compound 32 [PMID: 31638797] [Ligand Id: 10528] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| RAR-related orphan receptor-γ in Human [GtoPdb: 600] [UniProtKB: P51449] | ||||||||
| GtoPdb | Determined in a competition binding scintillation proximity assay (SPA), using recombinant His-tagged RORγ ligand binding domain (A262-S507) and [3H] 25-hydroxycholesterol as tracer. | - | 10.44 | pIC50 | 0.04 | nM | IC50 | WO2016179460A1. Tricyclic sulfones as rorĪ modulators (2016) |
| GtoPdb | Determined in a luciferase reporter assay; measuring inhibition of constitutive activity of RORγt in Jurkat cells overexpressing full length RORγt proteins fused with the Gal4 Luc reporter. | - | 7.62 | pEC50 | 24 | nM | EC50 | J Med Chem (2019) 62: 9931-9946 [PMID:31638797] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
