ChEMBL ligand: CHEMBL4303589
KCa1.1/Calcium-activated potassium channel subunit alpha-1 in Human [ChEMBL: CHEMBL4304] [GtoPdb: 380] [UniProtKB: Q12791] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
KCa1.1/Calcium-activated potassium channel subunit alpha-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4304] [GtoPdb: 380] [UniProtKB: Q12791]
GtoPdb	-	-	5	pEC50	10000	nM	EC50	Mol Pharmacol (2007) 72: 1033-44 [PMID:17636045]
ChEMBL	Activation of BKca channel (unknown origin) by cell-based fluorescence assay	B	5.15	pEC50	7000	nM	EC50	J Med Chem (2025) 68: 4259-4286 [PMID:39947888]
ChEMBL	Activation of BKca channel (unknown origin) by cell based method	B	5.15	pEC50	7000	nM	EC50	J Med Chem (2025) 68: 4259-4286 [PMID:39947888]
ChEMBL	Activation of human KCa1.1 by patch clamp method	B	6.4	pEC50	400	nM	EC50	J Med Chem (2025) 68: 4259-4286 [PMID:39947888]
GtoPdb	-	-	6.4	pEC50	400	nM	EC50	Mol Pharmacol (2007) 72: 1033-44 [PMID:17636045]

ChEMBL data shown on this page come from version 37:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]