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Synonyms: arginine-rich, mutated in early stage tumors-like 1 | ARMETL1
Compound class:
Endogenous peptide in human, mouse or rat
Comment: CDNF is a dopamine neuron neurotropic factor [5]. It provides cytoprotective effects in neurodegenerative disease models by reducing the activating effect of endoplasmic reticulum stress on the unfolded protein response (UPR) pathway [4,7]. Specifically, CDNF has been shown to protect dopamine neurons and improve motor function in animal Parkinson's disease models [1-2,5-6,8]. However therapeutic use of proteins like CDNF is invasive (intracranial administration) and requires clinical expertise.
Species: Human
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Classification  |
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| Compound class | Endogenous peptide in human, mouse or rat |
| Synonyms |
| arginine-rich, mutated in early stage tumors-like 1 | ARMETL1 |
| Gene/Precursor |
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| Database Links |
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| Ensembl Gene | ENSG00000185267 (Hs) |
| Entrez Gene | 441549 (Hs) |
| GtoPdb PubChem SID | 491299830 |
| Human Protein Atlas | ENSG00000185267 (Hs) |
| OMIM | 611233 (Hs) |
| RefSeq Protein | NP_001025125 (Hs) |
| UniProtKB | Q49AH0 (Hs) |
