CYP17A1 | CYP11, CYP17, CYP19, CYP20 and CYP21 families | IUPHAR/BPS Guide to PHARMACOLOGY

Top ▲


Target not currently curated in GtoImmuPdb

Target id: 1361

Nomenclature: CYP17A1

Family: CYP11, CYP17, CYP19, CYP20 and CYP21 families

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 508 10q24.3 CYP17A1 cytochrome P450 family 17 subfamily A member 1
Mouse - 507 19 38.97 cM Cyp17a1 cytochrome P450
Rat - 507 1q55 Cyp17a1 cytochrome P450
Previous and Unofficial Names
Steroid 17-α-hydroxylase/17,20 lyase | cytochrome P450 17A1 | steroid 17-alpha hydroxylase | cytochrome P450, family 17, subfamily a, polypeptide 1 | cytochrome P450, family 17, subfamily A, polypeptide 1 | cytochrome P450
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
Enzyme Reaction
EC Number:
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
abiraterone Hs Inhibition 7.1 – 8.4 pIC50 2-3
pIC50 7.1 – 8.4 [2-3]
galeterone Hs Inhibition 6.5 pIC50 1
pIC50 6.5 (IC50 3x10-7 M) [1]
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0034097 response to cytokine IEP
Clinically-Relevant Mutations and Pathophysiology
Disease:  46,XY disorder of sex development due to isolated 17, 20 lyase deficiency
Synonyms: 46 XY gonadal dysgenesis [Disease Ontology: DOID:14448]
Disease Ontology: DOID:14448
OMIM: 614279
Orphanet: ORPHA90796
Disease:  Congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiency
Synonyms: Congenital adrenal hyperplasia [Disease Ontology: DOID:12255]
Disease Ontology: DOID:12255
OMIM: 202110
Orphanet: ORPHA90793


Show »

1. Handratta VD, Vasaitis TS, Njar VC, Gediya LK, Kataria R, Chopra P, Newman Jr D, Farquhar R, Guo Z, Qiu Y et al.. (2005) Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model. J. Med. Chem., 48 (8): 2972-84. [PMID:15828836]

2. Pinto-Bazurco Mendieta MA, Negri M, Jagusch C, Müller-Vieira U, Lauterbach T, Hartmann RW. (2008) Synthesis, biological evaluation, and molecular modeling of abiraterone analogues: novel CYP17 inhibitors for the treatment of prostate cancer. J. Med. Chem., 51 (16): 5009-18. [PMID:18672868]

3. Potter GA, Barrie SE, Jarman M, Rowlands MG. (1995) Novel steroidal inhibitors of human cytochrome P45017 alpha (17 alpha-hydroxylase-C17,20-lyase): potential agents for the treatment of prostatic cancer. J. Med. Chem., 38 (13): 2463-71. [PMID:7608911]

How to cite this page

Select citation format: