[14C]ascorbic acid [Ligand Id: 4532] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL196 (3-keto-l-gulofuranolactone, Acidum ascorbicum, Ascoltin, Ascor, Ascorbate, Ascorbic acid, Ascorbic Acid, Ascorbic acid, l-, Ascorbic acid (vit c), Ascorbicap, Ascorbicum acidum, Ascur, Bassett's, Cebione, Cecon, Cenolate, Cetane, Cetane-caps tc, Cevalin, Cevex, Cevitamic acid, E300, E-300, FEMA NO. 2109, Haliborange, INS-300, INS NO.300, L-ascorbate, L-ascorbic acid, NSC-218455, NSC-33832, Redoxon, Redoxon c, Redoxon chew-c, Redoxon slow release, Top c, Vital life, Vitamin c, Vitamin C, Vitamin c (as ascorbic acid))
  • α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
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  • amylase alpha 2A/Pancreatic alpha-amylase in Rat [ChEMBL: CHEMBL2699] [GtoPdb: 2596] [UniProtKB: P00689]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
ChEMBL Agonist activity at human adrenergic alpha2B receptor expressed in HEK293 cells coexpressing Gqi5 protein by FLIPR assay F 9.3 pEC50 0.5 nM EC50 Bioorg. Med. Chem. (2009) 17: 2497-2500 [PMID:19243956]
amylase alpha 2A/Pancreatic alpha-amylase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2699] [GtoPdb: 2596] [UniProtKB: P00689]
ChEMBL Inhibitory constant against Alpha-amylase B 4.36 pKi 43400 nM Ki Bioorg. Med. Chem. Lett. (2000) 10: 1575-1576 [PMID:10915054]
ChEMBL The compound was tested for inhibition of malt Alpha-amylase by Megazyme assay B 4.58 pIC50 26500 nM IC50 Bioorg. Med. Chem. Lett. (2000) 10: 1575-1576 [PMID:10915054]
tyrosinase/Tyrosinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1973] [GtoPdb: 2643] [UniProtKB: P14679]
ChEMBL Inhibition of tyrosinase (unknown origin) B 4.49 pIC50 32500 nM IC50 Bioorg. Med. Chem. Lett. (2015) 25: 1476-1478 [PMID:25726329]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]