cefixime   Click here for help

GtoPdb Ligand ID: 10898

Synonyms: (E)-Cefixime | Cefspan® | CFIX | FK-027 | FR-17027 | Suprax®
Approved drug PDB Ligand
cefixime is an approved drug (FDA (1989))
Compound class: Synthetic organic
Comment: Cefixime is a broad-spectrum, third-generation, orally active cephalosporin antibacterial.
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 10
Hydrogen bond donors 4
Rotatable bonds 9
Topological polar surface area 238.05
Molecular weight 453.04
XLogP -2.53
No. Lipinski's rules broken 0
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Canonical SMILES Nc1nc(cs1)/C(=N/OCC(=O)O)/C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)O)C=C
Isomeric SMILES Nc1nc(cs1)/C(=N/OCC(=O)O)/C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)O)C=C
InChI InChI=1S/C16H15N5O7S2/c1-2-6-4-29-14-10(13(25)21(14)11(6)15(26)27)19-12(24)9(20-28-3-8(22)23)7-5-30-16(17)18-7/h2,5,10,14H,1,3-4H2,(H2,17,18)(H,19,24)(H,22,23)(H,26,27)/b20-9-/t10-,14-/m1/s1
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1989))
WHO Essential Medicine WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version.
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IUPAC Name Click here for help
(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(carboxymethoxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
International Nonproprietary Names Click here for help
INN number INN
5678 cefixime
Synonyms Click here for help
(E)-Cefixime | Cefspan® | CFIX | FK-027 | FR-17027 | Suprax®
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Cefixime
Other databases
BindingDB Ligand 84007
CAS Registry No. 79350-37-1 (source: WHO INN record)
ChEMBL Ligand CHEMBL1541
DrugBank Ligand DB00671
DrugCentral Ligand 537
GtoPdb PubChem SID 405560339
PubChem CID 5362065
RCSB PDB Ligand C04
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UniChem Compound Search for chemical match using the InChIKey OKBVVJOGVLARMR-QSWIMTSFSA-N
UniChem Connectivity Search for chemical match using the InChIKey OKBVVJOGVLARMR-QSWIMTSFSA-N