ChEMBL ligand: CHEMBL2180638 (3-[2-[(Cyclopropylmethyl)(Phenethyl)Amino]Ethyl]Phenol)
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] There should be some charts here, you may need to enable JavaScript!
D1 receptor/Dopamine D1 receptor in Human [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728] There should be some charts here, you may need to enable JavaScript!
D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] There should be some charts here, you may need to enable JavaScript!
D3 receptor/Dopamine D3 receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL	Displacement of [3H]pCl-DPDPE from human delta opioid receptor expressed in CHO cell membranes incubated for 60 mins by liquid scintillation counting	B	5	pKi	>10000	nM	Ki	J Med Chem (2012) 55: 10302-10306 [PMID:23134120]
D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
ChEMBL	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cells	B	5	pKi	>10000	nM	Ki	J Med Chem (2012) 55: 10302-10306 [PMID:23134120]
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL	Displacement of [3H]YM-09151-2 from human dopamine D2 receptor expressed in CHOp cells	B	6.93	pKi	118	nM	Ki	J Med Chem (2012) 55: 10302-10306 [PMID:23134120]
GtoPdb	-	-	6.93	pKi	118	nM	Ki	J Med Chem (2012) 55: 10302-6 [PMID:23134120]
ChEMBL	Agonist activity at human dopamine D2 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assay	F	6.74	pEC50	181	nM	EC50	J Med Chem (2012) 55: 10302-10306 [PMID:23134120]
D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
GtoPdb	-	-	6.77	pKi	168	nM	Ki	J Med Chem (2012) 55: 10302-6 [PMID:23134120]
ChEMBL	Displacement of [3H]YM-09151-2 from human dopamine D3 receptor expressed in CHOp cells	B	6.77	pKi	168	nM	Ki	J Med Chem (2012) 55: 10302-10306 [PMID:23134120]
ChEMBL	Agonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assay	F	7.49	pEC50	32.2	nM	EC50	J Med Chem (2012) 55: 10302-10306 [PMID:23134120]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cell membranes incubated for 60 mins by liquid scintillation counting	B	8.23	pKi	5.9	nM	Ki	J Med Chem (2012) 55: 10302-10306 [PMID:23134120]
GtoPdb	-	-	8.23	pKi	5.9	nM	Ki	J Med Chem (2012) 55: 10302-6 [PMID:23134120]
ChEMBL	Inhibition of kappa opioid receptor (unknown origin) assessed as increase in beta-arrestin 2 recruitment	B	6.35	pEC50	449	nM	EC50	Eur J Med Chem (2019) 183: 111701-111701 [PMID:31550662]
ChEMBL	Inhibition of kappa opioid receptor (unknown origin) by [35S]-GTPgammaS binding assay	F	7.44	pEC50	36.7	nM	EC50	Eur J Med Chem (2019) 183: 111701-111701 [PMID:31550662]
ChEMBL	Agonist activity at human kappa opioid receptor expressed in CHO cell membranes incubated for 60 mins by [35S]GTPgammaS binding assay	F	7.46	pEC50	35	nM	EC50	J Med Chem (2012) 55: 10302-10306 [PMID:23134120]
GtoPdb	Measuring stimulation of [35S]GTPγS binding.	-	7.46	pEC50	35	nM	EC50	J Med Chem (2012) 55: 10302-6 [PMID:23134120]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
GtoPdb	-	-	6.08	pKi	826	nM	Ki	J Med Chem (2012) 55: 10302-6 [PMID:23134120]
ChEMBL	Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cell membranes incubated for 60 mins by liquid scintillation counting	B	6.08	pKi	826	nM	Ki	J Med Chem (2012) 55: 10302-10306 [PMID:23134120]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]