abiraterone acetate [Ligand Id: 9288] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL271227 (Abiraterone acetate, CB7630, CB-7630, NSC-748121, NSC-749227, Yonsa, Zytiga)
  • Androgen receptor/Androgen Receptor in Human [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Androgen receptor/Androgen Receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275]
ChEMBL Antagonist activity at full length human androgen receptor expressed in mammalian expression system measured after 22 to 24 hrs by luciferase reporter gene assay B 4.77 pEC50 17050 nM EC50 Bioorg Med Chem Lett (2017) 27: 2216-2220 [PMID:28385503]
CYP17A1/Cytochrome P450 17A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3522] [GtoPdb: 1361] [UniProtKB: P05093]
ChEMBL Ability to inhibit the Steroid 17-alpha-hydroxylase/17,20 lyase enzyme by 50%. B 7.74 pIC50 18 nM IC50 J. Med. Chem. (1995) 38: 2463-2471 [PMID:7608911]
ChEMBL Ability to inhibit the C17,20-lyase enzyme by 50% using 17-alpha-hydroxyprogesterone as substrate. B 7.77 pIC50 17 nM IC50 J. Med. Chem. (1995) 38: 2463-2471 [PMID:7608911]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]