ChEMBL ligand: CHEMBL2180638 (3-[2-[(Cyclopropylmethyl)(Phenethyl)Amino]Ethyl]Phenol)
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] There should be some charts here, you may need to enable JavaScript!
D1 receptor/Dopamine D1 receptor in Human [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728] There should be some charts here, you may need to enable JavaScript!
D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] There should be some charts here, you may need to enable JavaScript!
D3 receptor/Dopamine D3 receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL	Displacement of [3H]pCl-DPDPE from human delta opioid receptor expressed in CHO cell membranes incubated for 60 mins by liquid scintillation counting	B	5	pKi	>10000	nM	Ki	J Med Chem (2012) 55: 10302-10306 [PMID:23134120]
D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
ChEMBL	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cells	B	5	pKi	>10000	nM	Ki	J Med Chem (2012) 55: 10302-10306 [PMID:23134120]
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL	Displacement of [3H]YM-09151-2 from human dopamine D2 receptor expressed in CHOp cells	B	6.93	pKi	118	nM	Ki	J Med Chem (2012) 55: 10302-10306 [PMID:23134120]
GtoPdb	-	-	6.93	pKi	118	nM	Ki	J Med Chem (2012) 55: 10302-6 [PMID:23134120]
ChEMBL	Agonist activity at human dopamine D2 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assay	F	6.74	pEC50	181	nM	EC50	J Med Chem (2012) 55: 10302-10306 [PMID:23134120]
D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
GtoPdb	-	-	6.77	pKi	168	nM	Ki	J Med Chem (2012) 55: 10302-6 [PMID:23134120]
ChEMBL	Displacement of [3H]YM-09151-2 from human dopamine D3 receptor expressed in CHOp cells	B	6.77	pKi	168	nM	Ki	J Med Chem (2012) 55: 10302-10306 [PMID:23134120]
ChEMBL	Agonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assay	F	7.49	pEC50	32.2	nM	EC50	J Med Chem (2012) 55: 10302-10306 [PMID:23134120]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cell membranes incubated for 60 mins by liquid scintillation counting	B	8.23	pKi	5.9	nM	Ki	J Med Chem (2012) 55: 10302-10306 [PMID:23134120]
GtoPdb	-	-	8.23	pKi	5.9	nM	Ki	J Med Chem (2012) 55: 10302-6 [PMID:23134120]
ChEMBL	Inhibition of kappa opioid receptor (unknown origin) assessed as increase in beta-arrestin 2 recruitment	B	6.35	pEC50	449	nM	EC50	Eur J Med Chem (2019) 183: 111701-111701 [PMID:31550662]
ChEMBL	Inhibition of kappa opioid receptor (unknown origin) by [35S]-GTPgammaS binding assay	F	7.44	pEC50	36.7	nM	EC50	Eur J Med Chem (2019) 183: 111701-111701 [PMID:31550662]
ChEMBL	Agonist activity at human kappa opioid receptor expressed in CHO cell membranes incubated for 60 mins by [35S]GTPgammaS binding assay	F	7.46	pEC50	35	nM	EC50	J Med Chem (2012) 55: 10302-10306 [PMID:23134120]
GtoPdb	Measuring stimulation of [35S]GTPγS binding.	-	7.46	pEC50	35	nM	EC50	J Med Chem (2012) 55: 10302-6 [PMID:23134120]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
GtoPdb	-	-	6.08	pKi	826	nM	Ki	J Med Chem (2012) 55: 10302-6 [PMID:23134120]
ChEMBL	Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cell membranes incubated for 60 mins by liquid scintillation counting	B	6.08	pKi	826	nM	Ki	J Med Chem (2012) 55: 10302-10306 [PMID:23134120]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]