AZD1656 [Ligand Id: 7701] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3219124 (Azd 1656, Azd-1656, Azd1656, AZD1656)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG B 4 pIC50 >100000 nM IC50 Medchemcomm (2012) 3: 1077-1081
Glucokinase/Hexokinase type IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3820] [GtoPdb: 2798] [UniProtKB: P35557]
ChEMBL Binding affinity to biotinylated human recombinant glucokinase expressed in Escherichia coli assessed as dissociation rate constant by SPR method B 7.97 pKd 10.8 nM Kd Medchemcomm (2014) 5: 802-807
ChEMBL Inhibition of recombinant human pancreatic glucokinase by G-6-P dehydrogenase assay B 7.21 pEC50 61 nM EC50 Medchemcomm (2012) 3: 1077-1081
GtoPdb - - 7.24 pEC50 57 nM EC50 AZD1656.. astrazeneca.com
ChEMBL Activation of recombinant human glucokinase assessed as formation of glucose-6-phosphate by G6PDH/NADP coupled assay B 7.55 pEC50 28 nM EC50 Medchemcomm (2014) 5: 802-807

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]