[14C]ascorbic acid [Ligand Id: 4532] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL196 (INS-300, Cecon, Redoxon, Vitamin C, Cenolate, Redoxon chew-c, FEMA NO. 2109, Top c, Bassett's, Haliborange, Redoxon slow release, Cetane, Ascur, Vital life, Ascorbic Acid, Ascor, E-300, Cevex, Ascorbic acid (vit c), Cevitamic acid, NSC-218455, Cevalin, Cetane-caps tc, Vitamin c, NSC-33832, Ascorbic acid, E300, Ascorbicap, INS NO.300, Redoxon c, Cebione)
  • α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
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  • amylase alpha 2A/Pancreatic alpha-amylase in Rat [ChEMBL: CHEMBL2699] [GtoPdb: 2596] [UniProtKB: P00689]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
ChEMBL Agonist activity at human adrenergic alpha2B receptor expressed in HEK293 cells coexpressing Gqi5 protein by FLIPR assay F 9.3 pEC50 0.5 nM EC50 Bioorg. Med. Chem. (2009) 17: 2497-2500 [PMID:19243956]
amylase alpha 2A/Pancreatic alpha-amylase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2699] [GtoPdb: 2596] [UniProtKB: P00689]
ChEMBL Inhibitory constant against Alpha-amylase B 4.36 pKi 43400 nM Ki Bioorg. Med. Chem. Lett. (2000) 10: 1575-1576 [PMID:10915054]
ChEMBL The compound was tested for inhibition of malt Alpha-amylase by Megazyme assay B 4.58 pIC50 26500 nM IC50 Bioorg. Med. Chem. Lett. (2000) 10: 1575-1576 [PMID:10915054]
tyrosinase/Tyrosinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1973] [GtoPdb: 2643] [UniProtKB: P14679]
ChEMBL Inhibition of tyrosinase (unknown origin) B 4.49 pIC50 32500 nM IC50 Bioorg. Med. Chem. Lett. (2015) 25: 1476-1478 [PMID:25726329]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]