist activity at N-terminal flag-tagged D2S receptor (unknown origin) expressed in HEK293 cells assessed as induction of renilla luciferase 2-tagged beta-arrestin-1 recruitment after 15 mins by BRET assay | B | 6.65 | pEC50 | 226 | nM | EC50 | J Med Chem (2017) 60: 2908-2929 [PMID:28248104] |
ChEMBL | Agonist activity at human dopamine D2 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding | F | 6.66 | pEC50 | 218 | nM | EC50 | J Med Chem (2014) 57: 1557-1572 [PMID:24471976] |
ChEMBL | Agonist activity at human dopamine D2 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding | F | 6.68 | pEC50 | 209 | nM | EC50 | Bioorg Med Chem (2010) 18: 5661-5674 [PMID:20605099] |
ChEMBL | Agonist activity at human cloned dopamine D2L receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding | F | 6.68 | pEC50 | 209 | nM | EC50 | J Med Chem (2008) 51: 101-117 [PMID:18072730] |
ChEMBL | Agonist activity at human dopamine D2L receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding | F | 6.68 | pEC50 | 209 | nM | EC50 | J Med Chem (2008) 51: 3005-3019 [PMID:18410082] |
ChEMBL | Activity at human dopamine D2L receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding | F | 6.68 | pEC50 |