pentostatin [Ligand Id: 4805] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1580 (PD-81565, Pentostatin, PD 81565, CI-825, YK-176, Nipent, NSC-218321)
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Adenosine deaminase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523370] [UniProtKB: Q86GS5]
ChEMBL Inhibition of Plasmodium falciparum N-terminal thrombin cleavable His6-tagged ADA expressed in Escherichia coli BL21 assessed as reduction in formation of inosine using adenosine as substrate B 8.09 pKi 8.2 nM Ki J Med Chem (2019) 62: 8365-8391 [PMID:30964283]
ChEMBL Inhibition of Plasmodium falciparum N-terminal thrombin cleavable His6-tagged ADA expressed in Escherichia coli BL21 assessed as equilibrium dissociation constant by measuring reduction in formation of inosine using adenosine as substrate B 10.42 pKi 0.04 nM Ki J Med Chem (2019) 62: 8365-8391 [PMID:30964283]
Adenosine deaminase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1910] [GtoPdb: 1230] [UniProtKB: P00813]
ChEMBL Inhibition of human erythrocytes ADA assessed as reduction in formation of inosine using adenosine as substrate B 9.3 pKi 0.5 nM Ki J Med Chem (2019) 62: 8365-8391 [PMID:30964283]
ChEMBL Compound was evaluated for the inhibition of adenosine deaminase B 10 pKi 0.1 nM Ki J. Med. Chem. (1981) 24: 1383-1385 [PMID:7310814]
ChEMBL Inhibition constant against human adenosine deaminase was determined B 10.48 pKi 0.03 nM Ki Bioorg. Med. Chem. Lett. (2003) 13: 1115-1118 [PMID:12643924]
ChEMBL Inhibition of human erythrocytes ADA assessed as equilibrium dissociation constant by measuring reduction in formation of inosine using adenosine as substrate B 10.59 pKi 0.03 nM Ki J Med Chem (2019) 62: 8365-8391 [PMID:30964283]
GtoPdb - - 10.8 pIC50 - - - Biochem Pharmacol (1977) 26: 359-67 [PMID:849330]
Adenosine deaminase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2966] [UniProtKB: P56658]
ChEMBL Binding affinity against Adenosine deaminase from calf intestinal mucosa was determined B 11 pKi 0.01 nM Ki Bioorg. Med. Chem. Lett. (2001) 11: 2893-2896 [PMID:11677121]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]