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Synonyms: arginine-rich, mutated in early stage tumors-like 1 | ARMETL1
Compound class:
Endogenous peptide in human, mouse or rat
Comment: CDNF is a dopamine neuron neurotropic factor [5]. It provides cytoprotective effects in neurodegenerative disease models by reducing the activating effect of endoplasmic reticulum stress on the unfolded protein response (UPR) pathway [4,7]. Specifically, CDNF has been shown to protect dopamine neurons and improve motor function in animal Parkinson's disease models [1-2,5-6,8]. However therapeutic use of proteins like CDNF is invasive (intracranial administration) and requires clinical expertise.
Species: Human
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| Bioactivity Comments |
| A domain within the C-terminal domain of CDNF interacts with heat shock protein family A (Hsp70) member 5 (HSPA5; GRP78). CDNF/HSPA5 complexes interact with proteins (IRE1, PERK, and ATF6) that activate unfolded protein response (UPR) pathways. |
| Selectivity at other protein targets | ||||||||||||||||||||||||||||||||||
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