Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL1580 (CI-825, Deoxycoformycin, Nipent, NSC-218321, PD 81565, PD-81565, Pentostatin, YK-176) |
---|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
Adenosine deaminase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523370] [UniProtKB: Q86GS5] | ||||||||
ChEMBL | Inhibition of Plasmodium falciparum N-terminal thrombin cleavable His6-tagged ADA expressed in Escherichia coli BL21 assessed as reduction in formation of inosine using adenosine as substrate | B | 8.09 | pKi | 8.2 | nM | Ki | J Med Chem (2019) 62: 8365-8391 [PMID:30964283] |
ChEMBL | Inhibition of Plasmodium falciparum N-terminal thrombin cleavable His6-tagged ADA expressed in Escherichia coli BL21 assessed as equilibrium dissociation constant by measuring reduction in formation of inosine using adenosine as substrate | B | 10.42 | pKi | 0.04 | nM | Ki | J Med Chem (2019) 62: 8365-8391 [PMID:30964283] |
Adenosine deaminase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1910] [GtoPdb: 1230] [UniProtKB: P00813] | ||||||||
ChEMBL | Inhibition of human erythrocytes ADA assessed as reduction in formation of inosine using adenosine as substrate | B | 9.3 | pKi | 0.5 | nM | Ki | J Med Chem (2019) 62: 8365-8391 [PMID:30964283] |
ChEMBL | Compound was evaluated for the inhibition of adenosine deaminase | B | 10 | pKi | 0.1 | nM | Ki | J Med Chem (1981) 24: 1383-1385 [PMID:7310814] |
ChEMBL | Inhibition constant against human adenosine deaminase was determined | B | 10.48 | pKi | 0.03 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 1115-1118 [PMID:12643924] |
ChEMBL | Inhibition of human erythrocytes ADA assessed as equilibrium dissociation constant by measuring reduction in formation of inosine using adenosine as substrate | B | 10.59 | pKi | 0.03 | nM | Ki | J Med Chem (2019) 62: 8365-8391 [PMID:30964283] |
GtoPdb | - | - | 10.8 | pIC50 | - | - | - | Biochem Pharmacol (1977) 26: 359-67 [PMID:849330] |
Adenosine deaminase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2966] [UniProtKB: P56658] | ||||||||
ChEMBL | Binding affinity against Adenosine deaminase from calf intestinal mucosa was determined | B | 11 | pKi | 0.01 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 2893-2896 [PMID:11677121] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]