Synonyms: Fagarasterol | Lupeol
Compound class:
Synthetic organic
Comment: Oral administration of Lupeol to dextran sulfate sodium (DSS)-induced colitis mice reduced intestinal inflammation and increased survival. This was associated with decreased expression of M1-related genes and increased expression of M2-related genes. Lupeol ameliorates experimental inflammatory bowel disease, at least in part, through inhibiting M1 and promoting M2 macrophages [2]. Similar results were simultaneously published in a different journal [1]. Note there are many isomers of this structure that can be found using the "same connectivity" operator in the PubChem CID entry.
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
(5aR,7aR,13bR)-3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysen-9-ol |
Synonyms ![]() |
Fagarasterol | Lupeol |
Database Links ![]() |
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GtoPdb PubChem SID | 315661113 |
PubChem CID | 16219576 |
Search Google for chemical match using the InChIKey | MQYXUWHLBZFQQO-HQBMYVNCSA-N |
Search Google for chemicals with the same backbone | MQYXUWHLBZFQQO |
UniChem Compound Search for chemical match using the InChIKey | MQYXUWHLBZFQQO-HQBMYVNCSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | MQYXUWHLBZFQQO-HQBMYVNCSA-N |
Wikipedia | https://en.wikipedia.org/wiki/Lupeol |