ChEMBL ligand: CHEMBL3188597
lysine demethylase 3A/Lysine-specific demethylase 3A in Human [ChEMBL: CHEMBL1938209] [GtoPdb: 2673] [UniProtKB: Q9Y4C1] There should be some charts here, you may need to enable JavaScript!
lysine demethylase 4E/Lysine-specific demethylase 4D-like in Human [ChEMBL: CHEMBL1293226] [GtoPdb: 2679] [UniProtKB: B2RXH2] There should be some charts here, you may need to enable JavaScript!
lysine demethylase 5A/Lysine-specific demethylase 5A in Human [ChEMBL: CHEMBL2424504] [GtoPdb: 2680] [UniProtKB: P29375] There should be some charts here, you may need to enable JavaScript!
lysine demethylase 6A/Lysine-specific demethylase 6A in Human [ChEMBL: CHEMBL2069164] [GtoPdb: 2684] [UniProtKB: O15550] There should be some charts here, you may need to enable JavaScript!
lysine demethylase 6B/Lysine-specific demethylase 6B in Human [ChEMBL: CHEMBL1938211] [GtoPdb: 2685] [UniProtKB: O15054] There should be some charts here, you may need to enable JavaScript!
Prolyl 4-hydroxylase in Paramecium bursaria Chlorella virus 1 [ChEMBL: CHEMBL4523368] [UniProtKB: Q84406] There should be some charts here, you may need to enable JavaScript!
lysine demethylase 5B in Human [GtoPdb: 2681] [UniProtKB: Q9UGL1] There should be some charts here, you may need to enable JavaScript!
lysine demethylase 5C in Human [GtoPdb: 2682] [UniProtKB: P41229] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
lysine demethylase 3A/Lysine-specific demethylase 3A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1938209] [GtoPdb: 2673] [UniProtKB: Q9Y4C1]
ChEMBL	Inhibition of KDM3A (unknown origin)	B	4.4	pIC50	39810.72	nM	IC50	Medchemcomm (2014) 5: 1879-1886 [PMID:26682034]
lysine demethylase 4E/Lysine-specific demethylase 4D-like in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293226] [GtoPdb: 2679] [UniProtKB: B2RXH2]
ChEMBL	Inhibition of KDM4E (unknown origin)	B	4.7	pIC50	19952.62	nM	IC50	Medchemcomm (2014) 5: 1879-1886 [PMID:26682034]
lysine demethylase 5A/Lysine-specific demethylase 5A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2424504] [GtoPdb: 2680] [UniProtKB: P29375]
ChEMBL	Binding affinity to KDM5A ARID/PhD1 domain deletion mutant (1 to 588 residues) (unknown origin) by ITC assay	B	4.92	pKd	12000	nM	Kd	J Med Chem (2018) 61: 10588-10601 [PMID:30392349]
GtoPdb	-	-	5.17	pIC50	6800	nM	IC50	Nature (2014) 514: E1-2 [PMID:25279926]
lysine demethylase 6A/Lysine-specific demethylase 6A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069164] [GtoPdb: 2684] [UniProtKB: O15550]
ChEMBL	Inhibition of KDM6A (880 to 1401 residues) (unknown origin) using H3 ( 21 to 44 residues) K27me3 as substrate preincubated for 15 min followed by substrate addition measured after 15 mins by FDH-coupled demethylase assay	B	4.16	pIC50	69000	nM	IC50	J Med Chem (2018) 61: 10588-10601 [PMID:30392349]
GtoPdb	-	-	7.28	pIC50	53	nM	IC50	Nature (2014) 514: E1-2 [PMID:25279926]
lysine demethylase 6B/Lysine-specific demethylase 6B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1938211] [GtoPdb: 2685] [UniProtKB: O15054]
ChEMBL	Inhibition of JMJD3 (unknown origin) using biotinylated H3K27me3 peptide as substrate after 1 hr by AlphaLISA assay	B	6.82	pIC50	150	nM	IC50	Bioorg Med Chem Lett (2016) 26: 721-725 [PMID:26776360]
ChEMBL	Inhibition of KDM6B (unknown origin)	B	7.2	pIC50	63.1	nM	IC50	Medchemcomm (2014) 5: 1879-1886 [PMID:26682034]
GtoPdb	-	-	7.55	pIC50	28	nM	IC50	Nature (2012) 488: 404-8 [PMID:22842901]; Nature (2014) 514: E1-2 [PMID:25279926]
ChEMBL	Inhibition of C-terminal FLAG-tagged human KDM6B expressed in expressed in Sf9 cells pre-incubated for 4 hrs before substrate addition and measured after 1 hr by AlphaScreen assay	B	7.8	pIC50	16	nM	IC50	Bioorg Med Chem Lett (2019) 29: 1173-1176 [PMID:30928196]
Prolyl 4-hydroxylase in Paramecium bursaria Chlorella virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523368] [UniProtKB: Q84406]
ChEMBL	Inhibition of N-terminal His6-tagged recombinant Paramecium bursaria chlorella virus 1 CPH expressed in Escherichia coli Rosetta 2 (DE3) cells pre-incubated for 5 mins before 2OG as substrate and Fe2 as co-factor addition in presence of L-ascorbate and measured after 5 mins MALDI TOF MS analysis	B	4.8	pIC50	15900	nM	IC50	Bioorg Med Chem (2019) 27: 2405-2412 [PMID:30737136]
lysine demethylase 5B in Human [GtoPdb: 2681] [UniProtKB: Q9UGL1]
GtoPdb	-	-	6.77	pIC50	170	nM	IC50	Nature (2014) 514: E1-2 [PMID:25279926]
lysine demethylase 5C in Human [GtoPdb: 2682] [UniProtKB: P41229]
GtoPdb	-	-	6.26	pIC50	550	nM	IC50	Nature (2014) 514: E1-2 [PMID:25279926]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]