teneligliptin [Ligand Id: 9906] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2147777 (MP-513, Teneligliptin, Teneligliptina, Teneligliptine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487] | ||||||||
| ChEMBL | Binding affinity to human recombinant DPP4 (39 to 766 residues) at 5 uM by isothermal titration calorimetry | B | 7.92 | pKd | 11.9 | nM | Kd | J Med Chem (2016) 59: 7466-7477 [PMID:27438064] |
| ChEMBL | Binding affinity to human recombinant DPP4 (39 to 766 residues) by surface plasmon resonance analysis | B | 9.39 | pKd | 0.41 | nM | Kd | J Med Chem (2016) 59: 7466-7477 [PMID:27438064] |
| GtoPdb | - | - | 9.43 | pIC50 | 0.37 | nM | IC50 | Bioorg Med Chem (2012) 20: 5705-19 [PMID:22959556] |
| ChEMBL | Inhibition of DPP4 in human plasma using GLY-Pro-MCA as substrate after 60 mins by fluorescence assay | B | 9.43 | pIC50 | 0.37 | nM | IC50 | Bioorg Med Chem (2012) 20: 5705-5719 [PMID:22959556] |
| dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4653] [GtoPdb: 1612] [UniProtKB: P14740] | ||||||||
| ChEMBL | Inhibition of DPP4 in rat plasma using GLY-Pro-MCA as substrate after 60 mins by fluorescence assay | B | 9.54 | pIC50 | 0.29 | nM | IC50 | Bioorg Med Chem (2012) 20: 5705-5719 [PMID:22959556] |
| dipeptidyl peptidase 9/Dipeptidyl peptidase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4793] [GtoPdb: 2357] [UniProtKB: Q86TI2] | ||||||||
| ChEMBL | Inhibition of human DPP9 using GLY-Pro-MCA as substrate after 30 mins by cell-based fluorescence assay | B | 6.27 | pIC50 | 540 | nM | IC50 | Bioorg Med Chem (2012) 20: 5705-5719 [PMID:22959556] |
| GtoPdb | - | - | 6.27 | pIC50 | 540 | nM | IC50 | Bioorg Med Chem (2012) 20: 5705-19 [PMID:22959556] |
| dipeptidyl peptidase 8/Dipeptidyl peptidase VIII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4657] [GtoPdb: 2356] [UniProtKB: Q6V1X1] | ||||||||
| ChEMBL | Inhibition of human DPP8 using GLY-Pro-MCA as substrate after 30 mins by cell-based fluorescence assay | B | 6.59 | pIC50 | 260 | nM | IC50 | Bioorg Med Chem (2012) 20: 5705-5719 [PMID:22959556] |
| GtoPdb | - | - | 6.59 | pIC50 | 260 | nM | IC50 | Bioorg Med Chem (2012) 20: 5705-19 [PMID:22959556] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
