cefixime   Click here for help

GtoPdb Ligand ID: 10898

Synonyms: (E)-Cefixime | Cefspan® | CFIX | FK-027 | FR-17027 | Suprax®
Approved drug PDB Ligand
cefixime is an approved drug (FDA (1989))
Compound class: Synthetic organic
Comment: Cefixime is a broad-spectrum, third-generation, orally active cephalosporin antibacterial.
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 10
Hydrogen bond donors 4
Rotatable bonds 9
Topological polar surface area 238.05
Molecular weight 453.04
XLogP -2.53
No. Lipinski's rules broken 0
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Canonical SMILES Nc1nc(cs1)/C(=N/OCC(=O)O)/C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)O)C=C
Isomeric SMILES Nc1nc(cs1)/C(=N/OCC(=O)O)/C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)O)C=C
InChI InChI=1S/C16H15N5O7S2/c1-2-6-4-29-14-10(13(25)21(14)11(6)15(26)27)19-12(24)9(20-28-3-8(22)23)7-5-30-16(17)18-7/h2,5,10,14H,1,3-4H2,(H2,17,18)(H,19,24)(H,22,23)(H,26,27)/b20-9-/t10-,14-/m1/s1
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Summary of Clinical Use Click here for help
Cefixime is indicated for the treatment of acute infections when caused by susceptible microorganisms, such as otitis media, upper and lower respiratory tract infections, and urinary tract infections.
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