teneligliptin [Ligand Id: 9906] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2147777 (MP-513, Teneligliptin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487] | ||||||||
| ChEMBL | Binding affinity to human recombinant DPP4 (39 to 766 residues) at 5 uM by isothermal titration calorimetry | B | 7.92 | pKd | 11.9 | nM | Kd | J Med Chem (2016) 59: 7466-7477 [PMID:27438064] |
| ChEMBL | Binding affinity to human recombinant DPP4 (39 to 766 residues) by surface plasmon resonance analysis | B | 9.39 | pKd | 0.41 | nM | Kd | J Med Chem (2016) 59: 7466-7477 [PMID:27438064] |
| GtoPdb | - | - | 9.43 | pIC50 | 0.37 | nM | IC50 | Bioorg Med Chem (2012) 20: 5705-19 [PMID:22959556] |
| ChEMBL | Inhibition of DPP4 in human plasma using GLY-Pro-MCA as substrate after 60 mins by fluorescence assay | B | 9.43 | pIC50 | 0.37 | nM | IC50 | Bioorg Med Chem (2012) 20: 5705-5719 [PMID:22959556] |
| dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4653] [GtoPdb: 1612] [UniProtKB: P14740] | ||||||||
| ChEMBL | Inhibition of DPP4 in rat plasma using GLY-Pro-MCA as substrate after 60 mins by fluorescence assay | B | 9.54 | pIC50 | 0.29 | nM | IC50 | Bioorg Med Chem (2012) 20: 5705-5719 [PMID:22959556] |
| dipeptidyl peptidase 9/Dipeptidyl peptidase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4793] [GtoPdb: 2357] [UniProtKB: Q86TI2] | ||||||||
| ChEMBL | Inhibition of human DPP9 using GLY-Pro-MCA as substrate after 30 mins by cell-based fluorescence assay | B | 6.27 | pIC50 | 540 | nM | IC50 | Bioorg Med Chem (2012) 20: 5705-5719 [PMID:22959556] |
| GtoPdb | - | - | 6.27 | pIC50 | 540 | nM | IC50 | Bioorg Med Chem (2012) 20: 5705-19 [PMID:22959556] |
| dipeptidyl peptidase 8/Dipeptidyl peptidase VIII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4657] [GtoPdb: 2356] [UniProtKB: Q6V1X1] | ||||||||
| ChEMBL | Inhibition of human DPP8 using GLY-Pro-MCA as substrate after 30 mins by cell-based fluorescence assay | B | 6.59 | pIC50 | 260 | nM | IC50 | Bioorg Med Chem (2012) 20: 5705-5719 [PMID:22959556] |
| GtoPdb | - | - | 6.59 | pIC50 | 260 | nM | IC50 | Bioorg Med Chem (2012) 20: 5705-19 [PMID:22959556] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
