ChEMBL ligand: CHEMBL32442
phosphodiesterase 4A/Phosphodiesterase 4A in Human [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4B/Phosphodiesterase 4B in Human [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4C/Phosphodiesterase 4C in Human [ChEMBL: CHEMBL291] [GtoPdb: 1302] [UniProtKB: Q08493] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4D/Phosphodiesterase 4D in Human [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
phosphodiesterase 4A/Phosphodiesterase 4A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815]
GtoPdb	Inhibition of [3H]-R-rolipram binding to recombinant human PDE-4 isoenzyme	-	8.01	pKi	9.7	nM	Ki	Cell Biochem Biophys (1998) 29: 113-32 [PMID:9631241]
ChEMBL	Inhibition of recombinant human PDE4A expressed in Sf9 cells	B	8.4	pKi	4	nM	Ki	J Med Chem (2000) 43: 3820-3823 [PMID:11052785]
ChEMBL	Inhibitory concentration of compound against LPS- induced TNF-alpha production in whole human blood assay	F	4.8	pIC50	16000	nM	IC50	Bioorg Med Chem Lett (2002) 12: 1457-1461 [PMID:12031319]
ChEMBL	Inhibition of recombinant human PDE4A expressed in Sf9 cells	B	5	pIC50	10000	nM	IC50	J Med Chem (2000) 43: 3820-3823 [PMID:11052785]
ChEMBL	In vitro inhibitory activity was determined against human Phosphodiesterase 4 isoform using a construct representing the common region of spliced variants expressed as a GST-fusion protein in Sf 9 cells	B	8.37	pIC50	4.3	nM	IC50	J Med Chem (2003) 46: 2413-2426 [PMID:12773045]
ChEMBL	Inhibitory concentration against human PDE4A isoform using a construct representing the common region of spliced variants expressed as GST-fusion protein in Sf9 cells	B	8.37	pIC50	4.3	nM	IC50	Bioorg Med Chem Lett (2002) 12: 1457-1461 [PMID:12031319]
ChEMBL	Inhibition of GST-tagged PDE4A	B	8.38	pIC50	4.2	nM	IC50	J Med Chem (2008) 51: 5471-5489 [PMID:18686943]
ChEMBL	Inhibition of human Phosphodiesterase 4A isoform using construct representing the common region of spliced variants expressed as GST-fusion proteins in Sf9 cells.	B	8.38	pIC50	4.2	nM	IC50	Bioorg Med Chem Lett (2002) 12: 3009-3013 [PMID:12270195]
ChEMBL	Inhibition of Phosphodiesterase-4A (PDE4)	B	8.4	pIC50	4	nM	IC50	Bioorg Med Chem Lett (2003) 13: 1923-1926 [PMID:12749899]
ChEMBL	Inhibition of human recombinant phosphodiesterase 4A	B	8.4	pIC50	4	nM	IC50	Bioorg Med Chem Lett (2002) 12: 1451-1456 [PMID:12031318]
ChEMBL	Inhibitory activity against PDE4A	B	8.68	pIC50	2.1	nM	IC50	Bioorg Med Chem Lett (2005) 15: 5241-5246 [PMID:16168647]
phosphodiesterase 4B/Phosphodiesterase 4B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343]
GtoPdb	Inhibition of [3H]-R-rolipram binding to recombinant human PDE4B2 isoenzyme	-	8.07	pKi	8.5	nM	Ki	Cell Biochem Biophys (1998) 29: 113-32 [PMID:9631241]
ChEMBL	Inhibitory activity against PDE4B	B	8.85	pIC50	1.4	nM	IC50	Bioorg Med Chem Lett (2005) 15: 5241-5246 [PMID:16168647]
phosphodiesterase 4C/Phosphodiesterase 4C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL291] [GtoPdb: 1302] [UniProtKB: Q08493]
GtoPdb	Inhibition of [3H]-R-rolipram binding to recombinant human PDE4C2 isoenzyme	-	7.72	pKi	18.9	nM	Ki	Cell Biochem Biophys (1998) 29: 113-32 [PMID:9631241]
ChEMBL	Inhibitory activity against PDE4C	B	8.35	pIC50	4.5	nM	IC50	Bioorg Med Chem Lett (2005) 15: 5241-5246 [PMID:16168647]
phosphodiesterase 4D/Phosphodiesterase 4D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499]
GtoPdb	Inhibition of [3H]-R-rolipram binding to recombinant human PDE4D3 isoenzyme	-	8.15	pKi	7.1	nM	Ki	Cell Biochem Biophys (1998) 29: 113-32 [PMID:9631241]
ChEMBL	Inhibitory activity against PDE4D	B	8.68	pIC50	2.1	nM	IC50	Bioorg Med Chem Lett (2005) 15: 5241-5246 [PMID:16168647]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]