teneligliptin   Click here for help

GtoPdb Ligand ID: 9906

Synonyms: compound 8g [PMID: 22959556] | MP-513 | MP513 | Teneli
Approved drug PDB Ligand Immunopharmacology Ligand
teneligliptin is an approved drug (Japan (2012), S Korea (2014))
Compound class: Synthetic organic
Comment: Teneligliptin is a long-acting, orally bioavailable dipeptidyl peptidase 4 (DPP-4) inhibitor [3]. It was developed for clinical potential in type 2 diabetes management, to improve glycemic control. In addition to their anti-diabetic activity, DPP4 inhibitors may have renal and cardiovascular protective effects.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 81.42
Molecular weight 426.22
XLogP 2.43
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES O=C(N1CSCC1)C1NCC(C1)N1CCN(CC1)c1cc(nn1c1ccccc1)C
Isomeric SMILES O=C(N1CSCC1)[C@H]1NC[C@H](C1)N1CCN(CC1)c1cc(nn1c1ccccc1)C
InChI InChI=1S/C22H30N6OS/c1-17-13-21(28(24-17)18-5-3-2-4-6-18)26-9-7-25(8-10-26)19-14-20(23-15-19)22(29)27-11-12-30-16-27/h2-6,13,19-20,23H,7-12,14-16H2,1H3/t19-,20-/m0/s1
InChI Key WGRQANOPCQRCME-PMACEKPBSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (Japan (2012), S Korea (2014))
IUPAC Name Click here for help
[(2S,4S)-4-[4-(5-methyl-2-phenylpyrazol-3-yl)piperazin-1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone
International Nonproprietary Names Click here for help
INN number INN
8994 teneligliptin
Synonyms Click here for help
compound 8g [PMID: 22959556] | MP-513 | MP513 | Teneli
Database Links Click here for help
BindingDB Ligand 50391565
CAS Registry No. 760937-92-6 (source: WHO INN record)
ChEMBL Ligand CHEMBL2147777
DrugBank Ligand DB11950
DrugCentral Ligand 4895
GtoPdb PubChem SID 363894200
PubChem CID 11949652
RCSB PDB Ligand M51
Search Google for chemical match using the InChIKey WGRQANOPCQRCME-PMACEKPBSA-N
Search Google for chemicals with the same backbone WGRQANOPCQRCME
Search PubMed clinical trials teneligliptin
Search PubMed titles teneligliptin
Search PubMed titles/abstracts teneligliptin
SynPHARM 85060 (in complex with dipeptidyl peptidase 4)
UniChem Compound Search for chemical match using the InChIKey WGRQANOPCQRCME-PMACEKPBSA-N
UniChem Connectivity Search for chemical match using the InChIKey WGRQANOPCQRCME-PMACEKPBSA-N