pentostatin [Ligand Id: 4805] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1580 (CI-825, Deoxycoformycin, Nipent, NSC-218321, PD 81565, PD-81565, Pentostatin, YK-176)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Adenosine deaminase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523370] [UniProtKB: Q86GS5]
ChEMBL Inhibition of Plasmodium falciparum N-terminal thrombin cleavable His6-tagged ADA expressed in Escherichia coli BL21 assessed as reduction in formation of inosine using adenosine as substrate B 8.09 pKi 8.2 nM Ki J Med Chem (2019) 62: 8365-8391 [PMID:30964283]
ChEMBL Inhibition of Plasmodium falciparum N-terminal thrombin cleavable His6-tagged ADA expressed in Escherichia coli BL21 assessed as equilibrium dissociation constant by measuring reduction in formation of inosine using adenosine as substrate B 10.42 pKi 0.04 nM Ki J Med Chem (2019) 62: 8365-8391 [PMID:30964283]
Adenosine deaminase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1910] [GtoPdb: 1230] [UniProtKB: P00813]
ChEMBL Inhibition of human erythrocytes ADA assessed as reduction in formation of inosine using adenosine as substrate B 9.3 pKi 0.5 nM Ki J Med Chem (2019) 62: 8365-8391 [PMID:30964283]
ChEMBL Compound was evaluated for the inhibition of adenosine deaminase B 10 pKi 0.1 nM Ki J Med Chem (1981) 24: 1383-1385 [PMID:7310814]
ChEMBL Inhibition constant against human adenosine deaminase was determined B 10.48 pKi 0.03 nM Ki Bioorg Med Chem Lett (2003) 13: 1115-1118 [PMID:12643924]
ChEMBL Inhibition of human erythrocytes ADA assessed as equilibrium dissociation constant by measuring reduction in formation of inosine using adenosine as substrate B 10.59 pKi 0.03 nM Ki J Med Chem (2019) 62: 8365-8391 [PMID:30964283]
GtoPdb - - 10.8 pIC50 - - - Biochem Pharmacol (1977) 26: 359-67 [PMID:849330]
Adenosine deaminase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2966] [UniProtKB: P56658]
ChEMBL Binding affinity against Adenosine deaminase from calf intestinal mucosa was determined B 11 pKi 0.01 nM Ki Bioorg Med Chem Lett (2001) 11: 2893-2896 [PMID:11677121]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]