[14C]ascorbic acid [Ligand Id: 4532] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL196 (3-keto-l-gulofuranolactone, Acide ascorbique, Acido ascorbico, Acidum ascorbicum, Ascoltin, Ascor, Ascorbate, Ascorbic acid, Ascorbic Acid, Ascorbic acid, l-, Ascorbic acid (vit c), Ascorbicum acidum, Ascur, Bassett's, Cecon, Cenolate, Cevitamic acid, E-300, E300, FEMA NO. 2109, Haliborange, INS-300, INS NO.300, L-ascorbate, L-ascorbic acid, NSC-218455, NSC-33832, Redoxon, Redoxon c, Redoxon chew-c, Redoxon slow release, Top c, Vital life, Vitamin c, Vitamin C, Vitamin c (as ascorbic acid)) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089] | ||||||||
| ChEMBL | Agonist activity at human adrenergic alpha2B receptor expressed in HEK293 cells coexpressing Gqi5 protein by FLIPR assay | F | 9.3 | pEC50 | 0.5 | nM | EC50 | Bioorg Med Chem (2009) 17: 2497-2500 [PMID:19243956] |
| amylase alpha 2A/Pancreatic alpha-amylase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2699] [GtoPdb: 2596] [UniProtKB: P00689] | ||||||||
| ChEMBL | Inhibitory constant against Alpha-amylase | B | 4.36 | pKi | 43400 | nM | Ki | Bioorg Med Chem Lett (2000) 10: 1575-1576 [PMID:10915054] |
| ChEMBL | The compound was tested for inhibition of malt Alpha-amylase by Megazyme assay | B | 4.58 | pIC50 | 26500 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 1575-1576 [PMID:10915054] |
| tyrosinase/Tyrosinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1973] [GtoPdb: 2643] [UniProtKB: P14679] | ||||||||
| ChEMBL | Inhibition of tyrosinase (unknown origin) | B | 4.49 | pIC50 | 32500 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 1476-1478 [PMID:25726329] |
| Urease in Canavalia ensiformis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4161] [UniProtKB: P07374] | ||||||||
| ChEMBL | Inhibition of jack bean urease | B | 5.07 | pIC50 | 8590 | nM | IC50 | Eur J Med Chem (2022) 234: 114273-114273 [PMID:35305460] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
