ChEMBL ligand: CHEMBL120077 (JNJ-10198409)
casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 7/Cyclin-dependent kinase 7 in Human [ChEMBL: CHEMBL3055] [GtoPdb: 1979] [UniProtKB: P50613] There should be some charts here, you may need to enable JavaScript!
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] There should be some charts here, you may need to enable JavaScript!
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362] There should be some charts here, you may need to enable JavaScript!
protein tyrosine kinase 2/Focal adhesion kinase 1 in Human [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397] There should be some charts here, you may need to enable JavaScript!
Insulin receptor in Human [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] There should be some charts here, you may need to enable JavaScript!
platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234] There should be some charts here, you may need to enable JavaScript!
platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619] There should be some charts here, you may need to enable JavaScript!
erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626] There should be some charts here, you may need to enable JavaScript!
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] There should be some charts here, you may need to enable JavaScript!
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241] There should be some charts here, you may need to enable JavaScript!
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] There should be some charts here, you may need to enable JavaScript!
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400]
ChEMBL	Inhibitory activity against Casein Kinase 2	B	4	pIC50	>100000	nM	IC50	J Med Chem (2005) 48: 8163-8173 [PMID:16366598]
cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493]
ChEMBL	Inhibitory activity against CDK1	B	4	pIC50	>100000	nM	IC50	J Med Chem (2005) 48: 8163-8173 [PMID:16366598]
ChEMBL	Inhibition of Cdk1	B	5	pIC50	>10000	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
ChEMBL	Inhibitory activity against CDK2	B	5	pIC50	>10000	nM	IC50	J Med Chem (2005) 48: 8163-8173 [PMID:16366598]
ChEMBL	Inhibition of Cdk2	B	5	pIC50	>10000	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802]
ChEMBL	Inhibitory activity against CDK4	B	4	pIC50	>100000	nM	IC50	J Med Chem (2005) 48: 8163-8173 [PMID:16366598]
ChEMBL	Inhibition of Cdk4	B	4	pIC50	>100000	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
cyclin dependent kinase 7/Cyclin-dependent kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3055] [GtoPdb: 1979] [UniProtKB: P50613]
ChEMBL	Inhibitory activity against CDK7	B	4.25	pIC50	56700	nM	IC50	J Med Chem (2005) 48: 8163-8173 [PMID:16366598]
ChEMBL	Inhibition of Cdk7	B	5	pIC50	>10000	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL	Inhibitory activity against EGFR	B	4	pIC50	>100000	nM	IC50	J Med Chem (2005) 48: 8163-8173 [PMID:16366598]
ChEMBL	Inhibition of human EGFR at 10000 nM	B	4	pIC50	>100000	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362]
ChEMBL	Inhibitory activity against bFGFR1	B	4.34	pIC50	45800	nM	IC50	J Med Chem (2005) 48: 8163-8173 [PMID:16366598]
ChEMBL	Inhibition of bFGFR1	B	4.34	pIC50	45800	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
protein tyrosine kinase 2/Focal adhesion kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397]
ChEMBL	Inhibitory activity against FAK	B	4	pIC50	>100000	nM	IC50	J Med Chem (2005) 48: 8163-8173 [PMID:16366598]
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213]
ChEMBL	Inhibitory activity against IRK	B	4	pIC50	>100000	nM	IC50	J Med Chem (2005) 48: 8163-8173 [PMID:16366598]
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
ChEMBL	Inhibitory activity against MAPK	B	4	pIC50	>100000	nM	IC50	J Med Chem (2005) 48: 8163-8173 [PMID:16366598]
platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234]
ChEMBL	Inhibitory activity against PDGFRalpha	B	7.35	pIC50	45	nM	IC50	J Med Chem (2005) 48: 8163-8173 [PMID:16366598]
ChEMBL	Inhibition of PDGFRalpha	B	7.35	pIC50	45	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619]
ChEMBL	Inhibitory activity against PDGFRbeta kinase	B	8.38	pIC50	4.2	nM	IC50	J Med Chem (2005) 48: 8163-8173 [PMID:16366598]
ChEMBL	Inhibition of PDGFRbeta	B	8.38	pIC50	4.2	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
GtoPdb	-	-	8.38	pIC50	4.2	nM	IC50	J Med Chem (2005) 48: 8163-73 [PMID:16366598]
ChEMBL	Antiproliferative activity against PDGF-BB stimulated HCASMC	F	8.52	pIC50	3	nM	IC50	J Med Chem (2005) 48: 8163-8173 [PMID:16366598]
erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626]
ChEMBL	Inhibitory activity against HER2	B	5	pIC50	>10000	nM	IC50	J Med Chem (2005) 48: 8163-8173 [PMID:16366598]
ChEMBL	Inhibition of HER2	B	5	pIC50	>10000	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
ChEMBL	Inhibitory activity against c-ABL	B	7.66	pIC50	22	nM	IC50	J Med Chem (2005) 48: 8163-8173 [PMID:16366598]
ChEMBL	Inhibition of cAbl	B	7.66	pIC50	22	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241]
ChEMBL	Inhibitory activity against FYN	B	6.42	pIC50	378	nM	IC50	J Med Chem (2005) 48: 8163-8173 [PMID:16366598]
ChEMBL	Inhibition of Fyn	B	6.42	pIC50	378	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239]
ChEMBL	Inhibitory activity against LCK	B	7	pIC50	100	nM	IC50	J Med Chem (2005) 48: 8163-8173 [PMID:16366598]
ChEMBL	Inhibition of Lck	B	7	pIC50	100	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
ChEMBL	Inhibitory activity against c-SRC	B	6.73	pIC50	185	nM	IC50	J Med Chem (2005) 48: 8163-8173 [PMID:16366598]
ChEMBL	Inhibition of c-Src	B	6.73	pIC50	185	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]