ChEMBL ligand: CHEMBL32442
phosphodiesterase 4A/Phosphodiesterase 4A in Human [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4B/Phosphodiesterase 4B in Human [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4C/Phosphodiesterase 4C in Human [ChEMBL: CHEMBL291] [GtoPdb: 1302] [UniProtKB: Q08493] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4D/Phosphodiesterase 4D in Human [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
phosphodiesterase 4A/Phosphodiesterase 4A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815]
GtoPdb	Inhibition of [3H]-R-rolipram binding to recombinant human PDE-4 isoenzyme	-	8.01	pKi	9.7	nM	Ki	Cell Biochem Biophys (1998) 29: 113-32 [PMID:9631241]
ChEMBL	Inhibition of recombinant human PDE4A expressed in Sf9 cells	B	8.4	pKi	4	nM	Ki	J Med Chem (2000) 43: 3820-3823 [PMID:11052785]
ChEMBL	Inhibitory concentration of compound against LPS- induced TNF-alpha production in whole human blood assay	F	4.8	pIC50	16000	nM	IC50	Bioorg Med Chem Lett (2002) 12: 1457-1461 [PMID:12031319]
ChEMBL	Inhibition of recombinant human PDE4A expressed in Sf9 cells	B	5	pIC50	10000	nM	IC50	J Med Chem (2000) 43: 3820-3823 [PMID:11052785]
ChEMBL	In vitro inhibitory activity was determined against human Phosphodiesterase 4 isoform using a construct representing the common region of spliced variants expressed as a GST-fusion protein in Sf 9 cells	B	8.37	pIC50	4.3	nM	IC50	J Med Chem (2003) 46: 2413-2426 [PMID:12773045]
ChEMBL	Inhibitory concentration against human PDE4A isoform using a construct representing the common region of spliced variants expressed as GST-fusion protein in Sf9 cells	B	8.37	pIC50	4.3	nM	IC50	Bioorg Med Chem Lett (2002) 12: 1457-1461 [PMID:12031319]
ChEMBL	Inhibition of GST-tagged PDE4A	B	8.38	pIC50	4.2	nM	IC50	J Med Chem (2008) 51: 5471-5489 [PMID:18686943]
ChEMBL	Inhibition of human Phosphodiesterase 4A isoform using construct representing the common region of spliced variants expressed as GST-fusion proteins in Sf9 cells.	B	8.38	pIC50	4.2	nM	IC50	Bioorg Med Chem Lett (2002) 12: 3009-3013 [PMID:12270195]
ChEMBL	Inhibition of Phosphodiesterase-4A (PDE4)	B	8.4	pIC50	4	nM	IC50	Bioorg Med Chem Lett (2003) 13: 1923-1926 [PMID:12749899]
ChEMBL	Inhibition of human recombinant phosphodiesterase 4A	B	8.4	pIC50	4	nM	IC50	Bioorg Med Chem Lett (2002) 12: 1451-1456 [PMID:12031318]
ChEMBL	Inhibitory activity against PDE4A	B	8.68	pIC50	2.1	nM	IC50	Bioorg Med Chem Lett (2005) 15: 5241-5246 [PMID:16168647]
phosphodiesterase 4B/Phosphodiesterase 4B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343]
GtoPdb	Inhibition of [3H]-R-rolipram binding to recombinant human PDE4B2 isoenzyme	-	8.07	pKi	8.5	nM	Ki	Cell Biochem Biophys (1998) 29: 113-32 [PMID:9631241]
ChEMBL	Inhibitory activity against PDE4B	B	8.85	pIC50	1.4	nM	IC50	Bioorg Med Chem Lett (2005) 15: 5241-5246 [PMID:16168647]
phosphodiesterase 4C/Phosphodiesterase 4C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL291] [GtoPdb: 1302] [UniProtKB: Q08493]
GtoPdb	Inhibition of [3H]-R-rolipram binding to recombinant human PDE4C2 isoenzyme	-	7.72	pKi	18.9	nM	Ki	Cell Biochem Biophys (1998) 29: 113-32 [PMID:9631241]
ChEMBL	Inhibitory activity against PDE4C	B	8.35	pIC50	4.5	nM	IC50	Bioorg Med Chem Lett (2005) 15: 5241-5246 [PMID:16168647]
phosphodiesterase 4D/Phosphodiesterase 4D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499]
GtoPdb	Inhibition of [3H]-R-rolipram binding to recombinant human PDE4D3 isoenzyme	-	8.15	pKi	7.1	nM	Ki	Cell Biochem Biophys (1998) 29: 113-32 [PMID:9631241]
ChEMBL	Inhibitory activity against PDE4D	B	8.68	pIC50	2.1	nM	IC50	Bioorg Med Chem Lett (2005) 15: 5241-5246 [PMID:16168647]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]