cholesterol [Ligand Id: 2718] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL112570 (Cholesterin, Cholesterol, NSC-8798, Cholestrin)
  • Androgen receptor/Androgen Receptor in Rat [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207]
  • This target only has 0 pki data point
  • 0
1 CHEMBL112570_lig_chart_1 Androgen Receptor Rat
There should be some charts here, you may need to enable JavaScript!
  • CYP46A1/Cholesterol 24-hydroxylase in Human [ChEMBL: CHEMBL4523510] [GtoPdb: 1373] [UniProtKB: Q9Y6A2]
  • This target only has 0 pki data point
  • 0
2 CHEMBL112570_lig_chart_2 Cholesterol 24-hydroxylase Human
There should be some charts here, you may need to enable JavaScript!
  • RAR-related orphan receptor-γ/Nuclear receptor ROR-gamma in Human [ChEMBL: CHEMBL1741186] [GtoPdb: 600] [UniProtKB: P51449]
  • This target only has 0 pki data point
  • 0
3 CHEMBL112570_lig_chart_3 Nuclear receptor ROR-gamma Human
There should be some charts here, you may need to enable JavaScript!
  • ABCB1/P-glycoprotein 1 in Human [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
  • This target only has 0 pki data point
  • 0
4 CHEMBL112570_lig_chart_4 P-glycoprotein 1 Human
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Androgen receptor/Androgen Receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207]
ChEMBL Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881) B 4.37 pIC50 >42657.95 nM IC50 J. Med. Chem. (2005) 48: 5666-5674 [PMID:16134935]
CYP46A1/Cholesterol 24-hydroxylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523510] [GtoPdb: 1373] [UniProtKB: Q9Y6A2]
ChEMBL Binding affinity to full-length recombinant human CYP46A1 by spectral binding study B 6.17 pKd 670 nM Kd US-20170182047-A9. Post-Translational Regulation of Catalytic Activities of Cytochrome P450 46A1 and Uses Thereof (null)
RAR-related orphan receptor-γ/Nuclear receptor ROR-gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1741186] [GtoPdb: 600] [UniProtKB: P51449]
ChEMBL Agonist activity at 6xHis tagged human RORgammat LBD (262 to 507 residues) expressed in Escherichia coli BL21 (DE3) assessed as biotinylated SRC1-2 peptide coactivator recruitment by AlphaScreen assay B 7.7 pEC50 20 nM EC50 J Med Chem (2018) 61: 5794-5804 [PMID:29412659]
ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
ChEMBL TP_TRANSPORTER: increase in Daunorubicn intracellular accumulation (Daunorubicin: ? uM) in NIH-G185 cells F 5.09 pIC50 8200 nM IC50 Biochem. Biophys. Res. Commun. (2000) 276: 909-916 [PMID:11027568]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]