levoketoconazole   Click here for help

GtoPdb Ligand ID: 11829

Synonyms: (2S,4R)-ketoconazole | COR-003 | COR003 | Recorlev®
Approved drug PDB Ligand
levoketoconazole is an approved drug (FDA (2021))
Compound class: Synthetic organic
Comment: Levoketoconazole is the pure (2S,4R) enantiomer of the approved drug ketoconazole. Like ketoconazole, levoketoconazole is orally available. It is a more potent inhibitor of glucocorticoid synthesis than the enantiomerically mixed ketoconazole formulation. Levoketoconazole reduces cortisol biosynthesis by inhibiting three key cytochrome P450 enzymes of the glucocorticoid synthesis pathway; 11β-hydroxylase (CYP11B1), 17α-hydroxylase/17,20-lyase (CYP17A1) and steroid 21-hydroxylase (CYP21A2).
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 8
Topological polar surface area 69.06
Molecular weight 530.15
XLogP 4.08
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES Clc1ccc(c(c1)Cl)[C@@]1(OC[C@H](O1)COc1ccc(cc1)N1CCN(CC1)C(=O)C)Cn1cncc1
Isomeric SMILES CC(=O)N1CCN(CC1)c1ccc(cc1)OC[C@@H]1CO[C@@](O1)(Cn1ccnc1)c1c(cc(cc1)Cl)Cl
InChI InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m1/s1
InChI Key XMAYWYJOQHXEEK-ZEQKJWHPSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (2021))
IUPAC Name Click here for help
1-[4-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone
International Nonproprietary Names Click here for help
INN number INN
10206 levoketoconazole
Synonyms Click here for help
(2S,4R)-ketoconazole | COR-003 | COR003 | Recorlev®
Database Links Click here for help
CAS Registry No. 142128-57-2 (source: WHO INN record)
ChEMBL Ligand CHEMBL295698
DrugBank Ligand DB05667
GtoPdb PubChem SID 461663385
PubChem CID 47576
RCSB PDB Ligand KLN
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UniChem Compound Search for chemical match using the InChIKey XMAYWYJOQHXEEK-ZEQKJWHPSA-N
UniChem Connectivity Search for chemical match using the InChIKey XMAYWYJOQHXEEK-ZEQKJWHPSA-N