BNTX [Ligand Id: 1634] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL101519 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] | ||||||||
| GtoPdb | - | - | 8.4 | pKi | - | - | - | NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407] |
| ChEMBL | Binding affinity was determined in a crude membrane preparation from guinea pig brain by displacement of [3H]DPDPE from Opioid receptor delta 1 | B | 8.43 | pKi | 3.7 | nM | Ki | J Med Chem (1997) 40: 749-753 [PMID:9057861] |
| ChEMBL | Tested for binding activity against Opioid receptor delta 2 using [3H]DSLET ligand | B | 8.74 | pKi | 1.8 | nM | Ki | J Med Chem (1994) 37: 579-585 [PMID:8126697] |
| δ receptor in Mouse [GtoPdb: 317] [UniProtKB: P32300] | ||||||||
| GtoPdb | - | - | 9.2 | pKi | - | - | - | Mol Pharmacol (1994) 45: 330-4 [PMID:8114680] |
| δ receptor/Delta opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533] | ||||||||
| ChEMBL | Binding affinity evaluated by inhibition of binding of [3H]DADLE to delta opioid receptor of rat brain | B | 8.43 | pKi | 3.7 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 357-362 [PMID:10091684] |
| GtoPdb | - | - | 8.7 | pKi | - | - | - | Br J Pharmacol (1999) 128: 556-62 [PMID:10516632] |
| ChEMBL | Tested for binding activity against Opioid receptor delta 1 using [3H]DPDPE ligand | B | 9.08 | pKi | 0.83 | nM | Ki | J Med Chem (1994) 37: 579-585 [PMID:8126697] |
| Kappa opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3952] [UniProtKB: P41144] | ||||||||
| ChEMBL | Tested for binding activity against kappa opioid receptor using [3H]U-69593 ligand | B | 7.18 | pKi | 66 | nM | Ki | J Med Chem (1994) 37: 579-585 [PMID:8126697] |
| ChEMBL | Binding affinity was determined in a crude membrane preparation from guinea pig brain by displacement of [3H]U-69593 from Opioid receptor kappa 1 | B | 7.47 | pKi | 34 | nM | Ki | J Med Chem (1997) 40: 749-753 [PMID:9057861] |
| μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
| ChEMBL | Tested for binding activity against mu opioid receptor using [3H]DAMGO ligand | B | 8.72 | pKi | 1.9 | nM | Ki | J Med Chem (1994) 37: 579-585 [PMID:8126697] |
| GtoPdb | - | - | 8.8 | pKi | - | - | - | NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407] |
| Mu opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4354] [UniProtKB: P97266] | ||||||||
| ChEMBL | Binding affinity was determined in a crude membrane preparation from guinea pig brain by displacement of [3H]DAMGO from Opioid receptor mu 1 | B | 7.48 | pKi | 33 | nM | Ki | J Med Chem (1997) 40: 749-753 [PMID:9057861] |
| κ receptor in Human [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
| GtoPdb | - | - | 8.4 | pKi | - | - | - | NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
