cetocycline   Click here for help

GtoPdb Ligand ID: 10792

Synonyms: A-40728 | Abbott 40728 | chelocardin | compound 1 [PMID: 379332]
Compound class: Synthetic organic
Comment: Cetocycline is an atypical tetracycline type antibacterial [2-3]. It is effective against tetracycline resistant bacteria suggesting that its mechanism of action is different to that of tetracycline [4].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 6
Hydrogen bond donors 5
Rotatable bonds 1
Topological polar surface area 158.15
Molecular weight 411.13
XLogP 2.15
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CC(=O)C1=C(O)[C@@]2([C@H]([C@H](C1=O)N)Cc1c(C2=O)c(O)c2c(c1C)ccc(c2O)C)O
Isomeric SMILES CC(=O)C1=C(O)[C@@]2([C@H]([C@H](C1=O)N)Cc1c(C2=O)c(O)c2c(c1C)ccc(c2O)C)O
InChI InChI=1S/C22H21NO7/c1-7-4-5-10-8(2)11-6-12-16(23)19(27)13(9(3)24)20(28)22(12,30)21(29)15(11)18(26)14(10)17(7)25/h4-5,12,16,25-26,28,30H,6,23H2,1-3H3/t12-,16+,22+/m0/s1
InChI Key LUYXWZOOMKBUMB-ONJZCGHCSA-N
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
(1R,4aR,12aS)-3-acetyl-1-amino-4,4a,6,7-tetrahydroxy-8,11-dimethyl-12,12a-dihydro-1H-tetracene-2,5-dione
International Nonproprietary Names Click here for help
INN number INN
3919 cetocycline
Synonyms Click here for help
A-40728 | Abbott 40728 | chelocardin | compound 1 [PMID: 379332]
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Cetocycline (Chelocardin/Cetotetrin)
Other databases
CAS Registry No. 29144-42-1 (source: WHO INN record)
ChEMBL Ligand CHEMBL2110884
GtoPdb PubChem SID 405560233
PubChem CID 71402
Search Google for chemical match using the InChIKey LUYXWZOOMKBUMB-ONJZCGHCSA-N
Search Google for chemicals with the same backbone LUYXWZOOMKBUMB
Search PubMed clinical trials cetocycline
Search PubMed titles cetocycline
Search PubMed titles/abstracts cetocycline
UniChem Compound Search for chemical match using the InChIKey LUYXWZOOMKBUMB-ONJZCGHCSA-N
UniChem Connectivity Search for chemical match using the InChIKey LUYXWZOOMKBUMB-ONJZCGHCSA-N