dihydromorphine [Ligand Id: 1616] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1500 (Dihydromorphine)
  • δ receptor in Human [GtoPdb: 317] [UniProtKB: P41143]
  • δ receptor/Delta opioid receptor in Rat [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533]
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  • κ receptor in Human [GtoPdb: 318] [UniProtKB: P41145]
  • κ receptor/Kappa opioid receptor in Rat [ChEMBL: CHEMBL3614] [GtoPdb: 318] [UniProtKB: P34975]
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  • μ receptor in Human [GtoPdb: 319] [UniProtKB: P35372]
  • μ receptor/Mu opioid receptor in Rat [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
δ receptor in Human [GtoPdb: 317] [UniProtKB: P41143]
GtoPdb - - 6.7 pKi - - - NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]
δ receptor/Delta opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533]
ChEMBL Affinity against the Opioid receptor delta 1 B 7 pKd 100 nM Kd J Med Chem (1986) 29: 531-537 [PMID:3007760]
κ receptor in Human [GtoPdb: 318] [UniProtKB: P41145]
GtoPdb - - 7.1 pKi - - - NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]
κ receptor/Kappa opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3614] [GtoPdb: 318] [UniProtKB: P34975]
ChEMBL Compound was evaluated for Opioid receptor kappa 1 affinity against the receptor site model site 4(kappa) B 6.08 pKd 830 nM Kd J Med Chem (1986) 29: 531-537 [PMID:3007760]
μ receptor in Human [GtoPdb: 319] [UniProtKB: P35372]
GtoPdb - - 8.8 pKi - - - NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]
μ receptor/Mu opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535]
ChEMBL Opioid receptor mu 2 affinity against the receptor site model site 2(mu2) B 8 pKd 10 nM Kd J Med Chem (1986) 29: 531-537 [PMID:3007760]
ChEMBL Evaluated for Opioid receptor mu 1 affinity against the receptor site model site 1(mu1) B 9.7 pKd 0.2 nM Kd J Med Chem (1986) 29: 531-537 [PMID:3007760]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]