ChEMBL ligand: CHEMBL506247 (Asian holly oak nutgall, E181, FEMA NO. 3042, Gallotannic acid, Gallotannin, NSC-656273, NSC-758670, Tannic acid, Tannic acid component of depinar, Tannic acid component of oc-108, Tannic acid, unspecified, Tannicum acidum)
hydroxymethylglutaryl-CoA reductase/3-hydroxy-3-methylglutaryl-coenzyme A reductase in Human [ChEMBL: CHEMBL402] [GtoPdb: 639] [UniProtKB: P04035] There should be some charts here, you may need to enable JavaScript!
aldo-keto reductase family 1 member B/Aldo-keto reductase family 1 member B1 in Rat [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase in Dicentrarchus labrax [ChEMBL: CHEMBL1795125] [UniProtKB: Q2PCB5] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 1/Carbonic anhydrase 1 in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 2/Carbonic anhydrase 2 in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase 6 in Human [ChEMBL: CHEMBL3025] [UniProtKB: P23280] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 5A/cGMP-specific 3`,5`-cyclic phosphodiesterase in Human [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074] There should be some charts here, you may need to enable JavaScript!
CYP1A2/Cytochrome P450 1A2 in Human [ChEMBL: CHEMBL3356] [GtoPdb: 1319] [UniProtKB: P05177] There should be some charts here, you may need to enable JavaScript!
CYP2C9/Cytochrome P450 2C9 in Human [ChEMBL: CHEMBL3397] [GtoPdb: 1326] [UniProtKB: P11712] There should be some charts here, you may need to enable JavaScript!
Genome polyprotein in dengue virus type 2 [ChEMBL: CHEMBL5980] [UniProtKB: P29990] There should be some charts here, you may need to enable JavaScript!
GroEL/GroES in Escherichia coli [ChEMBL: CHEMBL4106139] [UniProtKB: Q548M1, Q7BGE6] There should be some charts here, you may need to enable JavaScript!
HSP60/HSP10 in Human [ChEMBL: CHEMBL4106131] [UniProtKB: P10809, P61604] There should be some charts here, you may need to enable JavaScript!
Leukotriene C4 synthase in Guinea pig [ChEMBL: CHEMBL1909043] [UniProtKB: A6XA80] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 1/Mitogen-activated protein kinase 1 in Human [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 14/Mitogen-activated protein kinase 14 in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 3/Mitogen-activated protein kinase 3 in Human [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361] There should be some charts here, you may need to enable JavaScript!
Polyunsaturated fatty acid lipoxygenase ALOX15 in Rabbit [ChEMBL: CHEMBL4358] [UniProtKB: P12530] There should be some charts here, you may need to enable JavaScript!
CoV 3C-like (main) protease/CoV Replicase polyprotein 1a/Replicase polyprotein 1a in Severe acute respiratory syndrome-related coronavirus [ChEMBL: CHEMBL3927] [GtoPdb: 3111, 3124] [UniProtKB: P0C6U8] There should be some charts here, you may need to enable JavaScript!
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1] There should be some charts here, you may need to enable JavaScript!
CYP5A1/Thromboxane-A synthase in Human [ChEMBL: CHEMBL1835] [GtoPdb: 1353] [UniProtKB: P24557] There should be some charts here, you may need to enable JavaScript!
transmembrane serine protease 2/Transmembrane protease serine 2 in Human [ChEMBL: CHEMBL1795140] [GtoPdb: 2421] [UniProtKB: O15393] There should be some charts here, you may need to enable JavaScript!
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Fyn in Human [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241] There should be some charts here, you may need to enable JavaScript!
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lck in Human [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
hydroxymethylglutaryl-CoA reductase/3-hydroxy-3-methylglutaryl-coenzyme A reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL402] [GtoPdb: 639] [UniProtKB: P04035]
ChEMBL	DRUGMATRIX: HMG-CoA Reductase enzyme inhibition (substrate: [14C]HMG-CoA)	B	5.5	pIC50	3127	nM	IC50	DrugMatrix in vitro pharmacology data
aldo-keto reductase family 1 member B/Aldo-keto reductase family 1 member B1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943]
ChEMBL	DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde)	B	6.46	pIC50	346	nM	IC50	DrugMatrix in vitro pharmacology data
Carbonic anhydrase in Dicentrarchus labrax (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795125] [UniProtKB: Q2PCB5]
ChEMBL	Inhibition of Dicentrarchus labrax CA using 4-nitrophenylacetate substrate by esterase assay	B	5.03	pKi	9410	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4259-4262 [PMID:21669522]
carbonic anhydrase 1/Carbonic anhydrase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
ChEMBL	Inhibition of human CA1 using 4-nitrophenylacetate substrate by esterase assay	B	4.12	pKi	75900	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4259-4262 [PMID:21669522]
carbonic anhydrase 2/Carbonic anhydrase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL	Inhibition of human CA2 using 4-nitrophenylacetate substrate by esterase assay	B	4.48	pKi	32800	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4259-4262 [PMID:21669522]
Carbonic anhydrase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280]
ChEMBL	Inhibition of human CA6 using 4-nitrophenylacetate substrate by esterase assay	B	4.75	pKi	17800	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4259-4262 [PMID:21669522]
phosphodiesterase 5A/cGMP-specific 3`,5`-cyclic phosphodiesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074]
ChEMBL	DRUGMATRIX: Phosphodiesterase PDE5 enzyme inhibition (substrate: [3H]cGMP + cGMP)	B	5.33	pIC50	4703	nM	IC50	DrugMatrix in vitro pharmacology data
CYP1A2/Cytochrome P450 1A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3356] [GtoPdb: 1319] [UniProtKB: P05177]
ChEMBL	DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)	B	6.04	pIC50	919	nM	IC50	DrugMatrix in vitro pharmacology data
CYP2C9/Cytochrome P450 2C9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3397] [GtoPdb: 1326] [UniProtKB: P11712]
ChEMBL	DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)	B	5.34	pIC50	4607.4	nM	IC50	DrugMatrix in vitro pharmacology data
Genome polyprotein in dengue virus type 2 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5980] [UniProtKB: P29990]
ChEMBL	Inhibition of Dengue Virus 1 recombinant NS2B-NS3 protease expressed in Escherichia coli using Bz-Nle-Arg-Arg-AMC as substrate incubated for 30 mins	B	6.89	pIC50	130	nM	IC50	Bioorg Med Chem (2021) 49: 116415-116415 [PMID:34601454]
ChEMBL	Inhibition of Dengue Virus 2 recombinant NS2B-NS3 protease expressed in Escherichia coli using Bz-Nle-Arg-Arg-AMC as substrate incubated for 30 mins	B	6.89	pIC50	130	nM	IC50	Bioorg Med Chem (2021) 49: 116415-116415 [PMID:34601454]
ChEMBL	Inhibition of Dengue Virus 3 recombinant NS2B-NS3 protease expressed in Escherichia coli using Bz-Nle-Arg-Arg-AMC as substrate incubated for 30 mins	B	6.89	pIC50	130	nM	IC50	Bioorg Med Chem (2021) 49: 116415-116415 [PMID:34601454]
ChEMBL	Inhibition of Dengue Virus 4 recombinant NS2B-NS3 protease expressed in Escherichia coli using Bz-Nle-Arg-Arg-AMC as substrate incubated for 30 mins	B	6.89	pIC50	130	nM	IC50	Bioorg Med Chem (2021) 49: 116415-116415 [PMID:34601454]
GroEL/GroES in Escherichia coli (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4106139] [UniProtKB: Q548M1, Q7BGE6]
ChEMBL	Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured rhodanese refolding by measuring rhodanese enzyme activity after 45 mins by Fe(SCN)3 dye based spectrometric analysis	B	6	pIC50	1000	nM	IC50	Bioorg Med Chem Lett (2019) 29: 1106-1112 [PMID:30852084]
ChEMBL	Inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured soluble pig heart MDH refolding by measuring MDH enzyme activity using sodium mesoxalate as substrate after 20 to 40 mins by malachite green dye based spectrometric analysis	B	6.06	pIC50	870	nM	IC50	Bioorg Med Chem Lett (2019) 29: 1106-1112 [PMID:30852084]
HSP60/HSP10 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4106131] [UniProtKB: P10809, P61604]
ChEMBL	Inhibition of human N-terminal octa-His-tagged HSP60 expressed in Escherichia coli Rosetta(DE3) pLysS/human HSP10 expressed in Escherichia coli Rosetta(DE3) assessed as reduction in HSP60/HSP10-mediated denatured MDH refolding by measuring MDH enzyme activity using sodium mesoxalate as substrate after 40 to 60 mins by malachite green dye based spectrometric analysis	B	5.42	pIC50	3800	nM	IC50	Bioorg Med Chem Lett (2019) 29: 1106-1112 [PMID:30852084]
Leukotriene C4 synthase in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1909043] [UniProtKB: A6XA80]
ChEMBL	DRUGMATRIX: Leukotriene LTC4 Synthase enzyme inhibition (substrate: LTA4)	B	5.57	pIC50	2715	nM	IC50	DrugMatrix in vitro pharmacology data
mitogen-activated protein kinase 1/Mitogen-activated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
ChEMBL	DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein)	B	6.73	pIC50	185	nM	IC50	DrugMatrix in vitro pharmacology data
mitogen-activated protein kinase 14/Mitogen-activated protein kinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
ChEMBL	DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein)	B	6.43	pIC50	375	nM	IC50	DrugMatrix in vitro pharmacology data
mitogen-activated protein kinase 3/Mitogen-activated protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361]
ChEMBL	DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein)	B	5.39	pIC50	4052	nM	IC50	DrugMatrix in vitro pharmacology data
Polyunsaturated fatty acid lipoxygenase ALOX15 in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4358] [UniProtKB: P12530]
ChEMBL	DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid)	B	6.57	pIC50	268	nM	IC50	DrugMatrix in vitro pharmacology data
CoV 3C-like (main) protease/CoV Replicase polyprotein 1a/Replicase polyprotein 1a in Severe acute respiratory syndrome-related coronavirus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3927] [GtoPdb: 3111, 3124] [UniProtKB: P0C6U8]
ChEMBL	Inhibition of SARS-CoV 3CLpro	B	5.08	pEC50	8307	nM	EC50	Eur J Med Chem (2023) 257: 115503-115503 [PMID:37229831]
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1]
ChEMBL	Inhibition of recombinant SARS-CoV-2 Main protease by FRET analysis	B	4.88	pIC50	13200	nM	IC50	J Med Chem (2024) 67: 11522-11542 [PMID:38967785]
ChEMBL	Inhibition of N-terminal His6-tagged recombinant full length SARS-CoV-2 3CLpro expressed in Escherichia coli BL21(DE3) using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as fluorogenic substrate preincubated with compound for 10 mins followed by substrate addition by FRET assay	B	6.23	pEC50	585	nM	EC50	Eur J Med Chem (2023) 257: 115503-115503 [PMID:37229831]
CYP5A1/Thromboxane-A synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1835] [GtoPdb: 1353] [UniProtKB: P24557]
ChEMBL	DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2)	B	6.49	pIC50	325	nM	IC50	DrugMatrix in vitro pharmacology data
transmembrane serine protease 2/Transmembrane protease serine 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795140] [GtoPdb: 2421] [UniProtKB: O15393]
ChEMBL	Inhibition of human recombinant TMPRSS2 using Boc-Gln-Ala-Arg-AMC as peptide substrate pre-incubated with compound for 30 mins followed by substrate addition by fluorescence based assay	B	5.64	pIC50	2310	nM	IC50	J Med Chem (2024) 67: 11522-11542 [PMID:38967785]
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Fyn in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241]
ChEMBL	DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr))	B	7.66	pIC50	22	nM	IC50	DrugMatrix in vitro pharmacology data
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lck in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239]
ChEMBL	DRUGMATRIX: Protein Tyrosine Kinase, LCK enzyme inhibition (substrate: Poly(Glu:Tyr))	B	7.1	pIC50	79	nM	IC50	DrugMatrix in vitro pharmacology data

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]