duloxetine [Ligand Id: 202] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1175 (Cymbalta, Duloxetine, LY-248686, LY248686) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| DAT/Dopamine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959] | ||||||||
| ChEMBL | Displacement of [3H]WIN35428 from human DAT transfected in HEK293 cells after 3 hrs by Wallac counting analysis | B | 6.32 | pKi | 484 | nM | Ki | ACS Med Chem Lett (2013) 4: 560-564 [PMID:24900709] |
| ChEMBL | Displacement of [3H]dopamine from human DAT expressed in HEK293 cells by scintillation proximity assay | B | 6.36 | pKi | 435 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 3788-3792 [PMID:20471260] |
| ChEMBL | Inhibition of [3H]dopamine reuptake at human DAT expressed in HEK293 cells | B | 6.36 | pKi | 435 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2562-2566 [PMID:18387300] |
| ChEMBL | Displacement of [3H]dopamine from human DAT receptor expressed in HEK293 cells by scintillation counting | B | 6.36 | pKi | 435 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 5078-5081 [PMID:19647430] |
| ChEMBL | Inhibition constant against dopamine transporter | B | 6.43 | pKi | 370 | nM | Ki | J Med Chem (2005) 48: 6523-6543 [PMID:16220969] |
| ChEMBL | Displacement of [3H]WIN35428 from human recombinant DAT transfected in HEK293 cell membrane | B | 6.5 | pKi | 316.23 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 1456-1461 [PMID:23347683] |
| ChEMBL | Inhibition of DAT | B | 6.6 | pKi | 251.19 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 4630-4633 [PMID:19592243] |
| ChEMBL | Ability to inhibit the reuptake of dopamine at human dopamine transporter | B | 6.62 | pKi | 240 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 4477-4480 [PMID:14643350] |
| ChEMBL | Ability to inhibit [3H]WIN-35428 binding to cloned human dopamine (DA) transporter | B | 6.62 | pKi | 240 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 3481-3486 [PMID:15177457] |
| ChEMBL | Displacement of [3H]WIN-35428 form human DAT expressed in CHO cell membranes | B | 6 | pIC50 | >1000 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 2809-2812 [PMID:20378347] |
| ChEMBL | Inhibition of human DAT expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assay | B | 6.01 | pIC50 | 977 | nM | IC50 | ACS Med Chem Lett (2014) 5: 999-1004 [PMID:25221656] |
| ChEMBL | Inhibition of DA reuptake at human DAT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay | B | 6.01 | pIC50 | 977 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 3234-3237 [PMID:24974340] |
| ChEMBL | Inhibition of [3H]DA reuptake at DA transporter in HEK293 cells | B | 6.06 | pIC50 | 870 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 4349-4353 [PMID:16750363] |
| ChEMBL | Inhibition of DA transporter expressed in HEK293 cells | B | 6.06 | pIC50 | 870 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 4345-4348 [PMID:16750359] |
| ChEMBL | Inhibition of [3H]DA from human DAT expressed in HEK293 cells | B | 6.06 | pIC50 | 870 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 2022-2025 [PMID:17267217] |
| ChEMBL | Displacement of 3,4-[ring-2,5,6-3H]dihydroxyphenylethylamine from human cloned DAT expressed in HEK293 cells by microplate scintillation counter | B | 6.18 | pIC50 | 660 | nM | IC50 | J Med Chem (2008) 51: 7265-7272 [PMID:18954038] |
| ChEMBL | Inhibition of human DAT | B | 6.18 | pIC50 | 660 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 1346-1349 [PMID:18207394] |
| ChEMBL | Inhibition of [3H]DA uptake at human DAT expressed in HEK293 cells | B | 6.23 | pIC50 | 590 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2829-2834 [PMID:19359175] |
| DAT/Dopamine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL338] [GtoPdb: 927] [UniProtKB: P23977] | ||||||||
| ChEMBL | Displacement of [125I]RTI55 from DAT in Sprague-dawley rat striatum by liquid scintillation spectrophotometry | B | 6.43 | pIC50 | 370 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 58-61 [PMID:19038547] |
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using IonWorks Quattro automated patch clamp platform | F | 5 | pIC50 | 10000 | nM | IC50 | J Pharmacol Toxicol Methods (2014) 70: 246-254 [PMID:25087753] |
| ChEMBL | Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) cells stable expressing hERG measured using IonWorks Barracuda automated patch clamp platform | F | 5.2 | pIC50 | 6309.57 | nM | IC50 | J Pharmacol Toxicol Methods (2014) 70: 246-254 [PMID:25087753] |
| ChEMBL | Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay | F | 5.3 | pIC50 | 5011.87 | nM | IC50 | J Pharmacol Toxicol Methods (2014) 70: 246-254 [PMID:25087753] |
| H3 receptor/Histamine H3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL264] [GtoPdb: 264] [UniProtKB: Q9Y5N1] | ||||||||
| ChEMBL | Displacement of [3H]N-R-methylhistamine from human H3 receptor isolated from C6 cells | B | 5.3 | pKi | >5000 | nM | Ki | J Med Chem (2010) 53: 7869-7873 [PMID:20945906] |
| H3 receptor/Histamine H3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4124] [GtoPdb: 264] [UniProtKB: Q9QYN8] | ||||||||
| ChEMBL | Displacement of [3H]N-R-methylhistamine from rat H3 receptor | B | 5.3 | pKi | >5000 | nM | Ki | J Med Chem (2010) 53: 7869-7873 [PMID:20945906] |
| NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975] | ||||||||
| ChEMBL | Displacement of [3H]noradrenaline from human NET receptor expressed in HEK293 cells by scintillation counting | B | 7.35 | pKi | 45 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 5078-5081 [PMID:19647430] |
| ChEMBL | Displacement of [3H]nisoxetine from human NET expressed in HEK293 cells by scintillation proximity assay | B | 7.35 | pKi | 45 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 3788-3792 [PMID:20471260] |
| ChEMBL | Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells | B | 7.35 | pKi | 45 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2562-2566 [PMID:18387300] |
| ChEMBL | Inhibition constant against norepinephrine transporter | B | 7.8 | pKi | 16 | nM | Ki | J Med Chem (2005) 48: 6523-6543 [PMID:16220969] |
| ChEMBL | Inhibition of NET | B | 8.1 | pKi | 7.94 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 4630-4633 [PMID:19592243] |
| ChEMBL | Ability to inhibit the reuptake of NE at human norepinephrine transporter | B | 8.12 | pKi | 7.5 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 4477-4480 [PMID:14643350] |
| ChEMBL | Ability to inhibit [3H]nisoxetine binding to cloned human norepinephrine (NE) transporter | B | 8.13 | pKi | 7.45 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 3481-3486 [PMID:15177457] |
| ChEMBL | Displacement of [3H]Nisoxetine from human NET transfected in HEK293 cells after 3 hrs by Wallac counting analysis | B | 8.17 | pKi | 6.7 | nM | Ki | ACS Med Chem Lett (2013) 4: 560-564 [PMID:24900709] |
| GtoPdb | - | - | 8.22 | pKi | 5.97 | nM | Ki | Bioorg Med Chem Lett (2012) 22: 7219-22 [PMID:23084899] |
| ChEMBL | Inhibition of human NET | B | 8.22 | pKi | 5.97 | nM | Ki | Bioorg Med Chem Lett (2012) 22: 7219-7222 [PMID:23084899] |
| ChEMBL | Inhibition of human NET expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assay | B | 6.29 | pIC50 | 515 | nM | IC50 | ACS Med Chem Lett (2014) 5: 999-1004 [PMID:25221656] |
| ChEMBL | Inhibition of norepinephrine reuptake at human NET expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay | B | 6.29 | pIC50 | 515 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 3234-3237 [PMID:24974340] |
| ChEMBL | Displacement of [3H]Nisoxetine from human NET transfected in HEK293 cells after 3 hrs by Wallac counting analysis | B | 7.54 | pIC50 | 29 | nM | IC50 | ACS Med Chem Lett (2013) 4: 560-564 [PMID:24900709] |
| ChEMBL | Inhibition of [3H]NA reuptake at NA transporter in HEK293 cells | B | 7.72 | pIC50 | 19 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 4349-4353 [PMID:16750363] |
| ChEMBL | Inhibition of [3H]NA uptake at NA transporter expressed in HEK293 cells | B | 7.72 | pIC50 | 19 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 4345-4348 [PMID:16750359] |
| ChEMBL | Inhibition of [3H]NA from human NET expressed in HEK293 cells | B | 7.72 | pIC50 | 19 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 2022-2025 [PMID:17267217] |
| ChEMBL | Inhibition of human NET | B | 8.05 | pIC50 | 8.9 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 1346-1349 [PMID:18207394] |
| ChEMBL | Displacement of Levo[ring-2,5,6-3H]norepinephrine from human cloned NET expressed in HEK293 cells by microplate scintillation counter | B | 8.05 | pIC50 | 8.9 | nM | IC50 | J Med Chem (2008) 51: 7265-7272 [PMID:18954038] |
| ChEMBL | Inhibition of [3H]NA uptake at human NET expressed in HEK293 cells | B | 8.3 | pIC50 | 5 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2829-2834 [PMID:19359175] |
| ChEMBL | Inhibition of human NET transfected in MDCK-Net6 cells | B | 8.4 | pIC50 | 4 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 2809-2812 [PMID:20378347] |
| ChEMBL | Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cells | B | 8.4 | pIC50 | 4 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2464-2467 [PMID:19329313] |
| ChEMBL | Inhibition of norepinephrine uptake at human NET expressed in MDCK cells | B | 8.4 | pIC50 | 4 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4929-4931 [PMID:18771916] |
| ChEMBL | Inhibition of human recombinant NET expressed in HEK293 cells assessed as inhibition of [3H]NE reuptake | B | 8.8 | pIC50 | 1.58 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1456-1461 [PMID:23347683] |
| Serine hydroxymethyltransferase, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295747] [UniProtKB: P34897] | ||||||||
| ChEMBL | Inhibition of His-tagged human recombinant SHMT2 expressed in Escherichia coli BLR(DE3) assessed as reduction in NADPH level using L-serine, THF and NADP+ incubated for 5 mins by SHMT2-MTHFD coupled reaction based fluorescence assay | B | 5.16 | pIC50 | 6918.31 | nM | IC50 | WO-2016085990-A1. Compositions and methods relating to inhibiting serine hyrdoxymethyltransferase 2 activity (null) |
| SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645] | ||||||||
| GtoPdb | - | - | 8.3 | pKi | 5 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2562-6 [PMID:18387300] |
| ChEMBL | Displacement of [3H]citalopram from human SERT expressed in HEK293 cells by scintillation proximity assay | B | 8.3 | pKi | 5 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 3788-3792 [PMID:20471260] |
| ChEMBL | Inhibition of [3H]citalopram uptake at human 5HTT expressed in HEK293 cells | B | 8.3 | pKi | 5 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2562-2566 [PMID:18387300] |
| ChEMBL | Displacement of [3H]5HT from human 5HT transporter expressed in HEK293 cells by scintillation counting | B | 8.3 | pKi | 5 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 5078-5081 [PMID:19647430] |
| ChEMBL | Inhibition constant against serotonin transporter | B | 8.34 | pKi | 4.6 | nM | Ki | J Med Chem (2005) 48: 6523-6543 [PMID:16220969] |
| ChEMBL | Ability to inhibit the reuptake of 5-HT at human serotonin transporter | B | 9.1 | pKi | 0.8 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 4477-4480 [PMID:14643350] |
| ChEMBL | Ability to inhibit [3H]paroxetine binding to cloned human serotonin (5-HT) transporter | B | 9.1 | pKi | 0.79 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 3481-3486 [PMID:15177457] |
| ChEMBL | Inhibition of SERT | B | 9.3 | pKi | 0.5 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 4630-4633 [PMID:19592243] |
| ChEMBL | Displacement of [3H]citalopram from human SERT transfected in HEK293 cells after 3 hrs by Wallac counting analysis | B | 9.62 | pKi | 0.24 | nM | Ki | ACS Med Chem Lett (2013) 4: 560-564 [PMID:24900709] |
| ChEMBL | Inhibition of human SERT expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assay | B | 7.98 | pIC50 | 10.4 | nM | IC50 | ACS Med Chem Lett (2014) 5: 999-1004 [PMID:25221656] |
| ChEMBL | Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay | B | 7.98 | pIC50 | 10.4 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 3234-3237 [PMID:24974340] |
| ChEMBL | Displacement of [alpha,beta-3H(N)]-5-hydroxytryptamine from human cloned SERT expressed in HEK293 cells by microplate scintillation counter | B | 8.18 | pIC50 | 6.6 | nM | IC50 | J Med Chem (2008) 51: 7265-7272 [PMID:18954038] |
| ChEMBL | Inhibition of human SERT | B | 8.18 | pIC50 | 6.6 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 1346-1349 [PMID:18207394] |
| ChEMBL | Inhibition of [3H]5-HT reuptake at 5HT transporter in HEK293 cells | B | 8.22 | pIC50 | 6 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 4349-4353 [PMID:16750363] |
| ChEMBL | Inhibition of [3H]5-HT uptake at 5HT transporter expressed in HEK293 cells | B | 8.22 | pIC50 | 6 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 4345-4348 [PMID:16750359] |
| ChEMBL | Inhibition of [3H]5-HT from human SERT expressed in HEK293 cells | B | 8.22 | pIC50 | 6 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 2022-2025 [PMID:17267217] |
| ChEMBL | Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cells | B | 8.4 | pIC50 | 4 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2829-2834 [PMID:19359175] |
| ChEMBL | Inhibition of human SERT expressed in human JAR cells | B | 8.52 | pIC50 | 3 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 2809-2812 [PMID:20378347] |
| ChEMBL | Inhibition of serotonin uptake at human SERT expressed in human JAR cells | B | 8.52 | pIC50 | 3 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2464-2467 [PMID:19329313] |
| ChEMBL | Inhibition of serotonin uptake at human SERT expressed in JAR cells | B | 8.52 | pIC50 | 3 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4929-4931 [PMID:18771916] |
| ChEMBL | Displacement of [3H]citalopram from human SERT transfected in HEK293 cells after 3 hrs by Wallac counting analysis | B | 8.64 | pIC50 | 2.3 | nM | IC50 | ACS Med Chem Lett (2013) 4: 560-564 [PMID:24900709] |
| ChEMBL | Inhibition of human recombinant SERT expressed in HEK293 cells assessed as inhibition of [3H]5HT reuptake | B | 9.5 | pIC50 | 0.32 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1456-1461 [PMID:23347683] |
| SERT/Serotonin transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652] | ||||||||
| ChEMBL | Displacement of [3H]citalopram from SERT in Sprague-dawley rat frontal cortex by liquid scintillation spectrophotometry | B | 8.34 | pKi | 4.6 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 58-61 [PMID:19038547] |
| ChEMBL | Displacement of [3H]-citalopram from Sprague-Dawley rat brain SERT after 1 hr | B | 10.09 | pKi | 0.08 | nM | Ki | ACS Med Chem Lett (2013) 4: 560-564 [PMID:24900709] |
| Nav1.5/Sodium channel protein type V alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1980] [GtoPdb: 582] [UniProtKB: Q14524] | ||||||||
| ChEMBL | Inhibition of fast sodium current (INa) in HEK293 cells transfected with human Nav1.5 measured using IonWorks Quattro automated patch clamp platform | F | 4.8 | pIC50 | 15848.93 | nM | IC50 | J Pharmacol Toxicol Methods (2014) 70: 246-254 [PMID:25087753] |
| ChEMBL | Inhibition of fast sodium current (INa) in Chinese Hamster Ovary (CHO) K1 cells transfected with human Nav1.5 measured using IonWorks Quattro automated patch clamp platform | F | 5.1 | pIC50 | 7943.28 | nM | IC50 | J Pharmacol Toxicol Methods (2014) 70: 246-254 [PMID:25087753] |
| Transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6184] [UniProtKB: Q63380] | ||||||||
| ChEMBL | Displacement of [3H]nisoxetine from Sprague-dawley rat NET by liquid scintillation spectrophotometry | B | 7.8 | pKi | 16 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 58-61 [PMID:19038547] |
| ChEMBL | Inhibition of rat NET | B | 8.41 | pKi | 3.9 | nM | Ki | Bioorg Med Chem Lett (2012) 22: 7219-7222 [PMID:23084899] |
| ChEMBL | Displacement of [3H]nisoxetine from rat NET in rat cerebral cortex | B | 8.52 | pKi | 3 | nM | Ki | J Med Chem (2010) 53: 7869-7873 [PMID:20945906] |
| Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1940] [GtoPdb: 529] [UniProtKB: Q13936] | ||||||||
| ChEMBL | Inhibition of long-lasting type calcium current (hICa) in Chinese Hamster Ovary (CHO) cells expressing hCav1.2 measured using IonWorks Quattro automated patch clamp platform | F | 4 | pIC50 | 100000 | nM | IC50 | J Pharmacol Toxicol Methods (2014) 70: 246-254 [PMID:25087753] |
| ChEMBL | Inhibition of long-lasting type calcium current (ICaL) in HEK293 cells (alpha1C/beta2a/alpha2delta1) cells measured using IonWorks Barracuda automated patch clamp platform | F | 4.6 | pIC50 | 25118.86 | nM | IC50 | J Pharmacol Toxicol Methods (2014) 70: 246-254 [PMID:25087753] |
| Kv7.1/Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2221347] [GtoPdb: 560] [UniProtKB: P15382, P51787] | ||||||||
| ChEMBL | Inhibition of slow delayed inward rectifying potassium current (Iks) in Chinese Hamster Ovary (CHO) cells expressing hKvLQT1/hminK measured using IonWorks Quattro automated patch clamp platform | F | 5 | pIC50 | 10000 | nM | IC50 | J Pharmacol Toxicol Methods (2014) 70: 246-254 [PMID:25087753] |
| Kv4.3/Voltage-gated potassium channel subunit Kv4.3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1964] [GtoPdb: 554] [UniProtKB: Q9UK17] | ||||||||
| ChEMBL | Inhibition of transient outward potassium current (Ito) current in Chinese Hamster Ovary (CHO) K1 cells expressing human Kv4.3 measured using IonWorks Quattro automated patch clamp platform | F | 4 | pIC50 | 100000 | nM | IC50 | J Pharmacol Toxicol Methods (2014) 70: 246-254 [PMID:25087753] |
| 5-HT2A receptor in Human [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
| GtoPdb | - | - | 6.3 | pKi | - | - | - | Neuropsychopharmacology (2001) 25: 871-80 [PMID:11750180] |
| 5-HT2C receptor in Human [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
| GtoPdb | - | - | 6 | pKi | - | - | - | Neuropsychopharmacology (2001) 25: 871-80 [PMID:11750180] |
| 5-HT6 receptor in Human [GtoPdb: 11] [UniProtKB: P50406] | ||||||||
| GtoPdb | - | - | 6.4 | pKi | - | - | - | Neuropsychopharmacology (2001) 25: 871-80 [PMID:11750180] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
