Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	1060	Xp11.22	PHF8	PHD finger protein 8
Mouse	-	1023	X F3	Phf8	PHD finger protein 8
Rat	-	1023	Xq21	Phf8	PHD finger protein 8

Previous and Unofficial Names

JHDM1F | KDM7B

Database Links
Alphafold	Q9UPP1 (Hs), Q80TJ7 (Mm)
BRENDA	1.14.11.27
CATH/Gene3D	3.30.40.10
ChEMBL Target	CHEMBL1938212 (Hs)
Ensembl Gene	ENSG00000172943 (Hs), ENSMUSG00000041229 (Mm), ENSRNOG00000002708 (Rn)
Entrez Gene	23133 (Hs), 320595 (Mm), 317425 (Rn)
Human Protein Atlas	ENSG00000172943 (Hs)
KEGG Enzyme	1.14.11.27
KEGG Gene	hsa:23133 (Hs), mmu:320595 (Mm), rno:317425 (Rn)
OMIM	300560 (Hs)
Pharos	Q9UPP1 (Hs)
RefSeq Nucleotide	NM_001184896 (Hs), NM_177201 (Mm), NM_001108253 (Rn)
RefSeq Protein	NP_001171825 (Hs), NP_796175 (Mm), NP_001101723 (Rn)
SynPHARM	79346 (in complex with daminozide)
UniProtKB	Q9UPP1 (Hs), Q80TJ7 (Mm)
Wikipedia	PHF8 (Hs)

Selected 3D Structures
	Description:  Crystal Structure of human PHF8 in complex with Daminozide PDB Id:  4DO0 Ligand:  daminozide Resolution:  2.55Å Species:  Human References:

Enzyme Reaction
EC Number: 1.14.11.27

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference daminozide Hs Inhibition 6.3 pIC50 1 ⤷ pIC50 6.3 (IC50 5.5x10-7 M) [1]

Clinically-Relevant Mutations and Pathophysiology
Disease:  Mental retardation syndrome, X-linked, Siderius type Synonyms: X-linked intellectual disability, Siderius type [Orphanet: ORPHA85287] OMIM: 300263 Orphanet: ORPHA85287