XE991 [Ligand Id: 2596] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL342375 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of ERG in human HEK293 cells incubated for 1 hr by thallium flux assay | B | 4.49 | pIC50 | >32000 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 126681-126681 [PMID:31668424] |
| Kv7.2/Voltage-gated potassium channel subunit Kv7.2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2476] [GtoPdb: 561] [UniProtKB: O43526] | ||||||||
| GtoPdb | - | - | 6.15 | pIC50 | 710 | nM | IC50 | Science (1998) 282: 1890-3 [PMID:9836639] |
| ChEMBL | Inhibition of Kv7.2 in human HEK293 cells incubated for 1 hr by thallium flux assay | B | 7.26 | pIC50 | 55 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 126681-126681 [PMID:31668424] |
| Kv7.1 in Human [GtoPdb: 560] [UniProtKB: P51787] | ||||||||
| GtoPdb | - | - | 6.1 | pKd | 780 | nM | Kd | Mol Pharmacol (2000) 57: 1218-23 [PMID:10825393] |
| Kv7.4 in Human [GtoPdb: 563] [UniProtKB: P56696] | ||||||||
| GtoPdb | - | - | 5.3 | pIC50 | 5500 | nM | IC50 | Am J Physiol, Cell Physiol (2001) 280: C859-66 [PMID:11245603] |
| Kv7.5 in Human [GtoPdb: 564] [UniProtKB: Q9NR82] | ||||||||
| GtoPdb | - | - | 4.2 | pIC50 | 65000 | nM | IC50 | J Biol Chem (2000) 275: 24089-95 [PMID:10816588] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
