mesalazine [Ligand Id: 2700] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL704 (MAX-002, Rowasa, Salofalk, Pentasa sr, Mesalazine, NSC-38877, Delzicol, Mesren mr, Coltec ec, Sfrowasa, Apriso, Mezavant xl, Lialda, Mesalazine, Ipocol, Mesalamine, Canasa, Asacol hd, Pentasa, Asacol, Fisalamine, Octasa)
  • Cyclooxygenase-1 in Sheep [ChEMBL: CHEMBL2949] [UniProtKB: P05979]
  • This target only has 0 pki data point
  • 0
1 CHEMBL704_lig_chart_1 Cyclooxygenase-1 Sheep
There should be some charts here, you may need to enable JavaScript!
  • COX-2 /Cyclooxygenase-2 in Human [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
  • This target only has 0 pki data point
  • 0
2 CHEMBL704_lig_chart_2 Cyclooxygenase-2 Human
There should be some charts here, you may need to enable JavaScript!
  • GroEL/GroES in Escherichia coli [ChEMBL: CHEMBL4106139] [UniProtKB: Q548M1Q7BGE6]
  • This target only has 0 pki data point
  • 0
3 CHEMBL704_lig_chart_3 GroEL/GroES Escherichia coli
There should be some charts here, you may need to enable JavaScript!
4 CHEMBL704_lig_chart_4 HSP60/HSP10 Human
There should be some charts here, you may need to enable JavaScript!
  • Hydroxyacid oxidase 1 in Mouse [ChEMBL: CHEMBL4295985] [UniProtKB: Q9WU19]
  • This target only has 0 pki data point
  • 0
5 CHEMBL704_lig_chart_5 Hydroxyacid oxidase 1 Mouse
There should be some charts here, you may need to enable JavaScript!
  • Neuraminidase in Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus(strain A/WS/1933 H1N1)) [ChEMBL: CHEMBL1287610] [UniProtKB: P03470]
  • This target only has 0 pki data point
  • 0
6 CHEMBL704_lig_chart_6 Neuraminidase Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus(strain A/WS/1933 H1N1))
There should be some charts here, you may need to enable JavaScript!
  • TNF-alpha in Human [ChEMBL: CHEMBL1825] [UniProtKB: P01375]
  • This target only has 0 pki data point
  • 0
7 CHEMBL704_lig_chart_7 TNF-alpha Human
There should be some charts here, you may need to enable JavaScript!
  • Peroxisome proliferator-activated receptor-γ in Human [GtoPdb: 595] [UniProtKB: P37231]
  • This target only has 0 pki data point
  • 0
8 CHEMBL704_lig_chart_8 Peroxisome proliferator-activated receptor-γ Human
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979]
ChEMBL Inhibition of ovine COX1 using arachidonic acid as substrate pretreated for 5 mins followed by substrate addition and measured after 2 mins by fluorescence based enzyme immunoassay B 5.11 pIC50 7730 nM IC50 Eur J Med Chem (2019) 180: 86-98 [PMID:31301566]
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
ChEMBL Inhibition of recombinant human COX2 using arachidonic acid as substrate pretreated for 5 mins followed by substrate addition and measured after 2 mins by fluorescence based enzyme immunoassay B 5.12 pIC50 7530 nM IC50 Eur J Med Chem (2019) 180: 86-98 [PMID:31301566]
GroEL/GroES in Escherichia coli (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4106139] [UniProtKB: Q548M1Q7BGE6]
ChEMBL Inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured soluble pig heart MDH refolding by measuring MDH enzyme activity using sodium mesoxalate as substrate after 20 to 40 mins by malachite green dye based spectrometric analysis B 5.22 pIC50 6000 nM IC50 Bioorg Med Chem Lett (2019) 29: 1106-1112 [PMID:30852084]
ChEMBL Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured rhodanese refolding by measuring rhodanese enzyme activity after 45 mins by Fe(SCN)3 dye based spectrometric analysis B 6.31 pIC50 490 nM IC50 Bioorg Med Chem Lett (2019) 29: 1106-1112 [PMID:30852084]
HSP60/HSP10 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4106131] [UniProtKB: P10809P61604]
ChEMBL Inhibition of human N-terminal octa-His-tagged HSP60 expressed in Escherichia coli Rosetta(DE3) pLysS/human HSP10 expressed in Escherichia coli Rosetta(DE3) assessed as reduction in HSP60/HSP10-mediated denatured MDH refolding by measuring MDH enzyme activity using sodium mesoxalate as substrate after 40 to 60 mins by malachite green dye based spectrometric analysis B 4.92 pIC50 12000 nM IC50 Bioorg Med Chem Lett (2019) 29: 1106-1112 [PMID:30852084]
Hydroxyacid oxidase 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295985] [UniProtKB: Q9WU19]
ChEMBL Inhibition of mouse recombinant glycolate oxidase expressed in Escherichia coli using glycolate as substrate by sulfonated DCIP dye-based assay B 5.11 pIC50 7800 nM IC50 J Med Chem (2018) 61: 7144-7167 [PMID:30028141]
Neuraminidase in Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus(strain A/WS/1933 H1N1)) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1287610] [UniProtKB: P03470]
ChEMBL Inhibition of Influenza A virus A/WSN/1933(H1N1)) neuraminidase in the presence of 2'-(4-methyl-umbelliferyl)-alphaD-N-acetylneuraminic acid substrate after 10 mins by fluorometric assay B 4 pIC50 >100000 nM IC50 J. Med. Chem. (2012) 55: 8493-8501 [PMID:22963087]
TNF-alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1825] [UniProtKB: P01375]
ChEMBL Inhibition of TNFalpha (unknown origin)-induced adhesion of BCECF fluorescence-labeled human U937 cells to human HT-29 cells pretreated for 1 hr followed by BCECF fluorescence-labeled human U937 cell/TNFalpha addition and measured after 3 hrs by fluorescence assay B 4.7 pIC50 20000 nM IC50 MedChemComm (2018) 9: 1305-1310
Peroxisome proliferator-activated receptor-γ in Human [GtoPdb: 595] [UniProtKB: P37231]
GtoPdb - - 1.82 pIC50 - - - J Exp Med (2005) 201: 1205-15 [PMID:15824083]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]