JNJ-38431055 [Ligand Id: 5727] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1951032 (Adp-597, Jnj-38431055, JNJ-38431055) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| GPR119/Glucose-dependent insulinotropic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5652] [GtoPdb: 126] [UniProtKB: Q8TDV5] | ||||||||
| GtoPdb | - | - | 7.3 | pEC50 | - | - | - | Bioorg Med Chem Lett (2012) 22: 1750-5 [PMID:22264481] |
| ChEMBL | Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay | F | 7.34 | pEC50 | 46 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 1750-1755 [PMID:22264481] |
| ChEMBL | Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay | F | 7.34 | pEC50 | 46 | nM | EC50 | Bioorg Med Chem Lett (2014) 24: 4332-4335 [PMID:25088191] |
| ChEMBL | Agonist activity at human GPR119 by HTRF cAMP assay | F | 7.34 | pEC50 | 46 | nM | EC50 | Bioorg Med Chem Lett (2015) 25: 3034-3038 [PMID:26048791] |
| GPR119/Glucose-dependent insulinotropic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5262] [GtoPdb: 126] [UniProtKB: Q7TQN8] | ||||||||
| ChEMBL | Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay | F | 6.38 | pEC50 | 421 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 1750-1755 [PMID:22264481] |
| ChEMBL | Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay | F | 6.38 | pEC50 | 421 | nM | EC50 | Bioorg Med Chem Lett (2014) 24: 4332-4335 [PMID:25088191] |
| ChEMBL | Agonist activity at rat GPR119 by HTRF cAMP assay | F | 6.38 | pEC50 | 421 | nM | EC50 | Bioorg Med Chem Lett (2015) 25: 3034-3038 [PMID:26048791] |
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of human ERG by patch clamp assay | B | 4.89 | pIC50 | 13000 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 1750-1755 [PMID:22264481] |
| ChEMBL | Inhibition of human ERG | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 1750-1755 [PMID:22264481] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
