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ChEMBL ligand: CHEMBL47244 (Picrotoxinin) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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glycine receptor α2 subunit in Human [GtoPdb: 424] [UniProtKB: P23416] | ||||||||
GtoPdb | - | - | 6.4 | pIC50 | 410 | nM | IC50 | |
glycine receptor α2 subunit/Glycine receptor subunit alpha-2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2328] [GtoPdb: 424] [UniProtKB: P22771] | ||||||||
ChEMBL | Inhibition of rat alpha2 homomeric glycine receptor expressed in CHO cells assessed as inhibition of 300 uM glycine-elicited current by outside patch clamp technique | B | 5.62 | pIC50 | 2400 | nM | IC50 | J Biol Chem (2007) 282: 16016-16035 [PMID:17405877] |
5-HT3AB in Human [GtoPdb: 378] | ||||||||
GtoPdb | - | - | 4.2 | pIC50 | 63000 | nM | IC50 | Neuropharmacology (2011) 60: 488-95 [PMID:21059362] |
5-HT3A in Human [GtoPdb: 379] | ||||||||
GtoPdb | - | - | 4.96 | pIC50 | 11000 | nM | IC50 | Mol Pharmacol (2011) 80: 183-90 [PMID:21505038] |
glycine receptor α1 subunit in Human [GtoPdb: 423] [UniProtKB: P23415] | ||||||||
GtoPdb | - | - | 5.3 | pIC50 | 5100 | nM | IC50 | |
glycine receptor α3 subunit in Human [GtoPdb: 425] [UniProtKB: O75311] | ||||||||
GtoPdb | - | - | 6.4 | pIC50 | 430 | nM | IC50 | |
glycine receptor β subunit in Human [GtoPdb: 427] [UniProtKB: P48167] | ||||||||
GtoPdb | - | - | 4.6 | pIC50 | 27000 | nM | IC50 | |
GtoPdb | - | - | 5.1 | pIC50 | 8900 | nM | IC50 | |
Glycine Receptor (All subtypes) in Human [GtoPdb: 428] | ||||||||
GtoPdb | - | - | 5.3 | pIC50 | - | - | - |
EMBO J (1992) 11: 4305-11 [PMID:1385113]; J Biol Chem (1995) 270: 13799-806 [PMID:7775436]; J Neurochem (2007) 103: 580-9 [PMID:17714449] |
TAS2R14 in Human [GtoPdb: 668] [UniProtKB: Q9NYV8] | ||||||||
GtoPdb | - | - | 4.74 | pEC50 | 18000 | nM | EC50 | Biochem Biophys Res Commun (2004) 319: 479-85 [PMID:15178431] |
TAS2R46 in Human [GtoPdb: 679] [UniProtKB: P59540] | ||||||||
GtoPdb | - | - | 4.15 | pEC50 | 70000 | nM | EC50 | J Agric Food Chem (2007) 55: 6236-43 [PMID:17595105] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]