tolmetin [Ligand Id: 7311] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1020 (MCN-2559, Tolectin, Tolmetin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| aldo-keto reductase family 1 member B/Aldose reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121] | ||||||||
| ChEMBL | Inhibition of Homo sapiens (human) aldose reductase | B | 5.62 | pIC50 | 2390 | nM | IC50 | Med Chem Res (2013) 22: 3589-3605 |
| aldo-keto reductase family 1 member B/Aldose reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943] | ||||||||
| ChEMBL | DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) | B | 5.67 | pIC50 | 2153 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] | ||||||||
| ChEMBL | DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) | B | 7.39 | pIC50 | 41 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| Glyoxalase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2424] [UniProtKB: Q04760] | ||||||||
| ChEMBL | Inhibition of glyoxalase 1 | B | 4.06 | pKi | 87800 | nM | Ki | Bioorg Med Chem (2011) 19: 1189-1196 [PMID:21237663] |
| ChEMBL | Inhibition of human glyoxalase 1 | B | 4.06 | pKi | 87800 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 4243-4247 [PMID:21689932] |
| Interleukin-8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2157] [UniProtKB: P10145] | ||||||||
| ChEMBL | Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay | B | 7.05 | pIC50 | 90 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 4026-4030 [PMID:19560921] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
